The N-end rule pathway: emerging functions and molecular principles of substrate recognition

Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization

(2011) F.-Nora Vögtle et al.   MOLECULAR BIOLOGY OF THE CELL

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

Partners in Crime: Ubiquitin-Mediated Degradation and Autophagy

(2011) S. M. Sriram et al.   Science Signaling

Towards a Functional Understanding of Protein N-Terminal Acetylation

(2011) Thomas Arnesen   PLOS BIOLOGY

N-Terminal Acetylation Inhibits Protein Targeting to the Endoplasmic Reticulum

(2011) Gabriella M. A. Forte et al.   PLOS BIOLOGY

The arginylation-dependent association of calreticulin with stress granules is regulated by calcium

(2010) Marcos A. Carpio et al.   BIOCHEMICAL JOURNAL

SnapShot: Key Numbers in Biology

(2010) Uri Moran et al.   CELL

The bacterial N-end rule pathway: expect the unexpected

(2010) D. A. Dougan et al.   MOLECULAR MICROBIOLOGY

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases

(2010) Woo Suk Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of substrate recognition and specificity in the N-end rule pathway

(2010) Edna Matta-Camacho et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The molecular principles of N-end rule recognition

(2010) Shashikanth M Sriram et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

(2010) J. Y. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Arginylation of Actin Isoforms Is Regulated by Coding Sequence-Dependent Degradation

(2010) F. Zhang et al.   SCIENCE

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

The plant N-end rule pathway: structure and functions

(2010) Emmanuelle Graciet et al.   TRENDS IN PLANT SCIENCE

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

(2009) F.-Nora Vögtle et al.   CELL

Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin- Dependent N-End Rule Pathway

(2009) Shashikanth M. Sriram et al.   CHEMISTRY & BIOLOGY

Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli

(2009) Robert L Ninnis et al.   EMBO JOURNAL

Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS

(2009) Verena J Schuenemann et al.   EMBO REPORTS

Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway

(2009) Haiqing Wang et al.   MOLECULAR CELL

ClpS is the recognition component forEscherichia colisubstrates of the N-end rule degradation pathway

(2009) Ronny Schmidt et al.   MOLECULAR MICROBIOLOGY

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

(2009) C.-S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of substrate selection by the N-end rule adaptor protein ClpS

(2009) G. Roman-Hernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development

(2009) E. Graciet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1

(2008) Frederik Eisele et al.   FEBS LETTERS

Tuning the Strength of a Bacterial N-end Rule Degradation Signal

(2008) Kevin H. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Substrate Recognition Domains of the N-end Rule Pathway

(2008) Takafumi Tasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway

(2008) Zanxian Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HECT Domain of TRIP12 Ubiquitinates Substrates of the Ubiquitin Fusion Degradation Pathway

(2008) Yoon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Basis of N-End Rule Recognition

(2008) Kevin H. Wang et al.   MOLECULAR CELL

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The N-end rule at atomic resolution

(2008) Alexander Varshavsky   NATURE STRUCTURAL & MOLECULAR BIOLOGY