Redox-Regulated Growth Factor Survival Signaling

Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ

(2012) R. Godfrey et al.   BLOOD

Identification of a redox-sensitive switch within the JAK2 catalytic domain

(2012) John K. Smith et al.   FREE RADICAL BIOLOGY AND MEDICINE

Constitutive NADPH Oxidase 4 Activity Resides in the Composition of the B-loop and the Penultimate C Terminus

(2012) Katharina von Löhneysen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of a Peroxiredoxin by Hydrogen Peroxide Is Critical for Thioredoxin-Mediated Repair of Oxidized Proteins and Cell Survival

(2012) Alison M. Day et al.   MOLECULAR CELL

H2O2 Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling

(2012) John F. Woolley et al.   PLoS One

Molecular regulation of NADPH oxidase 5 via the MAPK pathway

(2011) D. Pandey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors

(2011) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome”

(2011) Robert Karisch et al.   CELL

Reactive oxygen species regulate M-CSF-induced monocyte/macrophage proliferation through SHP1 oxidation

(2011) Han Kyoung Choi et al.   CELLULAR SIGNALLING

Hyperglycemia Enhances IGF-I-Stimulated Src Activation via Increasing Nox4-Derived Reactive Oxygen Species in a PKC -Dependent Manner in Vascular Smooth Muscle Cells

(2011) G. Xi et al.   DIABETES

Thiol-protease oxidation in age-related neuropathology

(2011) Rodney P. Guttmann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo

(2011) Alison C. Brewer et al.   FREE RADICAL BIOLOGY AND MEDICINE

15-Lipoxygenase-1-enhanced Src-Janus Kinase 2-Signal Transducer and Activator of Transcription 3 Stimulation and Monocyte Chemoattractant Protein-1 Expression Require Redox-sensitive Activation of Epidermal Growth Factor Receptor in Vascular Wall Remodeling

(2011) Nikhlesh K. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface

(2011) K. Palande et al.   JOURNAL OF CELL SCIENCE

Dual Oxidase 1 Induced by Th2 Cytokines Promotes STAT6 Phosphorylation via Oxidative Inactivation of Protein Tyrosine Phosphatase 1B in Human Epidermal Keratinocytes

(2011) S. Hirakawa et al.   JOURNAL OF IMMUNOLOGY

NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II

(2011) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Peroxiredoxin II Is an Essential Antioxidant Enzyme that Prevents the Oxidative Inactivation of VEGF Receptor-2 in Vascular Endothelial Cells

(2011) Dong Hoon Kang et al.   MOLECULAR CELL

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

Direct Sensing of Endothelial Oxidants by Vascular Endothelial Growth Factor Receptor-2 and c-Src

(2011) Monica Lee et al.   PLoS One

Hydrogen peroxide: a Jekyll and Hyde signalling molecule

(2011) D R Gough et al.   Cell Death & Disease

Multiple Functions of Peroxiredoxins: Peroxidases, Sensors and Regulators of the Intracellular Messenger H2O2, and Protein Chaperones

(2010) Sue Goo Rhee et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Control of GTPases: From Molecular Mechanisms to Functional Significance in Health and Disease

(2010) Jongyun Heo   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling

(2010) Michel Rigoulet et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-κB in human aortic smooth muscle cells

(2010) Adrian Manea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reactive oxygen species derived from Nox4 mediateBMP2gene transcription and osteoblast differentiation

(2010) Chandi C. Mandal et al.   BIOCHEMICAL JOURNAL

Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3

(2010) L. Li et al.   CANCER RESEARCH

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation

(2010) Davide Gianni et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Src redox regulation: Again in the front line

(2010) Elisa Giannoni et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidase 4 mediates TGF-β-induced smooth muscle α-actin via p38MAPK and serum response factor

(2010) Abel Martin-Garrido et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox Regulation of Lipopolysaccharide-mediated Sulfiredoxin Induction, Which Depends on Both AP-1 and Nrf2

(2010) Hojin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase Activation in Pancreatic Cancer Cells Is Mediated through Akt-dependent Up-regulation of p22phox

(2010) Mouad Edderkaoui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Modification of Nuclear Mitogen-activated Protein Kinase Phosphatase 1 Is Involved in Transforming Growth Factor β1-induced Expression of Plasminogen Activator Inhibitor 1 in Fibroblasts

(2010) Rui-Ming Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Evidence that Peroxiredoxin Catalytic Power Is Based on Transition-State Stabilization

(2010) Andrea Hall et al.   JOURNAL OF MOLECULAR BIOLOGY

c-Src–Mediated Phosphorylation of NoxA1 and Tks4 Induces the Reactive Oxygen Species (ROS)–Dependent Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   MOLECULAR BIOLOGY OF THE CELL

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

(2010) M. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

(2010) E. W. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen Peroxide as a Cell-Survival Signaling Molecule

(2009) Gillian Groeger et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging Evidence for the Importance of Phosphorylation in the Regulation of NADPH Oxidases

(2009) Gary M. Bokoch et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of NF-κB by Palmitate in Endothelial Cells

(2009) Ezekiel Maloney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Typical 2-Cys peroxiredoxins - modulation by covalent transformations and noncovalent interactions

(2009) Martin Aran et al.   FEBS Journal

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

(2009) R Naughton et al.   LEUKEMIA

Novel p47phox-Related Organizers Regulate Localized NADPH Oxidase 1 (Nox1) Activity

(2009) D. Gianni et al.   Science Signaling

Endosomal Nox2 Facilitates Redox-Dependent Induction of NF-κB by TNF-α

(2008) Qiang Li et al.   ANTIOXIDANTS & REDOX SIGNALING

A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72

(2008) Wei Chen et al.   BIOCHEMICAL JOURNAL

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras

(2008) Eunice Laurent et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of ROS signal transduction by NADPH oxidase 4 localization

(2008) Kai Chen et al.   JOURNAL OF CELL BIOLOGY

A new redox-dependent mechanism of MMP-1 activity control comprising reduced low-molecular-weight thiols and oxidizing radicals

(2008) Sabine Koch et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

(2008) J. C. Juarez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA