Mechanisms of Protection against Clostridium difficile Infection by the Monoclonal Antitoxin Antibodies Actoxumab and Bezlotoxumab

Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile

(2014) Robert A. Britton et al.   GASTROENTEROLOGY

Mechanism of Action and Epitopes ofClostridium difficileToxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

(2014) Peter Orth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice

(2014) Zhiyong Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Human Monoclonal Antibodies against Clostridium difficile Toxins A and B Inhibit Inflammatory and Histologic Responses to the Toxins in Human Colon and Peripheral Blood Monocytes

(2013) Hon Wai Koon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Decreased Cure and Increased Recurrence Rates for Clostridium difficile Infection Caused by the Epidemic C. difficile BI Strain

(2012) Laurica A. Petrella et al.   CLINICAL INFECTIOUS DISEASES

A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection

(2012) Haiying Wang et al.   INFECTION AND IMMUNITY

Association of Relapse of Clostridium difficile Disease with BI/NAP1/027

(2012) J. W. Marsh et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Crosstalk between Human IgG Isotypes and Murine Effector Cells

(2012) M. B. Overdijk et al.   JOURNAL OF IMMUNOLOGY

Antibody Against TcdB, but Not TcdA, Prevents Development of Gastrointestinal and Systemic Clostridium difficile Disease

(2012) Jennifer Steele et al.   JOURNAL OF INFECTIOUS DISEASES

Clostridium difficile Toxins: Mediators of Inflammation

(2012) Aimee Shen   Journal of Innate Immunity

Immune responses to Clostridium difficile infection

(2012) Rajat Madan et al.   TRENDS IN MOLECULAR MEDICINE

Cytotoxicity ofClostridium difficiletoxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol

(2012) Shan Li et al.   Pathogens and Disease

Mouse Relapse Model of Clostridium difficile Infection

(2011) Xingmin Sun et al.   INFECTION AND IMMUNITY

Evidence of intravenous immunoglobulin as a critical supportive therapy against Clostridium difficile toxin-mediated lethality in mice

(2011) T. Saito et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Systemic Dissemination of Clostridium difficile Toxins A and B Is Associated With Severe, Fatal Disease in Animal Models

(2011) Jennifer Steele et al.   JOURNAL OF INFECTIOUS DISEASES

Intravenous Immunoglobulin for the Treatment of Clostridium difficile Infection: A Review

(2010) Marwan S. Abougergi et al.   DIGESTIVE DISEASES AND SCIENCES

Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)

(2010) Stuart H. Cohen et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Treatment with Monoclonal Antibodies againstClostridium difficileToxins

(2010) Israel Lowy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single Immunoglobulin Infusion Can Reverse Hemodynamic Failure Associated With Severe Clostridium difficile Colitis

(2009) Harry Sokol et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A 69-Year-Old Woman Presenting to the Hospital With 48 Hours of Abdominal Pain and Diarrhea

(2009) Daniel A. Leffler et al.   Clinical Gastroenterology and Hepatology

Recurrent Clostridium difficile infection: causality and therapeutic approaches

(2009) Stuart Johnson   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins

(2009) Xiangyun He et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI)

(2009) Brett A. Leav et al.   VACCINE

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium

(2008) Guilin Yang et al.   BMC MICROBIOLOGY

A Mouse Model of Clostridium difficile–Associated Disease

(2008) Xinhua Chen et al.   GASTROENTEROLOGY

Clostridium difficile— More Difficult Than Ever

(2008) Ciarán P. Kelly et al.   NEW ENGLAND JOURNAL OF MEDICINE