Molecular targets in heart failure gene therapy: current controversies and translational perspectives

Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure

(2011) Elizabeth L. Lockamy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphatase-1 inhibitor-1 in physiological and pathological  -adrenoceptor signalling

(2011) K. Wittkopper et al.   CARDIOVASCULAR RESEARCH

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

Inhibition of PKCα/β With Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury

(2011) Dennis Ladage et al.   CIRCULATION RESEARCH

The Art of MicroRNA Research

(2011) Eva van Rooij   CIRCULATION RESEARCH

SERCA2a Gene Transfer Decreases Sarcoplasmic Reticulum Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure

(2011) Alexander R. Lyon et al.   Circulation-Arrhythmia and Electrophysiology

Cardiac inotropes: current agents and future directions

(2011) G. Hasenfuss et al.   EUROPEAN HEART JOURNAL

Vstm3 is a member of the CD28 family and an important modulator of T-cell function

(2011) Steven D. Levin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines

(2011) Lawrence T. Bish et al.   HUMAN GENE THERAPY

Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats

(2011) Elie R. Chemaly et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adenylyl Cyclase 6 Improves Calcium Uptake and Left Ventricular Function in Aged Hearts

(2011) Tong Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

S100A1: Another Step Toward Therapeutic Development for Heart Failure⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

(2011) Stephen L. Belmonte et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Rescuing the Failing Heart by Targeted Gene Transfer

(2011) Yoshiaki Kawase et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

S100A1 Genetically Targeted Therapy Reverses Dysfunction of Human Failing Cardiomyocytes

(2011) Henriette Brinks et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

SUMO1-dependent modulation of SERCA2a in heart failure

(2011) Changwon Kho et al.   NATURE

Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

(2011) S. T. Pleger et al.   Science Translational Medicine

Effects of CXCR4 Gene Transfer on Cardiac Function After Ischemia-Reperfusion Injury

(2010) Jiqiu Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Ca 2+ Cycling and New Therapeutic Approaches for Heart Failure

(2010) Anne-Marie Lompré et al.   CIRCULATION

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

β2-Adrenergic Receptor Signaling in the Cardiac Myocyte is Modulated by Interactions With CXCR4

(2010) Thomas J LaRocca et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cardiac gene therapy with SERCA2a: From bench to bedside

(2010) Judith K. Gwathmey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SDF-1α as a therapeutic stem cell homing factor in myocardial infarction

(2010) Santhosh K. Ghadge et al.   PHARMACOLOGY & THERAPEUTICS

Adenylyl cyclase type 5 protein expression during cardiac development and stress

(2009) Che-Lin Hu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

β1-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: Differences in transgene localization and intracellular signaling

(2009) Mei Hua Gao et al.   CELLULAR SIGNALLING

Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy

(2009) Lennart Suckau et al.   CIRCULATION

Adenylyl Cyclase Type 5 Disruption Prolongs Longevity and Protects the Heart Against Stress

(2009) Stephen F. Vatner et al.   CIRCULATION JOURNAL

Sarcoplasmic reticulum Ca2+ATPase as a therapeutic target for heart failure

(2009) Larissa Lipskaia et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID Trial), a First-in-Human Phase 1/2 Clinical Trial

(2009) Brian E. Jaski et al.   JOURNAL OF CARDIAC FAILURE

Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca 2+ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion

(2008) Fabrice Prunier et al.   CIRCULATION

Gene Therapy in Heart Failure

(2008) Leif Erik Vinge et al.   CIRCULATION RESEARCH

Adenylyl Cyclase Type VI Increases Akt Activity and Phospholamban Phosphorylation in Cardiac Myocytes

(2008) Mei Hua Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene therapy: targeting the myocardium

(2007) A R Lyon et al.   HEART