Humanized Mouse Models for Transplant Immunology

Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm

(2015) Gregory L. Szot et al.   Cell Stem Cell

T-cell alloreactivity and transplantation outcome

(2015) Heleen van den Heuvel et al.   Current Opinion in Organ Transplantation

CD8-positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice

(2015) S.T. Laing et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2–Producing Transgenic NOG Mouse

(2015) Ikumi Katano et al.   JOURNAL OF IMMUNOLOGY

An Effective Approach to Prevent Immune Rejection of Human ESC-Derived Allografts

(2014) Zhili Rong et al.   Cell Stem Cell

Treating diabetes with islet transplantation: Lessons from the past decade in Lille

(2014) M.-C. Vantyghem et al.   DIABETES & METABOLISM

Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts

(2014) H. Kalscheuer et al.   JOURNAL OF IMMUNOLOGY

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Ex Vivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34+ Stem Cells-Reconstituted NOD-scid IL2rγnull Mice

(2014) Fang Xiao et al.   PLoS One

Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance

(2014) Patricia .E de Almeida et al.   Nature Communications

Humanized mouse models in transplantation research

(2014) Marieke Hogenes et al.   Transplantation Reviews

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

(2013) Anthony Rongvaux et al.   Annual Review of Immunology

BLT-humanized C57BL/6 Rag2-/- c-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection

(2013) K. J. Lavender et al.   BLOOD

HLA Class I Antibodies Trigger Increased Adherence of Monocytes to Endothelial Cells by Eliciting an Increase in Endothelial P-Selectin and, Depending on Subclass, by Engaging Fc Rs

(2013) N. M. Valenzuela et al.   JOURNAL OF IMMUNOLOGY

Overcoming Current Limitations in Humanized Mouse Research

(2013) Michael A. Brehm et al.   JOURNAL OF INFECTIOUS DISEASES

Ischemia-Reperfusion Injury Accelerates Human Antibody-Mediated Transplant Vasculopathy

(2013) Ryoichi Goto et al.   TRANSPLANTATION

Ex Vivo Expanded Human Regulatory T Cells Can Prolong Survival of a Human Islet Allograft in a Humanized Mouse Model

(2013) Douglas C. Wu et al.   TRANSPLANTATION

Blockade of P-Selectin Is Sufficient to Reduce MHC I Antibody-Elicited Monocyte RecruitmentIn VitroandIn Vivo

(2012) N. M. Valenzuela et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human allograft rejection in humanized mice: a historical perspective

(2012) Michael A Brehm et al.   Cellular & Molecular Immunology

Current advances in humanized mouse models

(2012) Ryoji Ito et al.   Cellular & Molecular Immunology

Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice

(2012) Shounan Yi et al.   DIABETES

A humanized mouse model to study human immune response in xenotransplantation

(2012) Ming Ji et al.   Hepatobiliary & Pancreatic Diseases International

Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/ cnull mouse

(2012) M. Suzuki et al.   INTERNATIONAL IMMUNOLOGY

Humanized Mouse Model of Skin Inflammation Is Characterized by Disturbed Keratinocyte Differentiation and Influx of IL-17A Producing T Cells

(2012) Vivian L. de Oliveira et al.   PLoS One

Transforming Growth Factor Beta Expression by Human Vascular Cells Inhibits Interferon Gamma Production and Arterial Media Injury by Alloreactive Memory T Cells

(2011) A. H. Lebastchi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Reperfusion Injury Intensifies the Adaptive Human T Cell Alloresponse in a Human-Mouse Chimeric Artery Model

(2011) Tai Yi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutralizing IL-6 Reduces Human Arterial Allograft Rejection by Allowing Emergence of CD161+ CD4+ Regulatory T Cells

(2011) B. Fogal et al.   JOURNAL OF IMMUNOLOGY

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

(2011) Rebecca Danner et al.   PLoS One

Allo-HLA reactivity of virus-specific memory T cells is common

(2010) A. L. Amir et al.   BLOOD

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2r null Ins2Akita Mice

(2010) M. A. Brehm et al.   DIABETES

In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells

(2010) Satish N Nadig et al.   NATURE MEDICINE

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD-scid IL2rγnull Mouse Model of Human Skin Transplantation and Allograft Rejection

(2010) Waldemar J. Racki et al.   TRANSPLANTATION

Ex Vivo–Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model

(2010) Fadi Issa et al.   TRANSPLANTATION

Contribution of Naïve and Memory T-Cell Populations to the Human Alloimmune Response

(2009) C. Macedo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Humanized Mice for the Study of Type 1 Diabetes and Beta Cell Function

(2009) Marie King et al.   Annals of the New York Academy of Sciences

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Priming of protective T cell responses against virus-induced tumors in mice with human immune system components

(2009) Till Strowig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alloreactivity but Failure to Reject Human Islet Transplants by Humanized Balb/c/Rag2−/−gc−/−Mice

(2009) S. Jacobson et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury

(2009) Nancy C. Kirkiles-Smith et al.   TRANSPLANTATION

Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection

(2008) Deepak A. Rao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Possible Pathogenic Role of Th17 Cells for Atopic Dermatitis

(2008) Chizuko Koga et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

(2008) Michelle A. Lowes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interleukin-1β: a bridge between inflammation and excitotoxicity?

(2008) Birgit Fogal et al.   JOURNAL OF NEUROCHEMISTRY

Human BLyS Facilitates Engraftment of Human PBL Derived B Cells in Immunodeficient Mice

(2008) Madelyn R. Schmidt et al.   PLoS One

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene

(2007) Marie King et al.   CLINICAL IMMUNOLOGY