Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 47, Issue 9, Pages 1276-1281Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2009.05.037
Keywords
Reactive oxidant species (ROS); Signal transduction; NADPH oxidase; Transformation; Apoptosis; MAPK
Funding
- NHLBI [R01-HL061897, R01-HL067256]
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Both Ras and Nox represent ancient gene families which control a broad range of cellular responses. Both families mediate signals governing motility. differentiation, and proliferation, and both inhabit overlapping subcellular microdomains. Yet little is known of the precise functional relationship between these two ubiquitous families. In this review. we examine the interface where these two large fields meet. (C) 2009 Elsevier Inc. All rights reserved.
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