Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase

Expression of an Mg2+-Dependent HIV-1 RNase H Construct for Drug Screening

(2011) Richard V. Farias et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid andN-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

(2011) Eric B. Lansdon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus

(2011) Yue-Lei Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase

(2011) Jing Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase

(2011) Jing Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

(2011) Suhman Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function

(2011) Muriel Billamboz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase

(2011) Tanyaradzwa P. Ndongwe et al.   NUCLEIC ACIDS RESEARCH

K70Q Adds High-Level Tenofovir Resistance to “Q151M Complex” HIV Reverse Transcriptase through the Enhanced Discrimination Mechanism

(2011) Atsuko Hachiya et al.   PLoS One

Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

(2010) S. Chung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold

(2010) Peter D. Williams et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Interaction of HIV-1 Reverse Transcriptase Ribonuclease H with an Acylhydrazone Inhibitor

(2010) Qingguo Gong et al.   Chemical Biology & Drug Design

The N348I Mutation at the Connection Subdomain of HIV-1 Reverse Transcriptase Decreases Binding to Nevirapine

(2010) Matthew M. Schuckmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing the Molecular Interactions of a Nucleotide Analog, GS-9148, with HIV-1 Reverse Transcriptase–DNA Complex

(2010) Eric B. Lansdon et al.   JOURNAL OF MOLECULAR BIOLOGY

Multiple Nucleotide Preferences Determine Cleavage-Site Recognition by the HIV-1 and M-MuLV RNases H

(2010) Sharon J. Schultz et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of Xenotropic Murine Leukemia Virus-Related Virus by APOBEC3 Proteins and Antiviral Drugs

(2010) T. Paprotka et al.   JOURNAL OF VIROLOGY

Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

(2010) H.-P. Su et al.   JOURNAL OF VIROLOGY

Structural basis of HIV-1 resistance to AZT by excision

(2010) Xiongying Tu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibitors of Foot and Mouth Disease Virus Targeting a Novel Pocket of the RNA-Dependent RNA Polymerase

(2010) Ryan C. Durk et al.   PLoS One

HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors

(2010) Greg L. Beilhartz et al.   Viruses-Basel

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

(2010) Kamalendra Singh et al.   Viruses-Basel

N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase

(2010) Jing Tang et al.   ACS Medicinal Chemistry Letters

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase Inhibitor

(2009) Eleftherios Michailidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information

(2009) Thorsten A. Kirschberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Derivatives of 5-Nitro-furan-2-carboxylic Acid Carbamoylmethyl Ester Inhibit RNase H Activity Associated with HIV-1 Reverse Transcriptase

(2009) Hideyoshi Fuji et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

(2009) Greg L. Beilhartz et al.   JOURNAL OF MOLECULAR BIOLOGY

“Conditional Restraints”: Restraining the Free Atoms in ARP/wARP

(2009) Wijnand T.M. Mooij et al.   STRUCTURE

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

(2009) Daniel M. Himmel et al.   STRUCTURE

Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity

(2008) Michaela Wendeler et al.   ACS Chemical Biology

Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms

(2008) Maryam Ehteshami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of a Series of 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain

(2008) Muriel Billamboz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

(2008) Stefan G. Sarafianos et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 Ribonuclease H Inhibitory Phenolic Glycosides fromEugenia hyemalis

(2008) Heidi R. Bokesch et al.   JOURNAL OF NATURAL PRODUCTS

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

(2008) Joseph D. Bauman et al.   NUCLEIC ACIDS RESEARCH

Murine leukemia virus reverse transcriptase: Structural comparison with HIV-1 reverse transcriptase

(2008) Marie L. Coté et al.   VIRUS RESEARCH