Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect

Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts

(2020) Long Shuang Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure

(2020) Fernando M Reis et al.   HUMAN REPRODUCTION UPDATE

Sphingosine 1-phosphate receptors are dysregulated in endometriosis: possible implication in transforming growth factor β–induced fibrosis

(2020) Caterina Bernacchioni et al.   FERTILITY AND STERILITY

The Role of S1P and the Related Signaling Pathway in the Development of Tissue Fibrosis

(2019) Erjin Wang et al.   Frontiers in Pharmacology

Emergence of membrane sphingolipids as a potential therapeutic target

(2019) Sunil Kumar Sahu et al.   BIOCHIMIE

Sphingosine 1-phosphate-mediated activation of ezrin-radixin-moesin proteins contributes to cytoskeletal remodeling and changes of membrane properties in epithelial otic vesicle progenitors

(2019) Francesca Cencetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Advanced 3D Imaging of Uterine Leiomyoma’s Morphology by Propagation-based Phase-Contrast Microtomography

(2019) Alessandra Giuliani et al.   Scientific Reports

Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

(2019) Andreane Cartier et al.   SCIENCE

Bradykinin mediates myogenic differentiation in murine myoblasts through the involvement of SK1/Spns2/S1P 2 axis

(2018) Gennaro Bruno et al.   CELLULAR SIGNALLING

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

(2018) Olivier Blanchard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysophosphatidic Acid Signaling Axis Mediates Ceramide 1-Phosphate-Induced Proliferation of C2C12 Myoblasts

(2018) Caterina Bernacchioni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics

(2017) Md Soriful Islam et al.   HUMAN REPRODUCTION UPDATE

NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells

(2017) Caterina Bernacchioni et al.   Molecular Oncology

Activin A in Inflammation, Tissue Repair, and Fibrosis: Possible Role as Inflammatory and Fibrotic Mediator of Uterine Fibroid Development and Growth

(2017) Olga Protic et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study

(2017) Katrin G. Schmidt et al.   Frontiers in Immunology

Targeting sphingosine kinase 1 localization as novel target for ovarian cancer therapy

(2017) Caterina Bernacchioni et al.   Translational Cancer Research

Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6

(2017) Sei-ichiro Ohkura et al.   PLoS One

Hormones and pathogenesis of uterine fibroids

(2016) Fernando M. Reis et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Growth factors and pathogenesis

(2016) Md Soriful Islam et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Growth trend of small uterine fibroids and human chorionic gonadotropin serum levels in early pregnancy: an observational study

(2016) Andrea Ciavattini et al.   FERTILITY AND STERILITY

Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN- γ

(2016) Amandeep Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human

(2016) Masaya Sato et al.   Scientific Reports

Possible involvement of inflammatory/reparative processes in the development of uterine fibroids

(2015) Olga Protic et al.   CELL AND TISSUE RESEARCH

Expression Levels of Myostatin and Matrix Metalloproteinase 14 mRNAs in Uterine Leiomyoma are Correlated With Dysmenorrhea

(2015) Anastasia Tsigkou et al.   Reproductive Sciences

Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells

(2014) Md Soriful Islam et al.   FERTILITY AND STERILITY

Role of Activin-A and Myostatin and Their Signaling Pathway in Human Myometrial and Leiomyoma Cell Function

(2014) Md Soriful Islam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Number and size of uterine fibroids and obstetric outcomes

(2014) Andrea Ciavattini et al.   Journal of Maternal-Fetal & Neonatal Medicine

Ulipristal Acetate Modulates the Expression and Functions of Activin A in Leiomyoma Cells

(2014) Pasquapina Ciarmela et al.   Reproductive Sciences

TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation

(2013) Francesca Cencetti et al.   FASEB JOURNAL

Complex networks of multiple factors in the pathogenesis of uterine leiomyoma

(2013) Md Soriful Islam et al.   FERTILITY AND STERILITY

Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis

(2013) Le Yang et al.   JOURNAL OF HEPATOLOGY

Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology

(2013) Chiara Donati et al.   Frontiers in Physiology

Stain-Free technology as a normalization tool in Western blot analysis

(2012) Anne Gürtler et al.   ANALYTICAL BIOCHEMISTRY

New insights into the role of sphingosine 1-phosphate and lysophosphatidic acid in the regulation of skeletal muscle cell biology

(2012) Chiara Donati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium

(2011) Zahra Tanfin et al.   CELLULAR SIGNALLING

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition

(2011) Javier Milara et al.   THORAX

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Activin-A and Myostatin Response and Steroid Regulation in Human Myometrium: Disruption of Their Signalling in Uterine Fibroid

(2010) Pasquapina Ciarmela et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis

(2010) Francesca Cencetti et al.   MOLECULAR BIOLOGY OF THE CELL

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Proinflammatory and Profibrotic Mediators: Principal Effectors of Leiomyoma Development as a Fibrotic Disorder

(2010) Nasser Chegini   SEMINARS IN REPRODUCTIVE MEDICINE

Why Leiomyomas Are Called Fibroids: The Central Role of Extracellular Matrix in Symptomatic Women

(2010) Minnie Malik et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

(2009) Kate E. Jarman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model

(2009) Minglun Li et al.   Radiation Oncology

TGFβ protects mesoangioblasts from apoptosis via sphingosine kinase-1 regulation

(2008) Chiara Donati et al.   CELLULAR SIGNALLING

Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells

(2008) Minnie Malik et al.   CLINICAL ENDOCRINOLOGY

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2

(2008) Hitoshi Ikeda et al.   JOURNAL OF LIPID RESEARCH

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols