Article
Cell Biology
Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martin Silva, Kevin Regan, Elisabet Cuyas, X. Wei Meng, Sara Verdura, Aina Arbusa, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez, Ruth Lupu
Summary: Inhibiting FASN can enhance mitochondrial apoptotic priming in cancer cells, controlling cell survival through BH3-only proteins and sensitizing cells to BCL-2-specific BH3 mimetics. Combining FASN inhibitors with BCL-2-specific BH3 mimetics could potentially generate more potent antitumor responses.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Gabriele Bluemel, Melanie Planque, Corina T. Madreiter-Sokolowski, Theresa Haitzmann, Andelko Hrzenjak, Wolfgang F. Graier, Sarah-Maria Fendt, Horst Olschewski, Katharina Leithner
Summary: PCK2 acts as a regulator of mitochondrial respiration and maintains redox balance in nutrient-deprived cancer cells. Inhibition of PCK2 significantly reduces colony formation of lung cancer cells under starvation, showing its potential as a therapeutic target.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Austin C. Boese, Sumin Kang
Summary: Cancer cells exhibit abnormal metabolic activity, often preferring aerobic glycolysis, and mitochondrial metabolic pathways are also reprogrammed in cancer. Cancer cells have higher levels of reactive oxygen species compared to non-cancerous cells and must employ diverse metabolic strategies to prevent oxidative stress.
Article
Biology
Madeleine L. Hart, Evan Quon, Anna-Lena B. G. Vigil, Ian A. Engstrom, Oliver J. Newsom, Kristian Davidsen, Pia Hoellerbauer, Samantha M. Carlisle, Lucas B. Sullivan
Summary: The oxidative tricarboxylic acid (TCA) cycle is a crucial pathway for cell proliferation that involves the conversion of NAD+ to NADH and the production of aspartate. The loss of SDH, a component of the TCA cycle, is implicated in tumorigenesis, but the mechanism by which proliferating cells tolerate SDH loss is not well understood. This study identifies that SDH supports cell proliferation through aspartate synthesis and shows that concomitant inhibition of ETC complex I can restore aspartate production and cell proliferation in SDH-impaired cells. These findings highlight the metabolic mechanisms that cells use to maintain aspartate synthesis and reveal the impact of compartmentalized redox changes on cellular fitness.
Review
Physiology
Brigitta Buttari, Marzia Arese, Rebecca E. Oberley-Deegan, Luciano Saso, Arpita Chatterjee
Summary: Metabolic alterations are common survival mechanism for prostate cancer, with oxidative stress in the cellular and tumor microenvironment dictating metabolic switching in cancer cells. Regulation of oxidative stress may enhance conventional anticancer therapies.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Feroza K. Choudhury
Summary: Mitochondrial redox metabolism plays a crucial role in cancer progression, regulating metabolic adaptation and maintaining cellular redox homeostasis. The flexibility of mitochondrial metabolism is essential for cancer cells to adapt to new environments and overcome metabolic limitations, especially during different stages of metastasis.
Review
Biochemistry & Molecular Biology
Dane T. Sessions, David F. Kashatus
Summary: Many tumors are heterogeneous cell populations composed of a minority of epithelial-like cancer stem cells (CSCs), which exhibit distinct metabolic signatures and phenotypes arising from altered mitochondrial function and turnover regulated by constant cycles of fusion and fission. The protein machinery driving mitochondrial dynamics is relatively simple, providing potential new therapeutic avenues to target CSC metabolism and selectively eradicate tumor-generating cells to reduce the risks of metastasis and relapse. Mitochondrial recycling through mitophagy in CSCs is associated with the maintenance of reactive oxygen species levels that dictate gene expression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Michelle S. Prew, Utsarga Adhikary, Dong Wook Choi, Erika P. Portero, Joao A. Paulo, Pruthvi Gowda, Amit Budhraja, Joseph T. Opferman, Steven P. Gygi, Nika N. Danial, Loren D. Walensky
Summary: MCL-1 is essential for the survival of various cell types and plays a major role in cancer and chemoresistance. This study reveals that MCL-1-dependent cancer cells rely on fatty acid oxidation (FAO) as their main fuel source. The regulation of FAO by MCL-1 is independent of its anti-apoptotic activity, and targeting FAO pathway may be an effective treatment strategy for MCL-1-driven cancers.
Article
Multidisciplinary Sciences
Maowu Luo, Lei Bao, Yan Chen, Yuanyuan Xue, Yong Wang, Bo Zhang, Chenliang Wang, Chase D. Corley, Jeffrey G. McDonald, Ashwani Kumar, Chao Xing, Yisheng Fang, Erik R. Nelson, Jennifer E. Wang, Yingfei Wang, Weibo Luo
Summary: The histone reader ZMYND8 is selectively expressed in breast cancer stem cells (BCSCs) and promotes breast tumor initiation through its epigenetic functions by regulating 27-HC metabolism, leading to the accumulation of 27-HC in BCSCs and activation of liver X receptor.
Article
Nutrition & Dietetics
Juan Carlos Borquez, Miltha Hidalgo, Juan M. Rodriguez, Alejandra Montana, Omar Porras, Rodrigo Troncoso, Roberto Bravo-Sagua
Summary: Short-term exposure to low doses of sucralose can increase mitochondrial respiratory activity and enhance cellular reductive power in Caco-2 cells. These findings suggest that sucralose alters enterocyte energy homeostasis, contributing to its effects on organismal metabolism.
FRONTIERS IN NUTRITION
(2021)
Article
Biotechnology & Applied Microbiology
Yun Zhang, Zhe Liu, Xueliang Wang, Hui Jian, Haihan Xiao, Tingyi Wen
Summary: Mitochondrial serine hydroxymethyltransferase (SHMT2) supports the proliferation of bladder cancer cells by maintaining redox homeostasis and its deficiency triggers cell apoptosis through ROS-dependent, mitochondrial-mediated pathways.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Valerie Vinette, Isabelle Aubry, Hayley Insull, Noriko Uetani, Serge Hardy, Michel L. Tremblay
Summary: Metabolic reprogramming in cancer cells is regulated by tyrosine kinases and tyrosine phosphatases. Among the protein tyrosine phosphatase (PTP) superfamily, TC-PTP (PTPN2) has been identified as a key regulator of mitochondrial metabolism in cancer cells, with its inhibition resulting in functional defects in oxidative metabolism.
Review
Immunology
Aswath P. P. Chandrasekar, Andrew D. D. Badley
Summary: This minireview explores the potential of BCL-2 inhibition as a method to enhance the shock and kill strategy for HIV cure, by investigating its role in infected cell survival, latency reversal, and immune evasion. The study highlights the suboptimal results achieved so far in HIV therapy and the importance of targeting the BCL-2 anti-apoptotic protein for effective viral clearance. Future research in this area could potentially lead to a cure for HIV.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Hyunbae Kim, Zhiyao Fu, Zhao Yang, Zhenfeng Song, El Hussain Shamsa, Thangal Yumnamcha, Shengyi Sun, Wanqing Liu, Ahmed S. Ibrahim, Nathan R. Qi, Ren Zhang, Kezhong Zhang
Summary: The mitochondrial nicotinamide adenine dinucleotide kinase (MNADK) plays an important role in regulating energy metabolism and maintaining metabolic homeostasis. MNADK deficiency is associated with metabolic diseases such as type-2 diabetes, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Loss of MNADK reduces fat oxidation and energy expenditure, and leads to hepatic insulin resistance and glucose intolerance. Moreover, MNADK deficiency results in decreased mitochondrial NADP(H) and increased cellular reactive oxygen species.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Renyi Wu, Shanyi Li, Rasika Hudlikar, Lujing Wang, Ahmad Shannar, Rebecca Peter, Pochung Jordan Chou, Hsiao-Chen Dina Kuo, Zhigang Liu, Ah-Ng Kong
Summary: Biological redox signaling plays a crucial role in diseases by affecting cellular redox balance and gene expression. It interacts with mitochondrial metabolism and epigenetics. Certain phytochemicals possess both antioxidant and epigenetic modifying abilities, making them potentially beneficial for human health.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
S. Seah, I. C. C. Low, J. L. Hirpara, K. Sachaphibulkij, G. Kroemer, C. Brenner, S. Pervaiz
CELL DEATH & DISEASE
(2015)
Review
Sport Sciences
X. R. Tan, I. C. C. Low, M. C. Stephenson, T. W. Soong, J. K. W. Lee
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2018)
Article
Biochemistry & Molecular Biology
Ivan Cherh Chiet Low, Zhi Xiong Chen, Shazib Pervaiz
ANTIOXIDANTS & REDOX SIGNALING
(2010)
Review
Biochemistry & Molecular Biology
Shefali Krishna, Ivan Cherh Chiet Low, Shazib Pervaiz
BIOCHEMICAL JOURNAL
(2011)
Article
Hematology
Ivan Cherh Chiet Low, Thomas Loh, Yiqing Huang, David M. Virshup, Shazib Pervaiz
Article
Cell Biology
Stephen Jun Fei Chong, Ivan Cherh Chiet Low, Shazib Pervaiz
Article
Biochemistry & Molecular Biology
G. S. Coombs, A. A. Schmitt, C. A. Canning, A. Alok, I. C. C. Low, N. Banerjee, S. Kaur, V. Utomo, C. M. Jones, S. Pervaiz, E. J. Toone, D. M. Virshup
Article
Physiology
X. R. Tan, I. C. C. Low, M. C. Stephenson, T. Kok, H. W. Nolte, T. W. Soong, J. K. W. Lee
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Health Care Sciences & Services
Andre Matthias Mueller, Nan Xin Wang, Jiali Yao, Chuen Seng Tan, Ivan Cherh Chiet Low, Nicole Lim, Jeremy Tan, Agnes Tan, Falk Mueller-Riemenschneider
JMIR MHEALTH AND UHEALTH
(2019)
Review
Biochemical Research Methods
Chee Chong Shawn Tan, Li Kang Karen Chin, Ivan Cherh Chiet Low
Article
Sport Sciences
Sharifah B. Alhadad, Ivan C. C. Low, Jason K. W. Lee
Summary: Ice slurry ingestion during low-intensity exercise can reduce thermal strain, but it has limited effect during moderate-intensity exercise. Ice slurry may be an effective heat mitigation strategy in low-intensity exercise settings.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Article
Biochemistry & Molecular Biology
Stephen Jun Fei Chong, Kartini Iskandar, Jolin Xiao Hui Lai, Jianhua Qu, Deepika Raman, Rebecca Valentin, Charles Herbaux, Mary Collins, Ivan Cherh Chiet Low, Thomas Loh, Matthew Davids, Shazib Pervaiz
NUCLEIC ACIDS RESEARCH
(2020)
Article
Sport Sciences
Xiang Ren Tan, Ivan Cherh Chiet Low, Chris Byrne, Ru Wang, Jason Kai Wei Lee
Summary: The study aimed to assess the level of dehydration in elite runners following a city marathon in a tropical environment and found an average dehydration rate of 4.6%, exceeding the ACSM recommended 2%. Despite higher dehydration levels, male and female runners performed successfully without medical complications during the race.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Article
Education, Scientific Disciplines
Amanda Huee-Ping Wong, Lik-Wei Wong, Ivan Cherh Chiet Low
Summary: This study assessed the impact of a remote practical assisted by physiological monitoring smartphone applications on student motivation and the achievement of learning outcomes. The results showed that the remote practical facilitated the achievement of learning outcomes and enhanced student motivation.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)