Negative CD4 + TIM-3 Signaling Confers Resistance Against Cold Preservation Damage in Mouse Liver Transplantation

TIMgenes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

(2015) Gordon J. Freeman et al.   IMMUNOLOGICAL REVIEWS

Tim-3 signaling pathway as a novel negative mediator in lipopolysaccharide-induced endotoxic shock

(2014) Feng Wang et al.   HUMAN IMMUNOLOGY

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease

(2013) Z.-H. Tang et al.   JOURNAL OF IMMUNOLOGY

Galectin-9-Mediated Protection from Allo-Specific T Cells as a Mechanism of Immune Privilege of Corneal Allografts

(2013) Machiko Shimmura-Tomita et al.   PLoS One

Tim-3: An Activation Marker and Activation Limiter of Innate Immune Cells

(2013) Gencheng Han et al.   Frontiers in Immunology

Targeting TIM-1 on CD4 T Cells Depresses Macrophage Activation and Overcomes Ischemia-Reperfusion Injury in Mouse Orthotopic Liver Transplantation

(2012) Y. Zhang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection

(2012) S. Elahi et al.   BLOOD

Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+T cells

(2012) Sandra Pommey et al.   HEPATOLOGY

Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs

(2012) Shipra Gupta et al.   JOURNAL OF CLINICAL INVESTIGATION

Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

(2012) Yuan Zhai et al.   Nature Reviews Gastroenterology & Hepatology

The Role of Coinhibitory Signaling Pathways in Transplantation and Tolerance

(2012) Martina M. McGrath et al.   Frontiers in Immunology

The Emerging Role of the TIM Molecules in Transplantation

(2011) M. Y. Yeung et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Major Challenges Limiting Liver Transplantation in the United States

(2011) J. A. Wertheim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Liver Ischemia and Reperfusion Injury: New Insights into Mechanisms of Innate-Adaptive Immune-Mediated Tissue Inflammation

(2011) Y. Zhai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

The TIM-1:TIM-4 Pathway Enhances Renal Ischemia-Reperfusion Injury

(2011) S. Rong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

T-Cell Immunoglobulin Mucin-3 Determines Severity of Liver Ischemia/Reperfusion Injury in Mice in a TLR4-Dependent Manner

(2010) Yoichiro Uchida et al.   GASTROENTEROLOGY

Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury

(2010) Haofeng Ji et al.   HEPATOLOGY

TIM-3: A Novel Regulatory Molecule of Alloimmune Activation

(2010) O. Boenisch et al.   JOURNAL OF IMMUNOLOGY

Distinct contributions of CD4+ T cell subsets in hepatic ischemia/reperfusion injury

(2009) Satoshi Kuboki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury

(2009) Xiuda Shen et al.   HEPATOLOGY

The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse

(2009) Yoichiro Uchida et al.   HEPATOLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Galectin-9 Significantly Prolongs the Survival of Fully Mismatched Cardiac Allografts in Mice

(2009) Wentao He et al.   TRANSPLANTATION