Generation of β cells from human pluripotent stem cells: Are we there yet?

Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs

(2013) T. Guo et al.   DIABETES

Development of the Human Pancreas From Foregut to Endocrine Commitment

(2013) R. E. Jennings et al.   DIABETES

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

The Role of CXCL12-CXCR4 Signaling Pathway in Pancreatic Development

(2013) Keiichi Katsumoto et al.   Theranostics

Retinoic acid signalling during development

(2012) M. Rhinn et al.   DEVELOPMENT

EphB3 marks delaminating endocrine progenitor cells in the developing pancreas

(2012) Alethia Villasenor et al.   DEVELOPMENTAL DYNAMICS

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Differentiating neural crest stem cells induce proliferation of cultured rodent islet beta cells

(2012) G. Grouwels et al.   DIABETOLOGIA

A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

(2012) Thomas C. Schulz et al.   PLoS One

Molecular pathways controlling pancreas induction

(2012) Kyle W. McCracken et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate

(2011) K. Katsumoto et al.   DEVELOPMENT

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development

(2011) Mathieu Gouzi et al.   DEVELOPMENTAL DYNAMICS

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3

(2011) O. Rubio-Cabezas et al.   DIABETES

INS GFP/w human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells

(2011) S. J. Micallef et al.   DIABETOLOGIA

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

(2011) C. L. Basford et al.   DIABETOLOGIA

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3

(2011) H. K. Bone et al.   JOURNAL OF CELL SCIENCE

Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

(2011) Xiaofang Xu et al.   MECHANISMS OF DEVELOPMENT

Transgenic Overexpression of the Transcription Factor Nkx6.1 in β-Cells of Mice Does Not Increase β-Cell Proliferation, β-Cell Mass, or Improve Glucose Clearance

(2011) Ashleigh E. Schaffer et al.   MOLECULAR ENDOCRINOLOGY

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells

(2011) Michael D Green et al.   NATURE BIOTECHNOLOGY

Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters

(2011) Dennis Van Hoof et al.   Stem Cell Research

Activin and BMP4 Synergistically Promote Formation of Definitive Endoderm in Human Embryonic Stem Cells

(2011) Adrian K. K. Teo et al.   STEM CELLS

Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation

(2010) Jennifer L. Plank et al.   DEVELOPMENTAL BIOLOGY

MafA and MafB Regulate Genes Critical to  -Cells in a Unique Temporal Manner

(2010) I. Artner et al.   DIABETES

Production of Functional Glucagon-Secreting  -Cells From Human Embryonic Stem Cells

(2010) A. Rezania et al.   DIABETES

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Differentiating Embryonic Stem Cells Pass through ‘Temporal Windows’ That Mark Responsiveness to Exogenous and Paracrine Mesendoderm Inducing Signals

(2010) Steven A. Jackson et al.   PLoS One

The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells

(2009) Gen-hong Mao et al.   BIOMATERIALS

Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells

(2009) Donghui Zhang et al.   CELL RESEARCH

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells

(2009) Malgorzata Borowiak et al.   Cell Stem Cell

Endocrine Cell Clustering During Human Pancreas Development

(2009) Jongmin Jeon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells

(2008) A. Eshpeter et al.   CELL PROLIFERATION

Signals from the neural crest regulate beta-cell mass in the pancreas

(2008) N. Nekrep et al.   DEVELOPMENT

Biphasic Ngn3 expression in the developing pancreas

(2008) Alethia Villasenor et al.   DEVELOPMENTAL DYNAMICS

Transcription factor expression in the developing human fetal endocrine pancreas

(2008) B. M. Lyttle et al.   DIABETOLOGIA

Stimulation of Human and Rat Islet  -Cell Proliferation with Retention of Function by the Homeodomain Transcription Factor Nkx6.1

(2008) J. C. Schisler et al.   MOLECULAR AND CELLULAR BIOLOGY

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY