Article
Biochemistry & Molecular Biology
Guangdong Li, Dongying Lv, Yujun Yao, Hao Wu, Jing Wang, Shoulong Deng, Yukun Song, Shengyu Guan, Likai Wang, Wenkui Ma, Hai Yang, Laiqing Yan, Jinlong Zhang, Pengyun Ji, Lu Zhang, Zhengxing Lian, Guoshi Liu
Summary: The study demonstrated that transgenic sheep overexpressing melatonin showed increased resistance to Brucella infection, with higher serum melatonin levels and altered expression of immune-related genes. These findings suggest a potential role for melatonin in enhancing immunity against infectious diseases.
Article
Agriculture, Dairy & Animal Science
Wenbo Ge, Hongwei Duan, Jianling Zeng, Xingxu Zhao, Jianyong Li, Junjie Hu
Summary: This study investigated the distribution of melatonin and its receptors in the sheep uterus, as well as its protective effects against inflammation in endometrial epithelial cells. The results showed that melatonin reduced the expression of inflammatory factors and inhibited the activation of inflammatory signaling pathways. These protective effects were mediated by melatonin receptors and the PI3K/AKT pathway.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Plant Sciences
Yuexin Zhang, Maohua Dai, Zhe Wu, Shuai Wang, Yapeng Fan, Kesong Ni, Xuke Lu, Xiaoyu Liu, Mengyue Liu, Wenhua Chen, Xiugui Chen, Delong Wang, Junjuan Wang, Lixue Guo, Lanjie Zhao, Xiuping Wang, Wuwei Ye
Summary: In this study, the characteristics of cotton CANDs were analyzed by bioinformatics, including their phylogenetic relationships, expression patterns, and responses to environmental stress. It was found that a group of CANDs may function as cotton melatonin receptors and the expression of GhCANDs increased under melatonin induction. Furthermore, a potential cotton melatonin receptor was identified and its silencing resulted in decreased salt tolerance and interactions with multiple membrane proteins.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cell Biology
Junqiang Zhang, Yuan Fang, Dongdong Tang, Xingyu Xu, Xiaoqian Zhu, Shusheng Wu, Hui Yu, Huiru Cheng, Ting Luo, Qunshan Shen, Yang Gao, Cong Ma, Yajing Liu, Zhaolian Wei, Xiaoyu Chen, Fangbiao Tao, Xiaojin He, Yunxia Cao
Summary: This study explores the protective effect and molecular mechanism of melatonin in cisplatin-induced oxidative stress in testicular tissue and Leydig cells. The results show that melatonin reduces oxidative stress and upregulates SIRT1/Nrf2 signaling, preventing the apoptosis of Leydig cells caused by cisplatin.
Article
Plant Sciences
Kyoungwhan Back
Summary: The biosynthesis, levels, signaling, and possible roles of melatonin and its metabolites in plants were summarized. Different plants have differential levels of melatonin and its metabolites, leading to varying physiological effects. Melatonin mediates important functions in growth stimulation and stress tolerance through its antioxidant activity and function in activating the MAPK cascade.
Article
Cell & Tissue Engineering
Wenming Li, Wenhao Li, Wei Zhang, Hongzhi Wang, Lei Yu, Peng Yang, Yi Qin, Minfeng Gan, Xing Yang, Lixin Huang, Yuefeng Hao, Dechun Geng
Summary: This study found that melatonin (MT) can effectively treat SONFH by inhibiting ferroptosis through the regulation of growth differentiation factor 15 (GDF15) expression.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, Research & Experimental
Emine Mulayim, Ibrahim Fatih Karababa, Halit Akbas, Huseyin Bayazit, Salih Selek
Summary: The study revealed that the MTNR1B gene-1193C>T polymorphism may play a role in BD-I genetic etiology and contribute to the sleep disorder and circadian rhythm disorder observed in these patients.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Environmental Sciences
Xue-Ting Shi, Hua-Long Zhu, Xiao-Feng Xu, Yong-Wei Xiong, Li-Min Dai, Guo-Xiang Zhou, Wei-Bo Liu, Yu-Feng Zhang, De-Xiang Xu, Hua Wang
Summary: This study found that melatonin treatment significantly alleviated environmental cadmium-induced placental angiogenesis disorder and reduction of VEGF-A level. Mechanistically, melatonin reversed the downregulation of VEGF-A protein expression induced by environmental cadmium by inhibiting glucocorticoid receptor (GR) activation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Genetics & Heredity
Hongwei Duan, Junjie Hu, Longfei Xiao, Jianshu Lv, Yong Zhang, Xingxu Zhao
Summary: In sheep granulosa cells (GCs), the production of melatonin was inhibited by E2 through an ERA and ERB-mediated process, which also affected the expression of melatonin receptors.
Article
Biochemistry & Molecular Biology
Estela Fernandez-Alegre, Estibaliz Lacalle, Cristina Soriano-Ubeda, Jose Ramiro Gonzalez-Montana, Juan Carlos Dominguez, Adriana Casao, Felipe Martinez-Pastor
Summary: Melatonin plays an important role in reproduction through its antioxidant, hormonal, and paracrine actions. The membrane receptors MT1/MT2 have been found on spermatozoa from bull and red deer, with different functions. MT1 is related to sperm viability preservation in bull, while MT2 could modulate cell functionality to prevent excess ROS produced by mitochondria. In red deer, the resistance to melatonin and receptor activation may be due to the high circulating melatonin levels during the breeding season, but the receptors could still be involved in mitochondrial protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Wei Chou Tseng, Veronica Reinhart, Thomas A. Lanz, Mark L. Weber, Jincheng Pang, Kevin Xuong Vinh Le, Robert D. Bell, Patricio O'Donnell, Derek L. Buhl
Summary: The A391T missense mutation in ZIP8 results in reduced zinc transport, altered glutamate signaling, and an exacerbated immune and inflammatory response. Re-expression of wild-type ZIP8 or application of the zinc chelator ZX1 can rescue the observed phenotypes. These findings provide novel therapeutic targets relevant to schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yongfu He, Ming Gao, Weizheng Yang, Shaochen Sun, Qiang Wang, Ling Gu
Summary: This study systematically investigated the histone modification changes in oocytes during aging, revealing significant alterations in the status of H4K12ac and H3K4me3. The reduction in HDAC1 protein was identified as a contributor to these changes, and it was found that elevated levels of reactive carbonyl species (RCS) induced HDAC1 degradation, thereby influencing histone modification state. Additionally, supplementation of melatonin prevented the loss of HDAC1 protein and partially corrected the altered histone modification status in aged oocytes.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yin Zhang, Peifang Cong, Changci Tong, Hongxu Jin, Yunen Liu, Mingxiao Hou
Summary: The study demonstrated that melatonin pretreatment alleviated blast-induced behavioral abnormalities in mice and maintained HPG axis hormone homeostasis in rats. Melatonin upregulated Nrf2/HO-1 expression, inhibited NF-kappa B expression, and reversed blast-induced oxidative stress, inflammation, and apoptosis. This suggests that melatonin could be a potential treatment for blast-induced HPG axis hormonal and behavioral abnormalities.
Article
Zoology
Zhi-Ming Yang, Yang-Yang Yan, Yong Wu, Na Yu, Ze-Wen Liu
Summary: Female wolf spiders are meticulous caregivers, carrying egg sacs and spiderlings during reproduction. This study identified 23 nuclear receptors in the genome of Pardosa pseudoannulata, including the key regulators EcR and USP-1, which are involved in ecdysteroid signaling. Interference with EcR and USP-1 led to impaired spiderling development and non-viable eggs in the egg sacs, highlighting the importance of ecdysteroid signaling in spider development and reproduction.
ZOOLOGICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Elia Ciani, Trude M. Haug, Gersende Maugars, Finn-Arne Weltzien, Jack Falcon, Romain Fontaine
Summary: Melatonin regulates the synthesis and release of pituitary hormones to synchronize physiological rhythms with environmental conditions, affecting processes such as growth and metabolism. It can act directly on the pituitary gland or indirectly through brain centers that control hormone production and release.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
D. Chesneau, D. Guillaume, P. Chemineau, B. Malpaux
Article
Agriculture, Dairy & Animal Science
J. A. Abecia, P. Chemineau, A. Gomez, M. Keller, F. Forcada, J. A. Delgadillo
ANIMAL REPRODUCTION SCIENCE
(2016)
Article
Neurosciences
Arsene Ella, Jose A. Delgadillo, Philippe Chemineau, Matthieu Keller
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Psychology, Biological
A. L. Munoz, M. Bedos, R. M. Arona, J. A. Flores, H. Hernandez, C. Moussu, E. F. Briefer, P. Chemineau, M. Keller, J. A. Delgadillo
PHYSIOLOGY & BEHAVIOR
(2016)
Review
Reproductive Biology
Martine Migaud, Lucile Butruille, Anne Duittoz, Delphine Pillon, Martine Batailler
Article
Environmental Sciences
Sylvain Pellerin, Laure Bamiere, Denis Angers, Fabrice Beline, Marc Benoit, Jean-Pierre Butault, Claire Chenu, Caroline Colnenne-David, Stephane De Cara, Nathalie Delame, Michel Doreau, Pierre Dupraz, Philippe Faverdin, Florence Garcia-Launay, Melynda Hassouna, Catherine Henault, Marie-Helene Jeuffroy, Katja Klumpp, Aurelie Metay, Dominic Moran, Sylvie Recous, Elisabeth Samson, Isabelle Savini, Lenaic Pardon, Philippe Chemineau
ENVIRONMENTAL SCIENCE & POLICY
(2017)
Article
Agriculture, Dairy & Animal Science
J. A. Abecia, P. Chemineau, M. Keller, J. A. Delgadillo
REPRODUCTION IN DOMESTIC ANIMALS
(2017)
Article
Reproductive Biology
S. Ramirez, M. Bedos, M. Chasles, H. Hernandez, J. A. Flores, J. Vielma, G. Duarte, M. S. Retana-Marquez, M. Keller, P. Chemineau, J. A. Delgadillo
Article
Agriculture, Dairy & Animal Science
J. Araya, M. Bedos, G. Duarte, H. Hernandez, M. Keller, P. Chemineau, J. A. Delgadillo
ANIMAL PRODUCTION SCIENCE
(2017)
Article
Agriculture, Dairy & Animal Science
J. D. Andrade-Esparza, L. A. Espinoza-Flores, H. Hernandez, P. Chemineau, M. Keller, J. A. Delgadillo
ANIMAL REPRODUCTION SCIENCE
(2018)
Article
Behavioral Sciences
Manon Chasles, Didier Chesneau, Chantal Moussu, Kevin Poissenot, Massimiliano Beltramo, Jose Alberto Delgadillo, Philippe Chemineau, Matthieu Keller
HORMONES AND BEHAVIOR
(2018)
Article
Anthropology
Marie Balasse, Philippe Chemineau, Sara Parisot, Denis Fiorillo, Matthieu Keller
Summary: In temperate Europe, sheep mate in autumn and lamb in the spring. However, current Mediterranean husbandries practice autumn lambing, which has advantages in terms of resource use and seasonal availability. This is made possible by the breeding capabilities of Mediterranean breeds, planning by herders, and the availability of forage resources during autumnal rains. Further research is needed to understand the emergence of autumn and winter sheep births in the western Mediterranean.
JOURNAL OF ARCHAEOLOGICAL METHOD AND THEORY
(2023)
Article
Endocrinology & Metabolism
Maxime A. Meunier, Chantal Porte, Kevin Poissenot, Helene Vacher, Morgane Brachet, Pablo Chamero, Massimiliano Beltramo, Jose A. Abecia, Jose A. Delgadillo, Philippe Chemineau, Matthieu Keller
Summary: In goats, early exposure of spring-born females to sexually active bucks induces an early puberty onset assessed by the first ovulation. This effect is found when females are continuously exposed well before the male breeding season starting in September. The first aim of this study was to evaluate whether a shortened exposure of females to males could also lead to early puberty.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Correction
Agriculture, Dairy & Animal Science
D. Chesneau, D. Guillaume, P. Chemineau, B. Malpaux
Article
Agriculture, Dairy & Animal Science
A. L. Munoz, D. Chesneau, H. Hernandez, M. Bedos, G. Duarte, J. Vielma, L. A. Zarazaga, P. Chemineau, M. Keller, J. A. Delgadillo
DOMESTIC ANIMAL ENDOCRINOLOGY
(2017)