HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors
Published 2010 View Full Article
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Title
HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors
Authors
Keywords
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Journal
Viruses-Basel
Volume 2, Issue 4, Pages 900-926
Publisher
MDPI AG
Online
2010-03-30
DOI
10.3390/v2040900
References
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Related references
Note: Only part of the references are listed.- Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients
- (2009) Atsuko Hachiya et al. ANTIVIRAL RESEARCH
- Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription
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- Preferred Sequences within a Defined Cleavage Window Specify DNA 3′ End-directed Cleavages by Retroviral RNases H
- (2009) Sharon J. Schultz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information
- (2009) Thorsten A. Kirschberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition
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- Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site
- (2009) Daniel M. Himmel et al. STRUCTURE
- Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity
- (2008) Michaela Wendeler et al. ACS Chemical Biology
- Mechanism by which a Glutamine to Leucine Substitution at Residue 509 in the Ribonuclease H Domain of HIV-1 Reverse Transcriptase Confers Zidovudine Resistance†
- (2008) Jessica H. Brehm et al. BIOCHEMISTRY
- Mutagenesis of Gln294 of the reverse transcriptase of human immunodeficiency virus type-2 and its effects on the ribonuclease H activity
- (2008) R. Bochner et al. FEBS LETTERS
- Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV
- (2008) Erik De Clercq INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms
- (2008) Maryam Ehteshami et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
- (2008) A. Hachiya et al. JOURNAL OF VIROLOGY
- Dynamic binding orientations direct activity of HIV reverse transcriptase
- (2008) Elio A. Abbondanzieri et al. NATURE
- Conservation Patterns of HIV-1 RT Connection and RNase H Domains: Identification of New Mutations in NRTI-Treated Patients
- (2008) André F. A. Santos et al. PLoS One
- HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision
- (2008) K. A. Delviks-Frankenberry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNase H activity: Structure, specificity, and function in reverse transcription
- (2008) Sharon J. Schultz et al. VIRUS RESEARCH
- Murine leukemia virus reverse transcriptase: Structural comparison with HIV-1 reverse transcriptase
- (2008) Marie L. Coté et al. VIRUS RESEARCH
- Strand transfer events during HIV-1 reverse transcription
- (2008) Vandana Purohit Basu et al. VIRUS RESEARCH
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