期刊
APMIS
卷 116, 期 7-8, 页码 677-684出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1600-0463.2008.01026.x
关键词
breast cancer; dormancy; integrin; tumour environment; stem cells; niche
资金
- Terry Fox Foundation
- National Cancer Institute of Canada (NCIC)
- Canadian Institutes of Health Research (CIHR)
- Canadian Breast Cancer Research Alliance (CBCRA)
- US Department of Defense
- National Institutes of Health
Among breast cancer patients, 20% to 45% develop malignant lesions following their initial treatment. This relapse may occur after an apparent remission period that can range from years to several decades. Clinical observations suggest that breast-derived malignant cells have the ability to survive subclinically for a very long period of time before eventually resuming proliferation and forming detectable lesions. While the precise molecular events that correspond to this dormant phenotype remain poorly understood, data published during the last 10 years have underlined an important role of integrin proteins in the regulation of this phenomenon.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据