Involvement of inflammatory responses in the early development of calcific aortic valve disease: lessons from statin therapy

Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice

(2017) Qingchun Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis

(2016) Calvin Yeang et al.   CURRENT OPINION IN CARDIOLOGY

Circulating regulatory T cells in patients with aortic valve stenosis: Association with disease progression and aortic valve intervention

(2016) Sara Shimoni et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Presence of B cells within aortic valves in patients with aortic stenosis: Relation to severity of the disease

(2016) Joanna Natorska et al.   Journal of Cardiology

Involvement of Immune Cell Network in Aortic Valve Stenosis: Communication between Valvular Interstitial Cells and Immune Cells

(2016) Seung Hyun Lee et al.   Immune Network

Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic ValveCLINICAL PERSPECTIVE

(2015) Rihab Bouchareb et al.   CIRCULATION

Activation of TLR3 Induces Osteogenic Responses in Human Aortic Valve Interstitial Cells through the NF-κB and ERK1/2 Pathways

(2015) Qiong Zhan et al.   International Journal of Biological Sciences

Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans

(2015) Mark J. Graham et al.   JOURNAL OF LIPID RESEARCH

Lipoprotein (a) in calcific aortic valve disease: from genomics to novel drug target for aortic stenosis

(2015) George Thanassoulis   JOURNAL OF LIPID RESEARCH

Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis

(2015) Romain Capoulade et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study

(2015) Sotirios Tsimikas et al.   LANCET

Regulatory T cells in cardiovascular diseases

(2015) Xiao Meng et al.   Nature Reviews Cardiology

Innate and Adaptive Immunity in Calcific Aortic Valve Disease

(2015) Patrick Mathieu et al.   Journal of Immunology Research

Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis

(2014) Suvi Syväranta et al.   ATHEROSCLEROSIS

Effects of shear stress pattern and magnitude on mesenchymal transformation and invasion of aortic valve endothelial cells

(2014) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Lipoprotein(a) Levels, Genotype, and Incident Aortic Valve Stenosis: A Prospective Mendelian Randomization Study and Replication in a Case-Control Cohort

(2014) B. J. Arsenault et al.   Circulation-Cardiovascular Genetics

TGF-  mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease

(2014) C. Munjal et al.   Disease Models & Mechanisms

P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: Implication for calcific aortic valve disease

(2014) Diala El Husseini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease

(2014) Rick A. Nishimura et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac valve cells and their microenvironment—insights from in vitro studies

(2014) Huan Wang et al.   Nature Reviews Cardiology

Potential drug targets for calcific aortic valve disease

(2014) Joshua D. Hutcheson et al.   Nature Reviews Cardiology

Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction

(2014) Catherine M. Otto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-1 Beta Induces an Inflammatory Phenotype in Human Aortic Valve Interstitial Cells Through Nuclear Factor Kappa Beta

(2013) Nicole Nadlonek et al.   ANNALS OF THORACIC SURGERY

Fibrocalcific Aortic Valve Disease

(2013) Robert M. Weiss et al.   CIRCULATION RESEARCH

Elevated Expression of Lipoprotein-Associated Phospholipase A2 in Calcific Aortic Valve Disease

(2013) Ablajan Mahmut et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population

(2013) Pia R. Kamstrup et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic Associations with Valvular Calcification and Aortic Stenosis

(2013) George Thanassoulis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment

(2013) Louise A. Donnelly et al.   Pharmacogenetics and Genomics

The Role of TNF-αand TNF Superfamily Members in the Pathogenesis of Calcific Aortic Valvular Disease

(2013) Antonella Galeone et al.   TheScientificWorldJOURNAL

Getting Leukocytes to the Site of Inflammation

(2013) W. A. Muller   VETERINARY PATHOLOGY

Inflammatory Cytokines Promote Mesenchymal Transformation in Embryonic and Adult Valve Endothelial Cells

(2012) Gretchen J. Mahler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin II promotes aortic valve thickening independent of elevated blood pressure in apolipoprotein-E deficient mice

(2012) Tomohiro Fujisaka et al.   ATHEROSCLEROSIS

Cellular Mechanisms of Aortic Valve Calcification

(2012) Jane A. Leopold   Circulation-Cardiovascular Interventions

Mast Cells in Human Stenotic Aortic Valves Are Associated with the Severity of Stenosis

(2012) E. Wypasek et al.   INFLAMMATION

ATP acts as a survival signal and prevents the mineralization of aortic valve

(2012) Nancy Côté et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcific Aortic Stenosis

(2012) Marc R. Dweck et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Calcific aortic valve stenosis: Immunohistochemical analysis of inflammatory infiltrate

(2012) Ivo Šteiner et al.   PATHOLOGY RESEARCH AND PRACTICE

Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms

(2011) Jordan D. Miller et al.   CIRCULATION RESEARCH

Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2

(2011) Alexandra Kadl et al.   FREE RADICAL BIOLOGY AND MEDICINE

Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis

(2011) Jae-Hoon Choi et al.   IMMUNITY

Circulating Activated and Effector Memory T Cells Are Associated with Calcification and Clonal Expansions in Bicuspid and Tricuspid Valves of Calcific Aortic Stenosis

(2011) R. Winchester et al.   JOURNAL OF IMMUNOLOGY

Impact of Renin-Angiotensin System Blockade Therapy on Outcome in Aortic Stenosis

(2011) M. Adnan Nadir et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Vascular Endothelial Growth Factor–Secreting Mast Cells and Myofibroblasts

(2010) Suvi Syväranta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deficiency of Interleukin-1 Receptor Antagonist Induces Aortic Valve Disease in BALB/c Mice

(2010) Kikuo Isoda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis

(2010) Kwan Leung Chan et al.   CIRCULATION

Lipoprotein(a) as a cardiovascular risk factor: current status

(2010) Børge G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

Tumor Necrosis Factor-  Accelerates the Calcification of Human Aortic Valve Interstitial Cells Obtained from Patients with Calcific Aortic Valve Stenosis via the BMP2-Dlx5 Pathway

(2010) Z. Yu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

Refining Molecular Pathways Leading to Calcific Aortic Valve Stenosis by Studying Gene Expression Profile of Normal and Calcified Stenotic Human Aortic Valves

(2009) Yohan Bossé et al.   Circulation-Cardiovascular Genetics

Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves

(2009) Jae-Hoon Choi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Relationship of Oxidized Phospholipids and Biomarkers of Oxidized Low-Density Lipoprotein With Cardiovascular Risk Factors, Inflammatory Biomarkers, and Effect of Statin Therapy in Patients With Acute Coronary Syndromes

(2009) Alexander E. Fraley et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway

(2008) Philippe Sucosky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone regulatory factors NFATc1 and Osterix in human calcific aortic valves

(2008) Alexandros Alexopoulos et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The role of oxidized phospholipids in atherosclerosis: Fig. 1.

(2008) Judith A. Berliner et al.   JOURNAL OF LIPID RESEARCH

Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis

(2007) Xianzhong Meng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY