Review
Immunology
Katie Louise Raby, Charalambos Michaeloudes, James Tonkin, Kian Fan Chung, Pankaj Kumar Bhavsar
Summary: The airway epithelium is composed of different types of cells that act as a physical barrier against pathogens. Abnormal epithelial structure and function caused by chronic injury and abnormal repair drive airway diseases such as asthma and COPD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Cherng-Shyang Chang, Yi-Chu Liao, Chih-Ting Huang, Chiao-Mei Lin, Chantal Hoi Yin Cheung, Jhen-Wei Ruan, Wen-Hsuan Yu, Yi-Ting Tsai, I-Jung Lin, Chien-Hsun Huang, Jong-Shian Liou, Ya-Hsien Chou, Hung-Jen Chien, Hsiao-Li Chuang, Hsueh-Fen Juan, Hsuan-Cheng Huang, Hong-Lin Chan, Yu-Chieh Liao, Shiue-Cheng Tang, Yu-Wen Su, Tse-Hua Tan, Andreas J. Baeumler, Cheng-Yuan Kao
Summary: The knockout of Dusp6 enhances baseline colon barrier integrity and ameliorates DSS-induced colonic injury, accompanied by altered glucose metabolism and increased mitochondrial oxygen consumption in Caco-2 cells. Dusp6-knockout mice are more resistant to DSS-induced dysbiosis, and a member of the genus Duncaniella in the gut microbiota confers host protection from injury.
Article
Immunology
Jeremy F. Strain, Sarah A. Cooley, Dimitre Tomov, Anna Boerwinkle, Beau M. Ances
Summary: This study compared T1w/T2w values between virologically well-controlled people with HIV and HIV-negative individuals, and found reduced values in certain brain regions for the HIV group. These reductions were associated with cardiovascular disease risk and age, but not with typical HIV measures. Additionally, the study proposed T1w/T2w as a marker of cortical myelin, providing important insights for future research.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Patricia Schroeder, Marion Rivalan, Sami Zaqout, Christina Krueger, Jutta Schueler, Melissa Long, Andreas Meisel, York Winter, Angela M. Kaindl, Seija Lehnardt
Summary: The absence of MyD88 leads to morphological and cellular changes in the mouse brain, as well as alterations in specific behaviors. The data suggest a pathophysiological significance of MyD88 for mammalian CNS development, structure, and function.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Chemistry, Multidisciplinary
Aseer Intisar, Hyun Young Shin, Woon-Hae Kim, Hyun Gyu Kang, Min Young Kim, Yu Seon Kim, Youngjun Cho, Yun Jeoung Mo, Heejin Lim, Sanghoon Lee, Q. Richard Lu, Yun-Il Lee, Minseok S. Kim
Summary: This study demonstrates that electroceutical treatment with optimal electrical stimulation conditions has the potential to treat CMT disease and restore impaired myelin membrane integrity, providing practical interventions for peripheral demyelinating neuropathies.
Article
Neurosciences
Aldrin K. Y. Yim, Peter L. Wang, John R. Bermingham, Amber Hackett, Amy Strickland, Timothy M. Miller, Cindy Ly, Robi D. Mitra, Jeffrey Milbrandt
Summary: Using single-nuclei RNA sequencing, this study analyzed the diversity of cell types in peripheral nerves and identified a novel myelinating Schwann cell subtype that is depleted in ALS cases. These findings serve as a valuable reference for future studies of nerve biology and disease.
NATURE NEUROSCIENCE
(2022)
Review
Cell Biology
Ece Bayir, Aylin Sendemir
Summary: The blood-brain barrier is a highly selective cellular monolayer unique to the central nervous system microvasculature, mediating communication with the body by regulating the passage of molecules. Recent studies have highlighted the importance of intermediate filaments in the formation and function of cell-cell junctions, particularly vimentin in endothelial cells. Intermediate filaments may have been overlooked as key targets in regulating blood-brain barrier permeability in health and disease.
Article
Multidisciplinary Sciences
Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya
Summary: Glucose-responsive ATP-sensitive potassium channels (K-ATP) play important roles in the peripheral nervous system, affecting neurite outgrowth and nerve conduction velocity.
Article
Cell Biology
Miku Kawaguchi, Naoyuki Kawao, Masafumi Muratani, Yoshimasa Takafuji, Masayoshi Ishida, Yuko Kinoshita, Yuto Takada, Yuya Mizukami, Takashi Ohira, Hiroshi Kaji
Summary: In this study, we identified PMP22 as a novel myokine induced by chronic exercise in mice. We found that PMP22 suppresses osteoclast formation and the osteoblast phenotype in vitro.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Neurosciences
Georgina A. Craig, SangWon Yoo, Tian Y. Du, Junhua Xiao
Summary: Research has shown that myelin deposition in the central nervous system can be influenced by experience, with sensory enrichment increasing myelination and sensory or social deprivation decreasing myelination. Adaptive myelination is considered an essential component of new learning, driving nuanced alterations that ultimately lead to functional responses.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jay Rollins, Tyler Worthington, Allison Dransfield, Jordan Whitney, Jordan Stanford, Emily Hooke, Joseph Hobson, Jacob Wengler, Sandra Hope, Dario Mizrachi
Summary: Cell-adhesion molecules (CAMs) are responsible for various cell interactions. In this study, the expression of CLDN proteins in E. coli is investigated and its consequences are discussed. The iCLASP method is introduced as a high-throughput screening approach for identifying paracellular modulators for CLDN2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
David Djuanda, Bo He, Xiangxia Liu, Shuqia Xu, Yi Zhang, Yangbin Xu, Zhaowei Zhu
Summary: The study revealed that lipid metabolism plays a crucial role in myelin formation and physiological functions in the sciatic nerves of aging SD rats, suggesting it as a potential candidate for nerve aging research.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Xuebin Zhang, Yu Duan, Xiao Zhang, Mengyuan Jiang, Wanrong Man, Yan Zhang, Dexi Wu, Jiye Zhang, Xinglong Song, Congye Li, Jie Lin, Dongdong Sun
Summary: Microvascular complications in diabetes patients, including coronary microvascular injury, are associated with a higher risk of adverse outcomes. This study investigated the mechanisms underlying diabetic coronary microvascular hyperpermeability and found that Adipsin plays a vital role in maintaining the integrity of cardiac microvascular endothelial cells.
Article
Biology
Ji Xu, Bruce J. Nicholson
Summary: This study investigated the characteristics of Cx30 hemichannels using heterologous expression systems. It was found that Cx30 hemichannels are sensitive to voltage and extracellular Ca2+ and show minimal selectivity for small ions but increased permeability for larger anions. Comparison with Cx26 gap junctions in the cochlea revealed differences in ATP permeability, indicating distinct physiological functions of Cx30 and Cx26 in energy distribution.
Article
Neurosciences
Jonathan D. Teo, Oana C. Marian, Alanna G. Spiteri, Madeline Nicholson, Huitong Song, Jasmine X. Y. Khor, Holly P. McEwen, Anjie Ge, Monokesh K. Sen, Laura Piccio, Jessica L. Fletcher, Nicholas J. C. King, Simon S. Murray, Jens C. Bruening, Anthony S. Don
Summary: The sphingolipids GalCer, ST, and SM are crucial for myelin stability and function. By deleting the CerS2 gene and inhibiting the synthesis of C22-C24 sphingolipids, researchers found that the absence of these sphingolipids affects myelin biosynthesis and stability, leading to neurodegeneration. This study highlights the importance of lipid chain length in maintaining the structural integrity of myelin and provides insights into the molecular mechanism of microglial activation.
Article
Cell Biology
Haixin Liu, Minsheng Yang, Guofeng Wu, Lianjun Yang, Yanlin Cao, Chun Liu, Zhiwen Tan, Yanglei Jin, Jiasong Guo, Lixin Zhu
CONNECTIVE TISSUE RESEARCH
(2019)
Article
Neurosciences
Jinkun Wen, Dandan Tan, Lixia Li, Xianghai Wang, Mengjie Pan, Jiasong Guo
EXPERIMENTAL NEUROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Xican Li, Yulu Xie, Ke Li, Aizhi Wu, Hong Xie, Qian Guo, Penghui Xue, Yerkingul Maleshibek, Wei Zhao, Jiasong Guo, Dongfeng Chen
Article
Materials Science, Biomaterials
Zhiming Zhang, Guofeng Wu, Yanlin Cao, Chun Liu, Yanglei Jin, Yihan Wang, Lianjun Yang, Jiasong Guo, Lixin Zhu
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Neurosciences
Dandan Tan, Jinkun Wen, Lixia Li, Xianghai Wang, Changhui Qian, Mengjie Pan, Muhua Lai, Junyao Deng, Xiaofang Hu, Haowen Zhang, Jiasong Guo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Lixia Li, Yuanyuan Li, Zhihao Fan, Xianghai Wang, Zhenlin Li, Jinkun Wen, Junyao Deng, Dandan Tan, Mengjie Pan, Xiaofang Hu, Haowen Zhang, Muhua Lai, Jiasong Guo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Cell Biology
Minsheng Yang, Haixin Liu, Yihan Wang, Guofeng Wu, Sujun Qiu, Chun Liu, Zhiwen Tan, Jiasong Guo, Lixin Zhu
CONNECTIVE TISSUE RESEARCH
(2019)
Article
Cell Biology
Dandan Tan, Haowen Zhang, Junyao Deng, Jingmin Liu, Jinkun Wen, Lixia Li, Xianghai Wang, Mengjie Pan, Xiaofang Hu, Jiasong Guo
Article
Neurosciences
Muhua Lai, Mengjie Pan, Longjiao Ge, Jingmin Liu, Junyao Deng, Xianghai Wang, Lixia Li, Jinkun Wen, Dandan Tan, Haowen Zhang, Xiaofang Hu, Lanya Fu, Yizhou Xu, Zhenlin Li, Xiaozhong Qiu, Gong Chen, Jiasong Guo
EXPERIMENTAL NEUROLOGY
(2020)
Article
Engineering, Biomedical
Xiaofang Hu, Xianghai Wang, Yizhou Xu, Lixia Li, Jingmin Liu, Yutong He, Ying Zou, Lei Yu, Xiaozhong Qiu, Jiasong Guo
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Engineering, Biomedical
Yazhong Bu, Xianghai Wang, Lixia Li, Xiaofang Hu, Dandan Tan, Zhenlin Li, Muhua Lai, Xiaozhong Qiu, Feifei Sun, Hufei Wang, Fei Yang, Decheng Wu, Jiasong Guo
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Immunology
Jiawei Xu, Jinkun Wen, Lanya Fu, Liqiang Liao, Ying Zou, Jiaqi Zhang, Junyao Deng, Haowen Zhang, Jingmin Liu, Xianghai Wang, Daming Zuo, Jiasong Guo
Summary: The depletion of RhoA in macrophages has a negative impact on Wallerian degeneration and nerve regeneration, mainly due to impaired migration and phagocytosis of macrophages resulting from disrupted RhoA/ROCK/MLCK pathway. Since previous research has shown that RhoA inhibition in neurons promotes axonal regeneration, the study highlights the importance of considering cellular specificity of RhoA-targeted drugs in future applications for treating peripheral nerve injuries.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Jingmin Liu, Lixia Li, Ying Zou, Lanya Fu, Xinrui Ma, Haowen Zhang, Yizhou Xu, Jiawei Xu, Jiaqi Zhang, Mi Li, Xiaofang Hu, Zhenlin Li, Xianghai Wang, Hao Sun, Hui Zheng, Lixin Zhu, Jiasong Guo
Summary: Wallerian degeneration, the degeneration of distal axons and myelin after nerve injury, is crucial for nerve regeneration. This study found that microtubule dynamics are involved in this process, with microtubule stabilization promoting degeneration and dedifferentiation, while microtubule destabilization inhibiting these processes.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ying Zou, Jiaqi Zhang, Jiawei Xu, Lanya Fu, Yizhou Xu, Xianghai Wang, Zhenlin Li, Lixin Zhu, Hao Sun, Hui Zheng, Jiasong Guo
Summary: SIRT6 plays a crucial role in macrophage function following peripheral nerve injury, with its inhibition impairing migration, phagocytosis, and M2 polarization of macrophages, thus suggesting it as a potential therapeutic target for peripheral nerve injury.
CELL AND BIOSCIENCE
(2021)
Article
Neurosciences
Changnan Xie, Yihan Wang, Jinfeng Wang, Yizhou Xu, Haining Liu, Jiasong Guo, Lixin Zhu
Summary: This study found that Perlecan is specifically expressed in the basement membranes (BMs) of the spinal cord and undergoes degradation/remodeling after spinal cord injury (SCI). Overexpression of Perlecan significantly enhances locomotor recovery and neural regeneration, reduces blood-spinal cord barrier (BSCB) permeability, and decreases the neuroinflammatory response. Perlecan interacts with integrin beta 1 and inhibits downstream signaling pathway to improve BSCB integrity.
MOLECULAR NEUROBIOLOGY
(2023)