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Title
Direct activation of full-length proapoptotic BAK
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 11, Pages E986-E995
Publisher
Proceedings of the National Academy of Sciences
Online
2013-02-13
DOI
10.1073/pnas.1214313110
References
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Related references
Note: Only part of the references are listed.- Direct and selective small-molecule activation of proapoptotic BAX
- (2012) Evripidis Gavathiotis et al. Nature Chemical Biology
- Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function
- (2012) Pedro Eitz Ferrer et al. PLoS One
- Reconstitution of Proapoptotic BAK Function in Liposomes Reveals a Dual Role for Mitochondrial Lipids in the BAK-driven Membrane Permeabilization Process
- (2011) Olatz Landeta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
- (2011) Haiming Dai et al. JOURNAL OF CELL BIOLOGY
- A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
- (2011) Fabien Llambi et al. MOLECULAR CELL
- Photoreactive Stapled BH3 Peptides to Dissect the BCL-2 Family Interactome
- (2010) Craig R. Braun et al. CHEMISTRY & BIOLOGY
- Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers
- (2010) Kyoung Joon Oh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak
- (2010) Han Du et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
- (2010) Wyndham H Wilson et al. LANCET ONCOLOGY
- BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
- (2010) Evripidis Gavathiotis et al. MOLECULAR CELL
- Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices
- (2009) Grant Dewson et al. MOLECULAR CELL
- Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis
- (2009) Hyungjin Kim et al. MOLECULAR CELL
- Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax
- (2008) Jonathan F. Lovell et al. CELL
- Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins
- (2008) Cheol-Min Park et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator
- (2008) Hongfei Wang et al. JOURNAL OF STRUCTURAL BIOLOGY
- To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions
- (2008) Grant Dewson et al. MOLECULAR CELL
- BAX activation is initiated at a novel interaction site
- (2008) Evripidis Gavathiotis et al. NATURE
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