A mouse model of the LEAP study reveals a role for CTLA-4 in preventing peanut allergy induced by environmental peanut exposure

The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis

(2021) Michael D. Kulis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells

(2021) Murat Tekguc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Epicutaneous sensitization to food allergens in atopic dermatitis: What do we know?

(2019) Elizabeth Huiwen Tham et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

The Genetics of Food Allergy

(2018) Cristina A. Carter et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Circulating allergen-specific T H 2 lymphocytes: CCR4 + rather than CLA + is the predominant phenotype in peanut-allergic subjects

(2018) Lars H. Blom et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immune quiescence in the oral mucosa is maintained by a uniquely large population of highly activated Foxp3+ regulatory T cells

(2018) Joo-Young Park et al.   Mucosal Immunology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade

(2018) Charlotte E. Ariyan et al.   Cancer Immunology Research

Food allergy

(2018) Harald Renz et al.   Nature Reviews Disease Primers

Genetic diversity between mouse strains allows identification of the CC027/GeniUnc strain as an orally reactive model of peanut allergy

(2018) Kelly Orgel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice

(2017) Joseph J. Dolence et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel

(2017) Alkis Togias et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Follicular helper T cells mediate IgE antibody response to airborne allergens

(2017) Takao Kobayashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells

(2017) Jian Ye et al.   Cell Reports

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

(2016) Jianjun Gao et al.   CELL

Molecular and cellular mechanisms of food allergy and food tolerance

(2016) R. Sharon Chinthrajah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prevention of food allergy

(2016) George du Toit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

(2016) Yohko Kitagawa et al.   NATURE IMMUNOLOGY

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

(2016) Katrin Klocke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology of childhood peanut allergy

(2015) Ashley A. Dyer et al.   ALLERGY AND ASTHMA PROCEEDINGS

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

(2015) Helen A. Brough et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy

(2015) George Du Toit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

(2015) H.-J. Kim et al.   SCIENCE

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

(2015) Xiumei Hong et al.   Nature Communications

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells

(2014) Peter T. Sage et al.   IMMUNITY

Skin exposure promotes a Th2-dependent sensitization to peanut allergens

(2014) Leticia Tordesillas et al.   JOURNAL OF CLINICAL INVESTIGATION

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

(2014) Chun Jing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution of peanut protein in the home environment

(2013) Helen A. Brough et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model

(2011) H. Yamashita et al.   ALLERGY

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

(2011) John J. Worthington et al.   GASTROENTEROLOGY

Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants

(2011) Nicholas J. Osborne et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Household peanut consumption as a risk factor for the development of peanut allergy

(2009) Adam T. Fox et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL