Discovery of Selective Small-Molecule Activators of a Bacterial Glycoside Hydrolase

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology

(2012) Tracey M Gloster et al.   Nature Chemical Biology

Design of a Fragment Library that maximally represents available chemical space

(2011) M. N. Schulz et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Turning enzymes ON with small molecules

(2010) Julie A Zorn et al.   Nature Chemical Biology

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

(2010) Samantha Perez-Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GlcNAcstatins are nanomolar inhibitors of humanO-GlcNAcase inducing cellular hyper-O-GlcNAcylation

(2009) Helge C. Dorfmueller et al.   BIOCHEMICAL JOURNAL

Properties and identification of human protein drug targets

(2009) Tala M. Bakheet et al.   BIOINFORMATICS

Recent progress in fragment-based lead discovery

(2009) Michèle N Schulz et al.   CURRENT OPINION IN PHARMACOLOGY

Screening-based discovery of drug-likeO-GlcNAcase inhibitor scaffolds

(2009) Helge C. Dorfmueller et al.   FEBS LETTERS

Time efficient detection of protein–ligand interactions with the polarization optimized PO-WaterLOGSY NMR experiment

(2009) Alvar D. Gossert et al.   JOURNAL OF BIOMOLECULAR NMR

Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase

(2008) Yuan He et al.   CARBOHYDRATE RESEARCH