Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Saida Mebarek, Najwa Skafi, Leyre Brizuela
Summary: Prostate cancer is the second most common cancer in men worldwide, with the majority of patients being above 65. Sphingosine 1-phosphate (S1P) is a bioactive lipid that plays a crucial role in the oncogenesis of prostate cancer. S1P metabolism and its enzymes have been extensively studied in relation to prostate cancer development and potential therapeutic targets. This review summarizes the significant findings and the current progress in targeting S1P metabolism for prostate cancer treatment.
Article
Biochemistry & Molecular Biology
Rosaria Bassi, Stefania Brambilla, Cristina Tringali, Paola Giussani
Summary: The study found that GBM cells overexpressing EGFR have higher levels of S1P and increased SK1 activity, leading to resistance to the standard chemotherapeutic drug temozolomide. This suggests a functional link between EGFR and S1P signaling pathways in enhancing the survival properties of GBM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Preeti Gupta, Aaliya Taiyab, Afzal Hussain, Mohamed F. Alajmi, Asimul Islam, Md. Imtaiyaz Hassan
Summary: Cancer is a leading cause of global mortality, with SphK1 and its metabolite S1P being potential therapeutic targets due to their over-expression in various cancers and metabolic disorders. This review discusses the sphingolipid metabolism and the role of SphK isoforms in human malignancies, as well as the potential of SphK inhibitors in cancer therapy. It highlights the importance of sphingolipid metabolites in regulating physiological processes and the significance of the SphK/S1P signaling axis in human pathologies.
Review
Virology
Lu Zhang, Juan Liu, Erya Xiao, Qingzhen Han, Lin Wang
Summary: Viruses can create a unique cellular environment that facilitates replication and transmission. The SphK/S1P axis plays a crucial role in regulating cellular activities during viral infections. Depending on the type of virus, the SphK/S1P axis can have pro- or anti-viral activities through the host immune system or intracellular signaling pathways and cell proliferation.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Endocrinology & Metabolism
David Montefusco, Maryam Jamil, Melissa A. Maczis, William Schroeder, Moshe Levi, Suman Ranjit, Jeremy Allegood, Dipankar Bandyopadhyay, Reuben Retnam, Sarah Spiegel, L. Ashley Cowart
Summary: Men with NAFLD are more likely to progress to NASH and liver fibrosis than women. This study revealed a novel pathway involving estrogen-mediated cross-talk between hepatocytes and HSCs that may contribute to sex differences in NAFLD through the anti-fibrogenic function of the S1P/S1PR3 axis.
MOLECULAR METABOLISM
(2022)
Article
Obstetrics & Gynecology
Caterina Bernacchioni, Pasquapina Ciarmela, Valentina Vannuzzi, Stefania Greco, Silvia Vannuccini, Francesca Malentacchi, Pamela Pellegrino, Tommaso Capezzuoli, Flavia Sorbi, Francesca Cencetti, Paola Bruni, Chiara Donati, Felice Petraglia
Summary: The study revealed that S1P signaling is dysregulated in uterine fibroids and involved in activin A-induced fibrosis, presenting new perspectives for the treatment of uterine fibroids.
FERTILITY AND STERILITY
(2021)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal
Summary: The role of sphingosine kinase 1 (SphK1) in corneal neovascularization (NV) was investigated. The study showed that ablation of SphK1 can significantly reduce NV invasion in the cornea following injury. Furthermore, sphingolipid analysis revealed lower levels in Sphk1(-/-) corneas after injury.
Article
Cell Biology
Chiara D'Aprile, Simona Prioni, Laura Mauri, Alessandro Prinetti, Sara Grassi
Summary: Lipid rafts are specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol, and proteins involved in signal transduction, modulating cell homeostasis. Sphingosine 1-phosphate participates in various signal transduction processes, with enzymes and receptors often localized in lipid rafts.
CELLULAR SIGNALLING
(2021)
Review
Oncology
Antonia Piazzesi, Sumaiya Yasmeen Afsar, Gerhild Van Echten-Deckert
Summary: Cancer development is a complex process involving overcoming obstacles such as unrestricted proliferation, invasion, nutrient supply, and metastasis, while evading the immune system. Inflammation plays a role in cancer development, with sphingolipid metabolism impacting cells' progression from healthy to cancerous phenotypes.
MOLECULAR ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nader Hamdan, Anjali Y. Bhagirath, Eraldo L. Batista
Summary: This study evaluated the changes in Sphingosine-1-Phosphate (S1P) levels and Sphingosine Kinase (SPHK) activity in response to non-surgical periodontal treatment. The results showed that non-surgical treatment led to a decrease in SPHK activity and S1P levels, which correlated with improvements in periodontal parameters. Specifically, SPHK1 levels significantly decreased after periodontal treatment.
Article
Oncology
Vikas Satyananda, Masanori Oshi, Yoshihisa Tokumaru, Aparna Maiti, Nitai Hait, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Summary: High S1P export, driven by the simultaneous high expression of SphK1 and ABCC1, is associated with enhanced HCC progression and immune response, leading to significantly worse disease-specific survival and overall survival outcomes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Fei Li, Yifan Zhang, Zhoujun Lin, Lizhong Yan, Qiao Liu, Yin Li, Xiaolin Pei, Ya Feng, Xiao Han, Juan Yang, Fangxu Zheng, Tianjiao Li, Yupeng Zhang, Zhenkun Fu, Di Shao, Jane Yu, Chenggang Li
Summary: This study identified rapamycin-insensitive sphingosine metabolic signatures in LAM cells and demonstrated that therapeutic targeting of aberrant SPHK1/S1P/S1PR3 signaling may have potent therapeutic benefit for patients with TSC/LAM or other hyperactive mTOR neoplasms with autophagy inhibition.
CELL DEATH & DISEASE
(2022)
Article
Obstetrics & Gynecology
Caterina Bernacchioni, Tommaso Capezzuoli, Valentina Vannuzzi, Francesca Malentacchi, Francesca Castiglione, Francesca Cencetti, Marcello Ceccaroni, Chiara Donati, Paola Bruni, Felice Petraglia
Summary: This study investigates the molecular mechanisms involved in the fibrotic trait of endometriosis through examining the alterations of the S1P signaling pathway. The results show a deep dysregulation of S1P signaling in endometriosis, with S1P synthesis enzymes and receptors playing a crucial role in promoting fibrosis.
FERTILITY AND STERILITY
(2021)
Review
Endocrinology & Metabolism
Alaeddine El Jamal, Carole Bougault, Saida Mebarek, David Magne, Olivier Cuvillier, Leyre Brizuel
Review
Biochemistry & Molecular Biology
Audrey Carriere, Damien Lagarde, Yannick Jeanson, Jean-Charles Portais, Anne Galinier, Isabelle Ader, Louis Casteilla
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Chen Zhang, Pierre-Yves Fortin, Guillaume Barnoin, Xue Qin, Xing Wang, Alvaro Fernandez Alvarez, Christian Bijani, Marie-Lise Maddelein, Catherine Hemmert, Olivier Cuvillier, Heinz Gornitzka
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Review
Medicine, Research & Experimental
Franck Talmont, Anastassia Hatzoglou, Olivier Cuvillier
M S-MEDECINE SCIENCES
(2020)
Article
Cell Biology
Mathieu Borel, Olivier Cuvillier, David Magne, Saida Mebarek, Leyre Brizuela
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Article
Orthopedics
C. Cherifi, A. Latourte, S. Vettorazzi, J. Tuckermann, S. Provot, H. -K. Ea, A. Ledoux, J. Casas, O. Cuvillier, P. Richette, A. Ostertag, E. Hay, M. Cohen-Solal
Summary: The osteoclast secretome promotes chondrocyte catabolism by increasing expression of Mmp3 and Mmp13 and activating the JNK signaling pathway, leading to matrix degradation. Inhibition of osteoclast-mediated chondrocyte catabolism with JTE013 protects against OA, indicating that osteoclastic S1P contributes to cartilage damage. S1P is identified as a potential therapeutic target in OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Cell Biology
Ph. Kemoun, I. Ader, V. Planat-Benard, C. Dray, N. Fazilleau, P. Monsarrat, B. Cousin, J. Paupert, M. Ousset, A. Lorsignol, I. Raymond-Letron, B. Vellas, P. Valet, T. Kirkwood, J. Beard, L. Penicaud, L. Casteilla
Summary: Research on healthy ageing emphasizes the importance of understanding the balance between stability and instability in the body, guiding the development of new preventive and therapeutic strategies.
AGEING RESEARCH REVIEWS
(2022)
Article
Oncology
Anne Gomez-Brouchet, Claire Illac, Adeline Ledoux, Pierre-Yves Fortin, Sandra de Barros, Clementine Vabre, Fabien Despas, Sophie Peries, Christelle Casaroli, Corinne Bouvier, Sebastien Aubert, Gonzague de Pinieux, Frederique Larousserie, Louise Galmiche, Franck Talmont, Stuart Pitson, Marie-Lise Maddelein, Olivier Cuvillier
Summary: The SphK1/S1P signaling pathway is involved in the regulation of HIF-1 alpha expression in osteosarcoma under hypoxia. Inhibiting SphK1 and S1P(1) receptor may be a potential treatment target for osteosarcoma patients. Overexpression of SphK1 and S1P(1) is related to hypoxia marker GLUT-1 in osteosarcoma.
Article
Geriatrics & Gerontology
Juan Luis Sanchez-Sanchez, Isabelle Ader, Yannick Jeanson, Valerie Planat-Benard, Bruno Vellas, Louis Casteilla, Philipe de Souto-Barreto
Summary: Plasma periostin levels were found to be associated with declines in both physical and cognitive capacities in older adults over a 4-year follow-up.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biology
Anne-Claire Godet, Emilie Roussel, Florian David, Fransky Hantelys, Florent Morfoisse, Joffrey Alves, Francoise Pujol, Isabelle Ader, Edouard Bertrand, Odile Burlet-Schiltz, Carine Froment, Anthony K. Henras, Patrice Vitali, Eric Lacazette, Florence Tatin, Barbara Garmy-Susini, Anne-Catherine Prats
Summary: This study reveals the association between the paraspeckle, a stressed-induced nuclear body, and IRES-dependent translation. The long non-coding RNA Neat1 is identified as a key translational regulator, active on IRESs of (lymph)angiogenic and cardioprotective factor mRNAs. Paraspeckle proteins, including p54(nrb) and PSPC1, as well as nucleolin and RPS2, are found to be ITAFs for IRES subgroups. These findings highlight the importance of IRES-dependent translation during stress response.
Review
Geriatrics & Gerontology
I. Ader, L. Penicaud, S. Andrieu, J. R. Beard, N. Davezac, C. Dray, N. Fazilleau, P. Gourdy, S. Guyonnet, R. Liblau, A. Parini, P. Payoux, C. Rampon, I. Raymond-Letron, Y. Rolland, P. de Souto Barreto, P. Valet, N. Vergnolle, F. Sierra, B. Vellas, Louis Casteilla
Summary: The search for solutions to optimize healthy aging and increase health span is a major challenge facing society. The World Health Organization now prioritizes a novel healthcare model based on integration and a shift in research and care towards maintaining optimal functional levels. However, there is a lack of an integrative global strategy that combines longitudinal and experimental cohorts with an innovative understanding of physiological functioning.
JOURNAL OF FRAILTY & AGING
(2021)
Article
Geriatrics & Gerontology
Y. Santin, S. Lopez, I Ader, S. Andrieu, N. Blanchard, A. Carriere, L. Casteilla, B. Cousin, N. Davezac, P. De Souto Barreto, C. Dray, N. Fazilleau, D. Gonzalez-Dunia, P. Gourdy, S. Guyonnet, N. Jabrane-Ferrat, O. Kunduzova, F. Lezoualc'h, R. Liblau, L. O. Martinez, C. Moro, P. Payoux, L. Penicaud, V Planat-Benard, C. Rampon, Y. Rolland, J-P Schanstra, F. Sierra, P. Valet, A. Varin, N. Vergnolle, B. Vellas, J. Vina, B. P. Guiard, A. Parini
Summary: Aging is a major risk factor for chronic diseases, and efforts are now focused on promoting healthy aging by identifying early biological markers associated with functional status. The INSPIRE program aims to discover mechanisms of accelerated aging and predict frailty and pathological aging using a cohort of SWISS mice. This comprehensive study will provide valuable insights into the role of dietary and exercise interventions in influencing the rate of biological aging and identifying targets for healthy aging promotion.
JOURNAL OF FRAILTY & AGING
(2021)
Article
Geriatrics & Gerontology
S. Guyonnet, Y. Rolland, C. Takeda, P-J Ousset, I Ader, N. Davezac, C. Dray, N. Fazilleau, P. Gourdy, R. Liblau, A. Parini, P. Payoux, L. Penicaud, C. Rampon, P. Valet, N. Vergnolle, S. Andrieu, P. De Souto Barreto, L. Casteilla, B. Vellas
Summary: The INSPIRE initiative aims to establish a research program focusing on the biological mechanisms of aging and healthy aging, from animal models to humans and the healthcare system. The INSPIRE-T cohort gathers diverse data from individuals of different ages and functional capacities, with the goal of identifying markers of aging and age-related diseases for potential therapeutic targeting.
JOURNAL OF FRAILTY & AGING
(2021)
Article
Geriatrics & Gerontology
P. De Souto Barreto, S. Guyonnet, I Ader, S. Andrieu, L. Casteilla, N. Davezac, C. Dray, N. Fazilleau, P. Gourdy, R. Liblau, A. Parini, P. Payoux, L. Penicaud, C. Rampon, Y. Rolland, P. Valets, N. Vergnolle, B. Vellas
Summary: Aging is a key risk factor for chronic diseases and functional decline, and understanding the interplay between biological aging, disease biology, and a function-centered care approach is crucial for preventive strategies. The INSPIRE research program aims to explore how manipulation of biological aging and implementation of function-centered care pathways can contribute to healthy aging trajectories.
JOURNAL OF FRAILTY & AGING
(2021)
Review
Clinical Neurology
Florent Guerville, P. De Souto Barreto, I. Ader, S. Andrieu, L. Casteilla, C. Dray, N. Fazilleau, S. Guyonnet, D. Langin, R. Liblau, A. Parini, P. Valet, N. Vergnolle, Y. Rolland, B. Vellas
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2020)