Nanomedicine: Tiny Particles and Machines Give Huge Gains

Tiny Grains Give Huge Gains: Nanocrystal-Based Signal Amplification for Biomolecule Detection

(2013) Sheng Tong et al.   ACS Nano

Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging

(2013) Gang Bao et al.   Annual Review of Biomedical Engineering

Genome Engineering at the Dawn of the Golden Age

(2013) David J. Segal et al.   Annual Review of Genomics and Human Genetics

TALEN-based Gene Correction for Epidermolysis Bullosa

(2013) Mark J Osborn et al.   MOLECULAR THERAPY

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

(2013) Prashant Mali et al.   NATURE BIOTECHNOLOGY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish

(2013) An Xiao et al.   NUCLEIC ACIDS RESEARCH

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

(2013) Thomas J. Cradick et al.   NUCLEIC ACIDS RESEARCH

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Magnetic Targeting of Human Mesenchymal Stem Cells with Internalized Superparamagnetic Iron Oxide Nanoparticles

(2013) Natalia Landázuri et al.   Small

Quantum Dot–Fluorescent Protein FRET Probes for Sensing Intracellular pH

(2012) Allison M. Dennis et al.   ACS Nano

In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region

(2012) Guosong Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration

(2012) Sandra Cristea et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease

(2012) Ning Sun et al.   Molecular BioSystems

InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment

(2012) Virgilio Brunetti et al.   Nanoscale

RNA-guided genetic silencing systems in bacteria and archaea

(2012) Blake Wiedenheft et al.   NATURE

FLASH assembly of TALENs for high-throughput genome editing

(2012) Deepak Reyon et al.   NATURE BIOTECHNOLOGY

TAL effector RVD specificities and efficiencies

(2012) Jana Streubel et al.   NATURE BIOTECHNOLOGY

A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes

(2012) Jonathan L Schmid-Burgk et al.   NATURE BIOTECHNOLOGY

Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging

(2012) Mya S Thu et al.   NATURE MEDICINE

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

(2012) Cherie L. Ramirez et al.   NUCLEIC ACIDS RESEARCH

Targeting G with TAL Effectors: A Comparison of Activities of TALENs Constructed with NN and NK Repeat Variable Di-Residues

(2012) Michelle L. Christian et al.   PLoS One

Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice

(2012) S. A. Stanley et al.   SCIENCE

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

(2012) Z. Cheng et al.   SCIENCE

Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains

(2012) Le Cong et al.   Nature Communications

ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites

(2011) Thomas J Cradick et al.   BMC BIOINFORMATICS

Self-Assembly of Phospholipid–PEG Coating on Nanoparticles through Dual Solvent Exchange

(2011) Sheng Tong et al.   NANO LETTERS

Targeted gene disruption in somatic zebrafish cells using engineered TALENs

(2011) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Exchange-coupled magnetic nanoparticles for efficient heat induction

(2011) Jae-Hyun Lee et al.   Nature Nanotechnology

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

(2011) Claudio Mussolino et al.   NUCLEIC ACIDS RESEARCH

Gold nanostars as thermoplasmonic nanoparticles for optical heating

(2011) R. Rodríguez-Oliveros et al.   OPTICS EXPRESS

Assembly of Designer TAL Effectors by Golden Gate Cloning

(2011) Ernst Weber et al.   PLoS One

p53 Gene Repair with Zinc Finger Nucleases Optimised by Yeast 1-Hybrid and Validated by Solexa Sequencing

(2011) Frank Herrmann et al.   PLoS One

Targeted Genome Editing Across Species Using ZFNs and TALENs

(2011) Andrew J. Wood et al.   SCIENCE

Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis

(2011) Mo-Tao Zhu et al.   TOXICOLOGY LETTERS

Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy

(2010) Fahima Dilnawaz et al.   BIOMATERIALS

Self-Confirming “AND” Logic Nanoparticles for Fault-Free MRI

(2010) Jin-sil Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coating Optimization of Superparamagnetic Iron Oxide Nanoparticles for High T2Relaxivity

(2010) Sheng Tong et al.   NANO LETTERS

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

(2010) Josiane E. Garneau et al.   NATURE

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

(2010) Yannick Doyon et al.   NATURE METHODS

CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

(2010) Luciano A. Marraffini et al.   NATURE REVIEWS GENETICS

Nanomedicine

(2010) Betty Y.S. Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR/Cas, the Immune System of Bacteria and Archaea

(2010) P. Horvath et al.   SCIENCE

Micro- and nanotechnologies for intelligent and responsive biomaterial-based medical systems

(2009) Mary Caldorera-Moore et al.   ADVANCED DRUG DELIVERY REVIEWS

Designer Biomaterials for Nanomedicine

(2009) Nishit Doshi et al.   ADVANCED FUNCTIONAL MATERIALS

All-in-One Target-Cell-Specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery

(2009) Jae-Hyun Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Critical Enhancements of MRI Contrast and Hyperthermic Effects by Dopant-Controlled Magnetic Nanoparticles

(2009) Jung-tak Jang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High throughput methods applied in biomaterial development and discovery

(2009) Andrew L. Hook et al.   BIOMATERIALS

Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas

(2009) G. von Maltzahn et al.   CANCER RESEARCH

RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex

(2009) Caryn R. Hale et al.   CELL

Iron Oxide Nanoparticle Platform for Biomedical Applications

(2009) J. Xie et al.   CURRENT MEDICINAL CHEMISTRY

MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells

(2009) Jagadeesh Setti Guthi et al.   MOLECULAR PHARMACEUTICS

Gold nanocages covered by smart polymers for controlled release with near-infrared light

(2009) Mustafa S. Yavuz et al.   NATURE MATERIALS

A novel magnetic crystal–lipid nanostructure for magnetically guided in vivo gene delivery

(2009) Yoshihisa Namiki et al.   Nature Nanotechnology

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

A Simple Cipher Governs DNA Recognition by TAL Effectors

(2009) M. J. Moscou et al.   SCIENCE

Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging

(2009) Santimukul Santra et al.   Small

Nanoparticles for photoacoustic imaging

(2009) Xinmai Yang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Nanoscaling Laws of Magnetic Nanoparticles and Their Applicabilities in Biomedical Sciences

(2008) Young-wook Jun et al.   ACCOUNTS OF CHEMICAL RESEARCH

Noble Metals on the Nanoscale: Optical and Photothermal Properties and Some Applications in Imaging, Sensing, Biology, and Medicine

(2008) Prashant K. Jain et al.   ACCOUNTS OF CHEMICAL RESEARCH

Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery

(2008) Monty Liong et al.   ACS Nano

Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging

(2008) Ji-Ho Park et al.   ADVANCED MATERIALS

Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery

(2008) Ji-Ho Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery

(2008) Jaeyun Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hollow Manganese Oxide Nanoparticles as Multifunctional Agents for Magnetic Resonance Imaging and Drug Delivery

(2008) Jongmin Shin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Magnetic nanoparticles with dual functional properties: Drug delivery and magnetic resonance imaging

(2008) Tapan K. Jain et al.   BIOMATERIALS

Quantum Dot−Fluorescent Protein Pairs as Novel Fluorescence Resonance Energy Transfer Probes

(2008) Allison M. Dennis et al.   NANO LETTERS

Targeted Gold Nanoparticles Enable Molecular CT Imaging of Cancer

(2008) Rachela Popovtzer et al.   NANO LETTERS

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells

(2008) Christopher J Gannon et al.   JOURNAL OF NANOBIOTECHNOLOGY

DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases

(2007) Tatjana I Cornu et al.   MOLECULAR THERAPY