The Tumor Microenvironment: Characterization, Redox Considerations, and Novel Approaches for Reactive Oxygen Species-Targeted Gene Therapy

Recent Advances in Anti-Angiogenic Therapy of Cancer

(2015) Rajeev S. Samant et al.   Oncotarget

Ablation of Breast Cancer Stem Cells with Radiation

(2014) Steven P. Zielske et al.   Translational Oncology

Antioxidants for prostate cancer chemoprevention: Challenges and opportunities

(2012) Dinesh Thapa et al.   BIOCHEMICAL PHARMACOLOGY

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

(2012) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-Viral Nucleic Acid Delivery: Key Challenges and Future Directions

(2012) Mahmoud Elsabahy et al.   Current Drug Delivery

Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial–Mesenchymal Transition-like Phenomenon

(2011) Ho Min Kim et al.   ANNALS OF SURGICAL ONCOLOGY

Redox Control of the Survival of Healthy and Diseased Cells

(2011) Yuxing Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

(2011) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Regulation of Cell Cycle and Proliferation

(2011) Valeria Gabriela Antico Arciuch et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2

(2011) Shefali Krishna et al.   BIOCHEMICAL JOURNAL

Catalase overexpression in mammary cancer cells leads to a less aggressive phenotype and an altered response to chemotherapy

(2011) Christophe Glorieux et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial targeted catalase suppresses invasive breast cancer in mice

(2011) Jorming Goh et al.   BMC CANCER

Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas

(2011) Peeter Karihtala et al.   BMC CANCER

What does matrix metalloproteinase-1 expression in patients with breast cancer really tell us?

(2011) Ferdinando Mannello   BMC Medicine

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

(2011) Federica Sotgia et al.   BMC Medicine

Novel, chimeric, cancer-specific, and radiation-inducible gene promoters for suicide gene therapy of cancer

(2011) Jie Xiong et al.   CANCER

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment

(2011) Casey Trimmer et al.   CANCER BIOLOGY & THERAPY

EMT: A new vision of hypoxia promoting cancer progression

(2011) Jian Jiang et al.   CANCER BIOLOGY & THERAPY

H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1

(2011) Irene L. Ibañez et al.   CANCER LETTERS

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

(2011) A. D. Gregory et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cancer Stem Cells Switch on Tumor Neovascularization

(2011) Y.-F. Ping et al.   CURRENT MOLECULAR MEDICINE

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

(2011) Robin Mathew et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity

(2011) Caroline Jochems et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tumor exploits alternative strategies to achieve vascularization

(2011) Benedetta Bussolati et al.   FASEB JOURNAL

Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes

(2011) Xu Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Expression of microRNA 210 associates with poor survival and age of tumor onset of soft-tissue sarcoma patients

(2011) T. Greither et al.   INTERNATIONAL JOURNAL OF CANCER

Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells

(2011) Xiao-Qun Ye et al.   INTERNATIONAL JOURNAL OF CANCER

The cancer stem cell niche-there goes the neighborhood?

(2011) Stephanie M. Cabarcas et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxia and neural stem cells: from invertebrates to brain cancer stem cells

(2011) Ferdinando Mannello et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species

(2011) Santhi Achuthan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Underexpressed microRNA-199b-5p targets Hypoxia-Inducible Factor-1α in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients

(2011) Chuanxi Wang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Growing tumor vessels: More than one way to skin a cat – Implications for angiogenesis targeted cancer therapies

(2011) Rodrigo Leite de Oliveira et al.   MOLECULAR ASPECTS OF MEDICINE

ROS Signaling by NOX4 Drives Fibroblast-to-Myofibroblast Differentiation in the Diseased Prostatic Stroma

(2011) Natalie Sampson et al.   MOLECULAR ENDOCRINOLOGY

Imaging the Impact of Nox4 in Cycling Hypoxia-mediated U87 Glioblastoma Invasion and Infiltration

(2011) Chia-Hung Hsieh et al.   MOLECULAR IMAGING AND BIOLOGY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Cell death assays for drug discovery

(2011) Oliver Kepp et al.   NATURE REVIEWS DRUG DISCOVERY

A Pilot Feasibility Study of TNFerade™ Biologic with Capecitabine and Radiation Therapy Followed by Surgical Resection for the Treatment of Rectal Cancer

(2011) Deborah Citrin et al.   ONCOLOGY

Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

MicroRNA-22 Regulates Hypoxia Signaling in Colon Cancer Cells

(2011) Munekazu Yamakuchi et al.   PLoS One

Acidic Environment Leads to ROS-Induced MAPK Signaling in Cancer Cells

(2011) Anne Riemann et al.   PLoS One

Positron Emission Tomography Imaging of Cancer Biology: Current Status and Future Prospects

(2011) Kai Chen et al.   SEMINARS IN ONCOLOGY

Revisiting the TCA cycle: signaling to tumor formation

(2011) Nuno Raimundo et al.   TRENDS IN MOLECULAR MEDICINE

Effects of cyclooxygenase-2 on human esophageal squamous cell carcinoma

(2011) Li Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

An Insult-Inducible Vector System Activated by Hypoxia and Oxidative Stress for Neuronal Gene Therapy

(2011) Michelle Y. Cheng et al.   Translational Stroke Research

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Redox Control of Protein–DNA Interactions: From Molecular Mechanisms to Significance in Signal Transduction, Gene Expression, and DNA Replication

(2010) Joseph Shlomai   ANTIOXIDANTS & REDOX SIGNALING

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Interaction of p53 with Tumor Suppressive and Oncogenic Signaling Pathways to Control Cellular Reactive Oxygen Species Production

(2010) María Fátima Ladelfa et al.   ANTIOXIDANTS & REDOX SIGNALING

The Emerging Role of the Thioredoxin System in Angiogenesis

(2010) Louise L. Dunn et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction

(2010) Robyn L. Poerschke et al.   BIOCHEMICAL PHARMACOLOGY

Hypoxia and mitochondrial oxidative metabolism

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?

(2010) Caroline Jose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

High-mobility group box 1 and cancer

(2010) Daolin Tang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mechanisms associated with mitochondrial-generated reactive oxygen species in cancerThis article is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Meghan L. Verschoor et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Metastasis: cancer cell’s escape from oxidative stress

(2010) Giovambattista Pani et al.   CANCER AND METASTASIS REVIEWS

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

(2010) David G. DeNardo et al.   CANCER AND METASTASIS REVIEWS

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer

(2010) J Du et al.   CANCER GENE THERAPY

Retargeting adenoviral vectors to improve gene transfer into tumors

(2010) R T Hogg et al.   CANCER GENE THERAPY

Reduced Reactive Oxygen Species–Generating Capacity Contributes to the Enhanced Cell Growth of Arsenic-Transformed Epithelial Cells

(2010) Qingshan Chang et al.   CANCER RESEARCH

Imaging Cycling Tumor Hypoxia

(2010) S. Matsumoto et al.   CANCER RESEARCH

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

(2010) T. Jiang et al.   CANCER RESEARCH

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

The paradox of tumor-associated neutrophils: Fueling tumor growth with cytotoxic substances

(2010) A. McGarry Houghton   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

MicroRNA-128 downregulates Bax and induces apoptosis in human embryonic kidney cells

(2010) Yogita K. Adlakha et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Eosinophils in health and disease: the LIAR hypothesis

(2010) J. J. Lee et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Detection of Superoxide Dismutase-1 in Nipple Aspirate Fluids: A Reactive Oxygen Species—Regulating Enzyme in the Breast Cancer Microenvironment

(2010) Ferdinando Mannello et al.   Clinical Breast Cancer

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Tumour Reactions to Hypoxia

(2010) M.J. Voss et al.   CURRENT MOLECULAR MEDICINE

Hypoxia and energetic tumour metabolism

(2010) M Christiane Brahimi-Horn et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The dendritic cell–tumor cross-talk in cancer

(2010) Yuting Ma et al.   CURRENT OPINION IN IMMUNOLOGY

Redox metabolism and malignancy

(2010) Christina L Grek et al.   CURRENT OPINION IN PHARMACOLOGY

Characterization of Molecular and Functional Alterations of Tumor Endothelial Cells to Design Anti-Angiogenic Strategies

(2010) Benedetta Bussolati et al.   Current Vascular Pharmacology

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Downregulation of catalase by reactive oxygen species via hypermethylation of CpG island II on the catalase promoter

(2010) Ji Young Min et al.   FEBS LETTERS

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

(2010) Katarína Smolková et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of Peroxiredoxin I in Rectal Cancer and Related to p53 Status

(2010) Miao-Fen Chen et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Quantitative mitochondrial redox imaging of breast cancer metastatic potential

(2010) He N. Xu et al.   JOURNAL OF BIOMEDICAL OPTICS

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

pH control mechanisms of tumor survival and growth

(2010) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling

(2010) Ying Qu et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloperoxidase Expression as a Potential Determinant of Parthenolide-Induced Apoptosis in Leukemia Bulk and Leukemia Stem Cells

(2010) Y. R. Kim et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

(2010) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation

(2010) P Swietach et al.   ONCOGENE

Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential

(2010) Asha Acharya et al.   Oxidative Medicine and Cellular Longevity

MicroRNA 128a Increases Intracellular ROS Level by Targeting Bmi-1 and Inhibits Medulloblastoma Cancer Cell Growth by Promoting Senescence

(2010) Sujatha Venkataraman et al.   PLoS One

Point Mutations in c-Myc Uncouple Neoplastic Transformation from Multiple Other Phenotypes in Rat Fibroblasts

(2010) J. Anthony Graves et al.   PLoS One

miR-17* Suppresses Tumorigenicity of Prostate Cancer by Inhibiting Mitochondrial Antioxidant Enzymes

(2010) Yong Xu et al.   PLoS One

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Therapeutic strategies by modulating oxygen stress in cancer and inflammation

(2009) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Thioredoxins and Glutaredoxins: Unifying Elements in Redox Biology

(2009) Yves Meyer et al.   Annual Review of Genetics

MicroRNAs in Cancer

(2009) Ramiro Garzon et al.   Annual Review of Medicine

Redox Control of the Cell Cycle in Health and Disease

(2009) Ehab H. Sarsour et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel Role of NADPH Oxidase in Angiogenesis and Stem/Progenitor Cell Function

(2009) Masuko Ushio-Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox-Based Escape Mechanism from Death: The Cancer Lesson

(2009) Giovambattista Pani et al.   ANTIOXIDANTS & REDOX SIGNALING

Adaptation to Oxidative Stress, Chemoresistance, and Cell Survival

(2009) Matteo Landriscina et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox-4–Dependent Nuclear H2O2 Drives DNA Oxidation Resulting in 8-OHdG as Urinary Biomarker and Hemangioendothelioma Formation

(2009) Gayle Gordillo et al.   ANTIOXIDANTS & REDOX SIGNALING

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes

(2009) E. V. Kalinina et al.   BIOCHEMISTRY-MOSCOW

Selenoproteins that function in cancer prevention and promotion

(2009) Dolph L. Hatfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Catalytic mechanisms and specificities of glutathione peroxidases: Variations of a basic scheme

(2009) Stefano Toppo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

(2009) Elias S.J. Arnér   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The bioenergetics of cancer: Is glycolysis the main ATP supplier in all tumor cells?

(2009) Rafael Moreno-Sánchez et al.   BIOFACTORS

Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ hematopoietic progenitor cells

(2009) P. S. Hole et al.   BLOOD

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Peroxiredoxins, a novel target in cancer radiotherapy

(2009) Bo Zhang et al.   CANCER LETTERS

Overexpression of Extracellular Superoxide Dismutase Attenuates Heparanase Expression and Inhibits Breast Carcinoma Cell Growth and Invasion

(2009) M. L.T. Teoh et al.   CANCER RESEARCH

Roles of Nox1 and other Nox isoforms in cancer development

(2009) Tohru Kamata   CANCER SCIENCE

Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy

(2009) O. Zabirnyk et al.   CARCINOGENESIS

Reactive oxygen species-dependent signaling regulates cancer

(2009) Frank Weinberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Regulation of Tumor Angiogenesis and Perfusion via Redox Signaling

(2009) Thomas W. Miller et al.   CHEMICAL REVIEWS

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

(2009) Gregory B. Waypa et al.   CIRCULATION RESEARCH

Matricellular proteins and inflammatory cells: A task force to promote or defeat cancer?

(2009) Andrea Sabina Llera et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The chemokine system in cancer biology and therapy

(2009) Alberto Mantovani et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

(2009) S. A. Arnold et al.   Disease Models & Mechanisms

Angiogenesis in pre-malignant conditions

(2009) Marius Raica et al.   EUROPEAN JOURNAL OF CANCER

Viral-based gene delivery and regulated gene expression for targeted cancer therapy

(2009) Yi Lu et al.   Expert Opinion on Drug Delivery

Overexpression of catalase delays G0/G1- to S-phase transition during cell cycle progression in mouse aortic endothelial cells

(2009) Ogbeyalu E. Onumah et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation

(2009) Deobrat Dixit et al.   FREE RADICAL BIOLOGY AND MEDICINE

High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy

(2009) Sofi E. Eriksson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ras and Nox: Linked signaling networks?

(2009) Ru Feng Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cancer associated fibroblasts (CAFs) in tumor microenvironment

(2009) Fei Xing   Frontiers in Bioscience-Landmark

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia

(2009) Petr Ježek et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Downregulation of thec-MYCtarget gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia

(2009) Pablo E. Vivas-Mejía et al.   INTERNATIONAL JOURNAL OF CANCER

Peroxiredoxin IV Protects Cells From Radiation-Induced Apoptosis in Head-and-Neck Squamous Cell Carcinoma

(2009) Jung Je Park et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiosensitive gene therapy through imRNA expression for silencing manganese superoxide dismutase

(2009) Yaming Qu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Hypoxia-inducible factors in stem cells and cancer

(2009) Jolly Mazumdar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

(2009) Jian-Ming Lü et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

Suppression of Cancer Growth by Nonviral Gene Therapy Based on a Novel Reactive Oxygen Species-responsive Promoter

(2009) Lucía L Policastro et al.   MOLECULAR THERAPY

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Peroxiredoxin I plays a protective role against cisplatin cytotoxicity through mitogen activated kinase signals

(2009) Dongmei Ma et al.   ORAL ONCOLOGY

Akt1 Intramitochondrial Cycling Is a Crucial Step in the Redox Modulation of Cell Cycle Progression

(2009) Valeria Gabriela Antico Arciuch et al.   PLoS One

Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites

(2009) E. Klotzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential

(2009) L. Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases RadioresistanceIn VitroandIn Vivo

(2009) Michael W. Epperly et al.   RADIATION RESEARCH

Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress

(2009) Mark W. Dewhirst   RADIATION RESEARCH

Overexpression of Prdx6 and resistance to peroxide-induced death in Hepa1-6 cells: Prdx suppression increases apoptosis

(2009) Bridget Walsh et al.   REDOX REPORT

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

(2009) B. Diaz et al.   Science Signaling

Origin and function of tumor stroma fibroblasts

(2009) Georgia Xouri et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Thioredoxin reductase 1 ablation sensitizes colon cancer cells to methylseleninate-mediated cytotoxicity

(2009) Matthew Honeggar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adenovirus receptors and their implications in gene delivery

(2009) Anurag Sharma et al.   VIRUS RESEARCH

Structural Adaptation and Heterogeneity of Normal and Tumor Microvascular Networks

(2009) Axel R. Pries et al.   PLoS Computational Biology

Matricellular proteins: an overview

(2009) Paul Bornstein   Journal of Cell Communication and Signaling

Alterations of Cellular Redox State During NNK-Induced Malignant Transformation and Resistance to Radiation

(2008) Yusuke Demizu et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

(2008) Randall S. Frey et al.   ANTIOXIDANTS & REDOX SIGNALING

Evaluation of Oxidative Stress in Colorectal Cancer Patients

(2008) DONG CHANG et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2

(2008) B H Y Yeung et al.   BRITISH JOURNAL OF CANCER

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

(2008) Masuko Ushio-Fukai et al.   CANCER LETTERS

Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice

(2008) A. Banning et al.   CANCER RESEARCH

Tumor Escape Mechanism Governed by Myeloid-Derived Suppressor Cells

(2008) S. Nagaraj et al.   CANCER RESEARCH

RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy

(2008) A. Singh et al.   CANCER RESEARCH

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial complex III regulates hypoxic activation of HIF

(2008) T Klimova et al.   CELL DEATH AND DIFFERENTIATION

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages

(2008) Paola Allavena et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Determinants of urinary 8-hydroxy-2′-deoxyguanosine in Chinese children with acute leukemia

(2008) You Yang et al.   ENVIRONMENTAL TOXICOLOGY

A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells

(2008) A BORRELLI et al.   FREE RADICAL BIOLOGY AND MEDICINE

The radiation-inducible pE9 promoter driving inducible nitric oxide synthase radiosensitizes hypoxic tumour cells to radiation

(2008) J A Coulter et al.   GENE THERAPY

Oxidative stress-inducible lentiviral vectors for gene therapy

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Should Supplemental Antioxidant Administration Be Avoided During Chemotherapy and Radiation Therapy?

(2008) B. D. Lawenda et al.   JNCI-Journal of the National Cancer Institute

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

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(2008) Jorge Limón-Pacheco et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Pyruvate kinase M2 is a phosphotyrosine-binding protein

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Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+

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(2008) P. Vaupel   ONCOLOGIST

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ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

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PPARγand Proline Oxidase in Cancer

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Adenovirus-mediated transfer of siRNA against peroxiredoxin I enhances the radiosensitivity of human intestinal cancer

(2007) Bo Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth

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