Article
Allergy
Marie Bastin, Warner W. W. Carr, Carla M. M. Davis, David M. M. Fleischer, Jay A. A. Lieberman, S. Shahzad Mustafa, Thibault Helleputte, Timothee Bois, Dianne E. E. Campbell, Todd D. D. Green, Matthew Greenhawt
Summary: This study examined the serum-specific IgG4 and IgE levels in peanut-allergic children receiving Viaskin Peanut treatment, and found that IgG4 rise most clearly differentiated treatment responders from non-responders. IgG4/IgE ratios >20.1 and the combination of Ara h 1 and peanut IgG4/IgE showed moderate ability to predict treatment response.
Article
Allergy
Maria Suprun, Paul Kearney, Clive Hayward, Heather Butler, Robert Getts, Scott H. Sicherer, Paul J. Turner, Dianne E. Campbell, Hugh A. Sampson
Summary: An epitope-based predictor was able to accurately identify the cumulative tolerated doses (CTDs) of peanut protein and assign patients into high, moderate, or low dose-reactivity groups. Patients in the high group were more likely to tolerate specific doses, while those in the low group were less tolerant.
Article
Immunology
Xiaoying Zhou, Wong Yu, Shu-Chen Lyu, Claudia Macaubas, Bryan Bunning, Ziyuan He, Elizabeth D. Mellins, Kari C. Nadeau
Summary: This study found that peanut allergen can drive the differentiation of specific antigen-presenting cell subsets in peanut-allergic individuals. The interaction between CD209(+) dendritic cells and peanut-specific CD4(+) T cells reinforces Th2 cytokine expression in a positive feedback loop, which may explain the persistence of established food allergy. Initiation of oral immunotherapy in peanut-allergic patients leads to a decrease in CD209(+) dendritic cells, suggesting a therapeutic effect by breaking the cycle of positive feedback.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Allergy
Justine Calise, Hannah DeBerg, Nahir Garabatos, Sugandhika Khosa, Veronique Bajzik, Lorena Botero Calderon, Kelly Aldridge, Mario Rosasco, Brian C. Ferslew, Tong Zhu, Ronald Smulders, Lisa M. Wheatley, Tanya M. Laidlaw, Tielin Qin, Gurunadh R. Chichili, Daniel C. Adelman, Mary Farrington, David Robinson, David Jeong, Stacie M. Jones, Srinath Sanda, David Larson, William W. Kwok, Carolyn Baloh, Gerald T. Nepom, Erik Wambre
Summary: This study found that inherent qualities of cell response at baseline can influence the response to peanut oral immunotherapy in peanut-allergic individuals. Peanut allergy can be broadly classified into at least two subtypes based on the proportion of specific T-cell subsets, with distinct immunologic and clinical characteristics. Stratifying patients based on their peanut-specific T-cell profile may help identify which immunotypes will respond best to different therapies in clinical settings.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Christopher P. P. Mattison, Zhongqi He, Dunhua Zhang, Rebecca Dupre, Steven W. W. Lloyd
Summary: Food allergy is caused by IgE antibodies that recognize harmless food proteins as threats. Glandless cottonseed, a new food source, may contain allergenic seed storage proteins. Research found that 25% of cottonseed extracts showed significant binding to peanut and tree nut allergic IgE. The study suggests that the cotton vicilin and legumin proteins should be considered for future allergen risk assessments.
Article
Immunology
Michal Rudnik, Amela Hukara, Ievgeniia Kocherova, Suzana Jordan, Janine Schniering, Vincent Milleret, Martin Ehrbar, Karin Klingel, Carol Feghali-Bostwick, Oliver Distler, Przemyslaw Blyszczuk, Gabriela Kania
Summary: The study identified activated profibrotic features in CD14(+) monocytes and CD14(+) pulmonary macrophages in Systemic sclerosis (SSc) patients, highlighting their capability to produce profibrotic fibronectin. This suggests that tissue-infiltrating CD14(+) monocytes/macrophages play a role in ECM production in the pathogenesis of SSc.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Kensuke Miyake, Sho Shibata, Soichiro Yoshikawa, Hajime Karasuyama
Summary: Basophils are rare granulocytes that play crucial roles in allergic inflammation by releasing effector molecules to regulate immune responses and allergic disorders. They are recruited to inflamed tissues and activated in various ways, highlighting their versatile functions in the immune system.
Review
Allergy
Paul Engeroff, Monique Vogel
Summary: IgE can bind to two receptors, playing different roles on different cells, inducing allergic reactions on one hand and participating in IgE regulation and antigen presentation on the other. In inflammation and immune homeostasis, CD23 plays an important modulatory role.
Article
Allergy
Paul Engeroff, Kevin Plattner, Federico Storni, Franziska Thoms, Kayluz Frias Boligan, Lukas Muerner, Alexander Eggel, Stephan von Gunten, Martin F. Bachmann, Monique Vogel
Summary: The study demonstrates that glycan-specific IgG anti-IgE autoantibodies can downregulate serum IgE levels and anaphylactic activity, providing potential therapeutic implications for allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Maddalena Sirufo, Francesca De Pietro, Lia Ginaldi, Massimo De Martinis
Summary: Gender differences are increasingly recognized in medicine, but specific gender-targeted studies are lacking. Considering gender pharmacology is crucial for optimizing drug therapies. Further development of gender research can identify potential risks and benefits between genders and enable personalized medicine.
Article
Immunology
Kamal Srivastava, Mingzhuo Cao, Ozkan Fidan, Yanmei Shi, Nan Yang, Anna Nowak-Wegrzyn, Mingsan Miao, Jixun Zhan, Hugh A. Sampson, Xiu-Min Li
Summary: This study evaluated the combination of oral Berberine-containing natural medicine with a boiled peanut oral immunotherapy as a treatment for food allergy in a murine model. The results showed that the treatment induced long-term tolerance to peanut and was associated with significant reduction in IgE levels and symptom scores. The changes in gut microbiota were found to be correlated with therapeutic outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
James W. Krempski, Jyoti K. Lama, Koji Iijima, Takao Kobayashi, Mayumi Matsunaga, Hirohito Kita
Summary: This study developed a mouse model to simulate the effects of early introduction of peanut products on peanut allergies. The results showed that ingestion of a peanut product protected mice from peanut allergy induced by environmental exposure. The CTLA-4 pathway, which regulates Tfh cell responses, played a pivotal role in this protection.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Xiao-Jing Ling, Ji-Fu Wei, Ying Zhu
Summary: The incidence of allergic diseases has increased significantly in recent decades, making it a major global public health problem. Allergic diseases such as dermatitis, rhinitis, asthma, and food allergies are mediated by immunoglobulin E (IgE), which plays a central role in these diseases. By understanding the mechanism of allergic diseases, new therapeutic strategies have been developed to interfere with IgE and have received great attention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Marta Paolucci, Valentine Homere, Ying Waeckerle-Men, Natascha Wuillemin, Dimitri Bieli, Niccolo Pengo, Tiziana Sonati, Thomas M. Kuendig, Pal Johansen
Summary: This study aimed to develop a mouse model of peanut-allergic anaphylaxis that resembles human anaphylaxis. Different mouse strains were compared for their immunological and clinical responses to peanut sensitization. The C3H mouse strain was found to be suitable for the development of a peanut-allergic anaphylaxis model, showing similar pre-clinical, humoral, and cellular responses as observed in human patients.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
