The Chemistry and Biology of Theta Defensins

The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif.

(2014) Anne C. Conibear et al.   CHEMBIOCHEM

Macaque Paneth Cells Express Lymphoid Chemokine CXCL13 and Other Antimicrobial Peptides Not Previously Described as Expressed in Intestinal Crypts

(2013) Carissa M. Lucero et al.   Clinical and Vaccine Immunology

Cyclotide biosynthesis

(2013) David J Craik et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Form and Function in Cyclic Peptide Natural Products: A Pharmacokinetic Perspective

(2013) Andrew T. Bockus et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Two-step Biosynthesis of Cyclic Peptides from Linear Precursors in a Member of the Plant Family Caryophyllaceae Involves Cyclization by a Serine Protease-like Enzyme

(2013) Carla J. S. Barber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cyclic Cystine Ladder in θ-Defensins Is Important for Structure and Stability, but Not Antibacterial Activity

(2013) Anne C. Conibear et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

(2013) Fabrizio Giordanetto et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Compensatory Mutation Provides Resistance to Disparate HIV Fusion Inhibitor Peptides and Enhances Membrane Fusion

(2013) Matthew P. Wood et al.   PLoS One

A non-cyclic baboon θ-defensin derivative exhibiting antimicrobial activity against the phytopathogen Verticillium dahliae

(2012) Mi Ni et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Structural Characterization of the Cyclic Cystine Ladder Motif of θ-Defensins

(2012) Anne C. Conibear et al.   BIOCHEMISTRY

Efficient one-pot cyclization/folding of Rhesus θ-defensin-1 (RTD-1)

(2012) Teshome L. Aboye et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Circular Micro-Proteins and Mechanisms of Cyclization

(2012) Brendon F. Conlan et al.   CURRENT PHARMACEUTICAL DESIGN

Discovery and Applications of Disulfide-Rich Cyclic Peptides

(2012) Masa Cemazar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Circular Proteins from Plants and Fungi

(2012) Ulf Göransson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylethanolamine Binding Is a Conserved Feature of Cyclotide-Membrane Interactions

(2012) Sónia Troeira Henriques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

θ-Defensins: Cyclic Peptides with Endless Potential: FIGURE 1.

(2012) Robert I. Lehrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovering the Bacterial Circular Proteins: Bacteriocins, Cyanobactins, and Pilins

(2012) Manuel Montalbán-López et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hapivirins and Diprovirins: Novel  -Defensin Analogs with Potent Activity against Influenza A Virus

(2012) M. Doss et al.   JOURNAL OF IMMUNOLOGY

RTD-1Mimic Containing γPNA Scaffold Exhibits Broad-Spectrum Antibacterial Activities

(2012) Srinivas Rapireddy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recombinant production of rhesus θ-defensin-1 (RTD-1) using a bacterial expression system

(2012) Andrew Gould et al.   Molecular BioSystems

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Rhesus Macaque Theta Defensins Suppress Inflammatory Cytokines and Enhance Survival in Mouse Models of Bacteremic Sepsis

(2012) Justin B. Schaal et al.   PLoS One

PADLOC: A Powerful Tool to Assign Disulfide Bond Connectivities in Peptides and Proteins by NMR Spectroscopy

(2011) Leszek Poppe et al.   ANALYTICAL CHEMISTRY

Formulation Development of Retrocyclin 1 Analog RC-101 as an Anti-HIV Vaginal Microbicide Product

(2011) A. B. Sassi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Retrocyclins and their activity against HIV-1

(2011) W. Todd Penberthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Simplified θ-Defensins: Search for New Antivirals

(2011) Piotr Ruchala et al.   International Journal of Peptide Research and Therapeutics

Cycloquest: Identification of Cyclopeptides via Database Search of Their Mass Spectra against Genome Databases

(2011) Hosein Mohimani et al.   JOURNAL OF PROTEOME RESEARCH

Criterion for Amino Acid Composition of Defensins and Antimicrobial Peptides Based on Geometry of Membrane Destabilization

(2011) Nathan W. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

(2011) Joshua S Mylne et al.   Nature Chemical Biology

The biosynthesis of Caryophyllaceae-like cyclic peptides in Saponaria vaccaria L. from DNA-encoded precursors

(2011) Janet A. Condie et al.   PLANT JOURNAL

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria

(2010) Kaarina Sivonen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cyclotides, a promising molecular scaffold for peptide-based therapeutics

(2010) Krishnappa Jagadish et al.   BIOPOLYMERS

Defensins enable macrophages to inhibit the intracellular proliferation of Listeria monocytogenes

(2010) Eusondia Arnett et al.   CELLULAR MICROBIOLOGY

Bioactive Cyclic Peptides from Higher Plants

(2010) Hiroshi Morita et al.   HETEROCYCLES

Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities

(2010) Prasad Tongaonkar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cyclic and Acyclic Defensins Inhibit Human Immunodeficiency Virus Type-1 Replication by Different Mechanisms

(2010) Aprille Seidel et al.   PLoS One

De novosequencing of two new cyclicθ-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry

(2010) Christin Stegemann et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro

(2009) Qing-long Liang et al.   BIOTECHNOLOGY LETTERS

Cyclotides: macrocyclic peptides with applications in drug design and agriculture

(2009) David J. Craik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Substrate-Guided Design of a Potent and Selective Kallikrein-Related Peptidase Inhibitor for Kallikrein 4

(2009) Joakim E. Swedberg et al.   CHEMISTRY & BIOLOGY

Processing of the Phalloidin Proprotein by Prolyl Oligopeptidase from the MushroomConocybe albipes

(2009) Hong Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of  -,  -, and  -Defensins with Influenza A Virus and Surfactant Protein D

(2009) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Defensins in Viral Infections

(2009) Jian Ding et al.   Journal of Innate Immunity

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

(2009) C. L. Wohlford-Lenane et al.   JOURNAL OF VIROLOGY

Diverse backbone-cyclized peptides via codon reprogramming

(2009) Takashi Kawakami et al.   Nature Chemical Biology

Reawakening Retrocyclins: Ancestral Human Defensins Active Against HIV-1

(2009) Nitya Venkataraman et al.   PLOS BIOLOGY

Isolation, Synthesis, and Antimicrobial Activities of Naturally Occurring  -Defensin Isoforms from Baboon Leukocytes

(2008) A. E. Garcia et al.   INFECTION AND IMMUNITY

SDF2L1, a Component of the Endoplasmic Reticulum Chaperone Complex, Differentially Interacts with α-, β-, and θ-Defensin Propeptides

(2008) Prasad Tongaonkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RNA Polymerase II Trigger Loop Functions in Substrate Selection and Is Directly Targeted by α-Amanitin

(2008) Craig D. Kaplan et al.   MOLECULAR CELL

Unfolding the fold of cyclic cysteine-rich peptides

(2008) Amarda Shehu et al.   PROTEIN SCIENCE