Broad Coverage of Genetically Diverse Strains of Clostridium difficile by Actoxumab and Bezlotoxumab Predicted byIn VitroNeutralization and Epitope Modeling

International typing study of Clostridium difficile

(2014) Carl E. Manzo et al.   ANAEROBE

Mechanisms of Protection against Clostridium difficile Infection by the Monoclonal Antitoxin Antibodies Actoxumab and Bezlotoxumab

(2014) Zhiyong Yang et al.   INFECTION AND IMMUNITY

Mechanism of Action and Epitopes ofClostridium difficileToxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

(2014) Peter Orth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels ofIn VitroPotency ShowsIn VivoProtection in a Hamster Infection Model

(2013) Nicola L. Davies et al.   Clinical and Vaccine Immunology

Relationship Between Bacterial Strain Type, Host Biomarkers, and Mortality in Clostridium difficile Infection

(2013) A. Sarah Walker et al.   CLINICAL INFECTIOUS DISEASES

Epidemiology, diagnosis and treatment ofClostridium difficileinfection

(2012) Matteo Bassetti et al.   Expert Review of Anti-Infective Therapy

Antibody Against TcdB, but Not TcdA, Prevents Development of Gastrointestinal and Systemic Clostridium difficile Disease

(2012) Jennifer Steele et al.   JOURNAL OF INFECTIOUS DISEASES

Protection Against Clostridium difficile Infection With Broadly Neutralizing Antitoxin Monoclonal Antibodies

(2012) Andre J. Marozsan et al.   JOURNAL OF INFECTIOUS DISEASES

Clostridium difficile Toxins: Mediators of Inflammation

(2012) Aimee Shen   Journal of Innate Immunity

Toward a structural understanding of Clostridium difficile toxins A and B

(2012) Rory N. Pruitt et al.   Frontiers in Cellular and Infection Microbiology

The role of toxin A and toxin B in the virulence of Clostridium difficile

(2011) Glen P. Carter et al.   TRENDS IN MICROBIOLOGY

Typing of Clostridium difficile isolates endemic in Japan by sequencing of slpA and its application to direct typing

(2010) H. Kato et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Clostridium difficile infection in Europe: a hospital-based survey

(2010) Martijn P Bauer et al.   LANCET

Treatment with Monoclonal Antibodies againstClostridium difficileToxins

(2010) Israel Lowy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clostridium difficile Infection Caused by the Epidemic BI/NAP1/027 Strain

(2009) Jennifer R. O'Connor et al.   GASTROENTEROLOGY

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY