SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages

Sirtuin 6 attenuates angiotensin II-induced vascular adventitial aging in rat aortae by suppressing the NF-κB pathway

(2021) Xiaoqian Liu et al.   HYPERTENSION RESEARCH

SIRT6 Negatively Regulates Schwann Cells Dedifferentiation via Targeting c-Jun During Wallerian Degeneration After Peripheral Nerve Injury

(2021) Ying Zou et al.   MOLECULAR NEUROBIOLOGY

Protective Effects of SIRT6 Against Inflammation, Oxidative Stress, and Cell Apoptosis in Spinal Cord Injury

(2020) Chen Zhaohui et al.   INFLAMMATION

Lithium Loaded Octa‐Poly(Ethylene Glycol) Based Adhesive Facilitates Axon Regeneration and Reconnection of Transected Peripheral Nerves

(2020) Yazhong Bu et al.   Advanced Healthcare Materials

Characterising cellular and molecular features of human peripheral nerve degeneration

(2020) Matthew B. Wilcox et al.   Acta Neuropathologica Communications

Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration

(2020) Giovanni Ferrara et al.   Journal of Neuroinflammation

Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching

(2020) Tzu-Chieh Huang et al.   Journal of Neuroinflammation

TRPM7 modulates macrophage polarization by STAT1/STAT6 pathways in RAW264.7 cells

(2020) Lingling Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

(2019) Lixia Li et al.   Frontiers in Cellular Neuroscience

L-Fucose ameliorates DSS-induced acute colitis via inhibiting macrophage M1 polarization and inhibiting NLRP3 inflammasome and NF-kB activation

(2019) Ruohang He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SIRT6, a Mammalian deacylase with multitasking abilities

(2019) Andrew R Chang et al.   PHYSIOLOGICAL REVIEWS

SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors α

(2019) Hui Jiang et al.   Frontiers in Pharmacology

Macrophage biology in the peripheral nervous system after injury

(2018) Richard E. Zigmond et al.   PROGRESS IN NEUROBIOLOGY

SIRT6 inhibits TNF-α-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway

(2017) Yanhao He et al.   EXPERIMENTAL CELL RESEARCH

Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production

(2017) Gui-Ru Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation

(2017) Wei Zhang et al.   NEUROSCIENCE

Expression of membrane progesterone receptors (mPRs) in rat peripheral glial cell membranes and their potential role in the modulation of cell migration and protein expression

(2017) Luca F. Castelnovo et al.   STEROIDS

Lentivirus-Mediated RNA Interference Targeting RhoA Slacks the Migration, Proliferation, and Myelin Formation of Schwann Cells

(2016) Jinkun Wen et al.   MOLECULAR NEUROBIOLOGY

Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury

(2015) Peiwen Chen et al.   ACTA NEUROPATHOLOGICA

Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing

(2015) Rajarajan A. Thandavarayan et al.   EXPERIMENTAL DERMATOLOGY

Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development

(2015) Yaosen Wu et al.   Scientific Reports

Novel Markers to Delineate Murine M1 and M2 Macrophages

(2015) Kyle A. Jablonski et al.   PLoS One

Collagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization

(2014) Peiwen Chen et al.   ACTA NEUROPATHOLOGICA

Discovery of Novel and Selective SIRT6 Inhibitors

(2014) Marco Daniele Parenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sirt2 suppresses inflammatory responses in collagen-induced arthritis

(2013) Jiangtao Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophages: Supportive cells for tissue repair and regeneration

(2013) Bénédicte Chazaud   IMMUNOBIOLOGY

Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve

(2011) Magdalena Bremer et al.   GLIA

Wallerian degeneration: the innate-immune response to traumatic nerve injury

(2011) Shlomo Rotshenker   Journal of Neuroinflammation

Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury

(2011) Andrew D Gaudet et al.   Journal of Neuroinflammation

Pals1 Is a Major Regulator of the Epithelial-Like Polarization and the Extension of the Myelin Sheath in Peripheral Nerves

(2010) M. Ozcelik et al.   JOURNAL OF NEUROSCIENCE

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Requirement of Myeloid Cells for Axon Regeneration

(2008) B. Barrette et al.   JOURNAL OF NEUROSCIENCE