Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis

Pfizer's first-in-class JAK inhibitor pricey for rheumatoid arthritis market

(2013) Ken Garber   NATURE BIOTECHNOLOGY

Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells

(2012) Ji Hyeon Ju et al.   ARTHRITIS AND RHEUMATISM

Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis

(2012) Wei Gao et al.   ARTHRITIS AND RHEUMATISM

Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription

(2012) Kimberlee S. Mix et al.   ARTHRITIS AND RHEUMATISM

Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation

(2012) Jan-Marcus Daniel et al.   BASIC RESEARCH IN CARDIOLOGY

The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon

(2011) Sanna Rosengren et al.   ANNALS OF THE RHEUMATIC DISEASES

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

IL-1  and TNF -initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis

(2011) T. Mori et al.   INTERNATIONAL IMMUNOLOGY

Hypoxia-inducible Factor-1α Enhances Haptoglobin Gene Expression by Improving Binding of STAT3 to the Promoter

(2011) Mi-Kyung Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

(2011) Kamran Ghoreschi et al.   JOURNAL OF IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of blood vessel sprouting

(2011) John C. Chappell et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate

(2011) Yoshiya Tanaka et al.   ARTHRITIS CARE & RESEARCH

Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures

(2011) Sinéad Nic An Ultaigh et al.   ARTHRITIS RESEARCH & THERAPY

A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis

(2011) Kristine L Stump et al.   ARTHRITIS RESEARCH & THERAPY

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

Angiogenesis and blood vessel stability in inflammatory arthritis

(2010) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-γ

(2010) Svitlana Demyanets et al.   BASIC RESEARCH IN CARDIOLOGY

STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma

(2010) A Horiguchi et al.   BRITISH JOURNAL OF CANCER

STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation

(2010) Rosanna Sestito et al.   FASEB JOURNAL

IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3

(2010) C. J. Greenhill et al.   JOURNAL OF IMMUNOLOGY

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

(2010) Matthew A Bill et al.   Molecular Cancer

Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial

(2009) J H Coombs et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia Activates NF-κB–Dependent Gene Expression Through the Canonical Signaling Pathway

(2009) Kathryn M. Oliver et al.   ANTIOXIDANTS & REDOX SIGNALING

Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: An implication for the pathogenesis of arthritis

(2009) Sang-Heng Kok et al.   ARTHRITIS AND RHEUMATISM

Jagged Gives Endothelial Tip Cells an Edge

(2009) Steven Suchting et al.   CELL

STAT3 as a Central Regulator of Tumor Metastases

(2009) Eswaran Devarajan et al.   CURRENT MOLECULAR MEDICINE

STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination

(2009) Joo Eun Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Jagged1 regulates the activation of astrocytes via modulation of NFκB and JAK/STAT/SOCS pathways

(2009) Eleonora Morga et al.   GLIA

Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway

(2009) J. H. Lee et al.   MOLECULAR CANCER RESEARCH

Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis

(2009) Mohammed A Akhavani et al.   ARTHRITIS RESEARCH & THERAPY

A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells

(2008) Ling-Yuan Kong et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

WP1066, a Novel JAK2 Inhibitor, Suppresses Proliferation and Induces Apoptosis in Erythroid Human Cells Carrying the JAK2 V617F Mutation

(2008) S. Verstovsek et al.   CLINICAL CANCER RESEARCH

A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

(2008) L.-Y. Kong et al.   CLINICAL CANCER RESEARCH

Synovial Hypoxia as a Cause of Tendon Rupture in Rheumatoid Arthritis

(2008) Branavan Sivakumar et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

STAT3: A critical transcription activator in angiogenesis

(2007) Zhong Chen et al.   MEDICINAL RESEARCH REVIEWS