The Voltage-Gated Calcium Channel Functions as the Molecular Switch of Synaptic Transmission

Voltage-Driven Ca2+ Binding at the L-Type Ca2+ Channel Triggers Cardiac Excitation–Contraction Coupling Prior to Ca2+ Influx

(2012) Liron S. Gez et al.   BIOCHEMISTRY

Phosphatidylinositol 4,5-Bisphosphate Alters Synaptotagmin 1 Membrane Docking and Drives Opposing Bilayers Closer Together

(2011) Weiwei Kuo et al.   BIOCHEMISTRY

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

Mechanism of Spontaneous Activity in Afferent Neurons of the Zebrafish Lateral-Line Organ

(2011) J. G. Trapani et al.   JOURNAL OF NEUROSCIENCE

Membrane Penetration by Synaptotagmin Is Required for Coupling Calcium Binding to Vesicle Fusion In Vivo

(2011) B. E. Paddock et al.   JOURNAL OF NEUROSCIENCE

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation

(2011) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

v-SNARE Composition Distinguishes Synaptic Vesicle Pools

(2011) Zhaolin Hua et al.   NEURON

Membrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)- dependent potentiation of catecholamine release

(2011) M. Marom et al.   NEUROSCIENCE

A small pool of vesicles maintains synaptic activity in vivo

(2011) A. Denker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

(2011) M. Kyoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Ca2+ sensors in secretion: teammates, competitors or autocrats?

(2011) Alexander M. Walter et al.   TRENDS IN NEUROSCIENCES

Synaptic Vesicle Exocytosis

(2011) T. C. Sudhof et al.   Cold Spring Harbor Perspectives in Biology

Calcium Control of Neurotransmitter Release

(2011) T. C. Sudhof   Cold Spring Harbor Perspectives in Biology

Simulations of calcium channel block by trivalent cations: Gd 3+ competes with permeant ions for the selectivity filter

(2010) Attila Malasics et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Signaling role of the voltage-gated calcium channel as the molecular on/off-switch of secretion

(2010) Daphne Atlas   CELLULAR SIGNALLING

CaV2.1 (P/Q channel) interaction with synaptic proteins is essential for depolarization-evoked release

(2010) Moshe Cohen-Kutner et al.   Channels

Conformational Changes Induced in Voltage-gated Calcium Channel Cav1.2 by BayK 8644 or FPL64176 Modify the Kinetics of Secretion Independently of Ca2+Influx

(2010) Merav Marom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute Dynamin Inhibition Dissects Synaptic Vesicle Recycling Pathways That Drive Spontaneous and Evoked Neurotransmission

(2010) C. Chung et al.   JOURNAL OF NEUROSCIENCE

A common origin of synaptic vesicles undergoing evoked and spontaneous fusion

(2010) Yunfeng Hua et al.   NATURE NEUROSCIENCE

The same synaptic vesicles drive active and spontaneous release

(2010) Benjamin G Wilhelm et al.   NATURE NEUROSCIENCE

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity

(2010) Mingshan Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin Clamps Asynchronous Release by Blocking a Secondary Ca2+ Sensor via Its Accessory α Helix

(2010) Xiaofei Yang et al.   NEURON

Doc2b Is a High-Affinity Ca2+ Sensor for Spontaneous Neurotransmitter Release

(2010) A. J. Groffen et al.   SCIENCE

Protein-driven membrane stresses in fusion and fission

(2010) Michael M. Kozlov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion

(2009) Enfu Hui et al.   CELL

The Ca2+Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate

(2009) Anand Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Activation and Membrane Potential Changes Modulate the Frequency of Spontaneous Elementary Ca2+ Release Events in the Dendrites of Pyramidal Neurons

(2009) S. Manita et al.   JOURNAL OF NEUROSCIENCE

A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse

(2009) Naila Ben Fredj et al.   NATURE NEUROSCIENCE

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

(2009) Jun Xu et al.   NATURE NEUROSCIENCE

Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

(2009) A. Maximov et al.   SCIENCE

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

The Voltage-Gated Ca2+Channel Is the Ca2+Sensor Protein of Secretion†

(2008) Yamit Hagalili et al.   BIOCHEMISTRY

Membrane traffic in the secretory pathway

(2008) J. Malsam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ca2+-Dependent, Phospholipid-Binding Residues of Synaptotagmin Are Critical for Excitation-Secretion Coupling In Vivo

(2008) B. E. Paddock et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of membrane fusion: disparate players and common principles

(2008) Sascha Martens et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

(2008) Michael C Chicka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY