Potential and Emerging Treatment Options for Ebola Virus Disease

Caring for Critically Ill Patients with Ebola Virus Disease. Perspectives from West Africa

(2014) Robert A. Fowler et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety and Pharmacokinetic Profiles of Phosphorodiamidate Morpholino Oligomers with Activity against Ebola Virus and Marburg Virus: Results of Two Single-Ascending-Dose Studies

(2014) Alison E. Heald et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

(2014) Lisa Oestereich et al.   ANTIVIRAL RESEARCH

Post-exposure efficacy of Oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model

(2014) Sophie J. Smither et al.   ANTIVIRAL RESEARCH

Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1

(2014) Wei Xu et al.   Cell Host & Microbe

Effect of the use of low and high potency statins and sepsis outcomes

(2014) Shu-Yu Ou et al.   INTENSIVE CARE MEDICINE

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

(2014) Gerrit Gehring et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Practical Treatment for Patients With Ebola Virus Disease

(2014) D. S. Fedson   JOURNAL OF INFECTIOUS DISEASES

Experimental Ebola drugs enter the limelight

(2014) Asher Mullard   LANCET

Ebola: a call for blood transfusion strategy in sub-Saharan Africa

(2014) Thierry Burnouf et al.   LANCET

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

(2014) Xiangguo Qiu et al.   NATURE

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

(2014) Travis K. Warren et al.   NATURE

Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge

(2014) Daphne A Stanley et al.   NATURE MEDICINE

Ebola Virus Disease in West Africa — The First 9 Months of the Epidemic and Forward Projections

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Ebola Vaccine — An Urgent International Priority

(2014) Rupa Kanapathipillai et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Effect of Statins on Mortality in Septic Patients: A Meta-Analysis of Randomized Controlled Trials

(2014) Laura Pasin et al.   PLoS One

First Ebola treatment is approved by WHO

(2014) A. Gulland   BMJ-British Medical Journal

FDA allows second experimental drug to be tested in Ebola patients

(2014) M. McCarthy   BMJ-British Medical Journal

US signs contract with ZMapp maker to accelerate development of the Ebola drug

(2014) M. McCarthy   BMJ-British Medical Journal

Mechanism of Action of T-705 Ribosyl Triphosphate against Influenza Virus RNA Polymerase

(2013) Hidehiro Sangawa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral Efficacy of Favipiravir against Two Prominent Etiological Agents of Hantavirus Pulmonary Syndrome

(2013) David Safronetz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Persistent Immune Responses after Ebola Virus Infection

(2013) Ariel Sobarzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

(2013) Peter B. Madrid et al.   PLoS One

Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail

(2013) J. Pettitt et al.   Science Translational Medicine

FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection

(2013) L. M. Johansen et al.   Science Translational Medicine

Anticoagulant effects of statins and their clinical implications

(2013) Kathleen Brummel-Ziedins et al.   THROMBOSIS AND HAEMOSTASIS

First Pharmacokinetic and Safety Study in Humans of the Novel Lipid Antiviral Conjugate CMX001, a Broad-Spectrum Oral Drug Active against Double-Stranded DNA Viruses

(2012) Wendy Painter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A new player in the puzzle of filovirus entry

(2012) Judith M. White et al.   NATURE REVIEWS MICROBIOLOGY

Lovastatin for adult patients with dengue: protocol for a randomised controlled trial

(2012) James Whitehorn et al.   Trials

Clinical Management of Filovirus-Infected Patients

(2012) Danielle V. Clark et al.   Viruses-Basel

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

(2012) Patrick Iversen et al.   Viruses-Basel

Persistence in darkness of virulent alphaviruses, Ebola virus, and Lassa virus deposited on solid surfaces

(2010) Jose-Luis Sagripanti et al.   ARCHIVES OF VIROLOGY

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

(2010) Thomas W Geisbert et al.   LANCET

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

Development of CMX001 for the Treatment of Poxvirus Infections

(2010) Randall Lanier et al.   Viruses-Basel

A Randomized Controlled Trial of Chloroquine for the Treatment of Dengue in Vietnamese Adults

(2010) Vianney Tricou et al.   PLoS Neglected Tropical Diseases

Antimotility Agents for the Treatment ofClostridium difficileDiarrhea and Colitis

(2009) Hoonmo L. Koo et al.   CLINICAL INFECTIOUS DISEASES

Single-Injection Vaccine Protects Nonhuman Primates against Infection with Marburg Virus and Three Species of Ebola Virus

(2009) T. W. Geisbert et al.   JOURNAL OF VIROLOGY

Mucosal Immunization of Cynomolgus Macaques with the VSVΔG/ZEBOVGP Vaccine Stimulates Strong Ebola GP-Specific Immune Responses

(2009) Xiangguo Qiu et al.   PLoS One

Treatment of Late Stage Disease in a Model of Arenaviral Hemorrhagic Fever: T-705 Efficacy and Reduced Toxicity Suggests an Alternative to Ribavirin

(2008) Brian B. Gowen et al.   PLoS One

On Chikungunya Acute Infection and Chloroquine Treatment

(2008) Xavier De Lamballerie et al.   VECTOR-BORNE AND ZOONOTIC DISEASES