Discovery of Inhibitors of the Wnt and Hedgehog Signaling Pathways through the Catalytic Enantioselective Synthesis of an Iridoid-Inspired Compound Collection

Fulvenes as Effective Dipolarophiles in Copper(I)-Catalyzed [6+3] Cycloaddition of Azomethine Ylides: Asymmetric Construction of Piperidine Derivatives

(2013) Zhao-Lin He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Neuritogenic Compound Classes Inspired by Natural Products

(2013) Pierre-Yves Dakas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective synthesis of 4-aminopyrrolidine-2,4-dicarboxylate derivatives via Ag-catalyzed cycloaddition of azomethine ylides with alkylidene azlactones

(2013) María González-Esguevillas et al.   CHEMICAL COMMUNICATIONS

Highly Enantioselective Catalytic Synthesis of Neurite Growth-Promoting Secoyohimbanes

(2013) Andrey P. Antonchick et al.   CHEMISTRY & BIOLOGY

Cascade Syntheses Routes to the Centrocountins

(2013) Vincent Eschenbrenner-Lux et al.   CHEMISTRY-A EUROPEAN JOURNAL

Interplay of physics and evolution in the likely origin of protein biochemical function

(2013) Jeffrey Skolnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Natural Product Inspired Tetrahydropyran Collection Yields Mitosis Modulators that Synergistically Target CSE1L and Tubulin

(2012) Tobias Voigt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Homochiral Crystallization of Metal-Organic Silver Frameworks: Asymmetric [3+2] Cycloaddition of an Azomethine Ylide

(2012) Xu Jing et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Synthesis of α-Quaternary Proline Derivatives by 1,3-Dipolar Cycloaddition of α-Silylimines

(2012) Jorge Hernández-Toribio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Catalytic [6+3] Cycloadditions of Azomethine Ylides

(2012) Marco Potowski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potent small molecule Hedgehog agonists induce VEGF expression in vitro

(2012) Katrin Seifert et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Cu-catalyzed asymmetric [3+2] cycloaddition of α-iminoamides with activated olefins

(2012) María González-Esguevillas et al.   CHEMICAL COMMUNICATIONS

An Amine-Catalyzed Enantioselective [3+2] Cycloaddition of Azomethine Ylides and α,β-Unsaturated Aldehydes: Applications and Mechanistic Implications

(2012) Silvia Reboredo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Anti-Inflammatory Iridoids of Botanical Origin

(2012) A. Viljoen et al.   CURRENT MEDICINAL CHEMISTRY

Enantioselective Construction of Pyrrolidines by Palladium-Catalyzed Asymmetric [3 + 2] Cycloaddition of Trimethylenemethane with Imines

(2012) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable enantioselective one-pot synthesis of molecules with eight stereocenters

(2012) Marco Potowski et al.   Nature Chemical Biology

Densely substituted unnatural l- and d-prolines as catalysts for highly enantioselective stereodivergent (3 + 2) cycloadditions and aldol reactions

(2012) Egoitz Conde et al.   Chemical Science

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Naturally Occurring Iridoids and Secoiridoids. An Updated Review, Part 4

(2011) Biswanath Dinda et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Novel dipolarophiles and dipoles in the metal-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides

(2011) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Natural product–inspired cascade synthesis yields modulators of centrosome integrity

(2011) Heiko Dückert et al.   Nature Chemical Biology

A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model

(2011) Martin F. Strand et al.   PLoS One

Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

(2011) S. Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enantioselective synthesis of the spirotryprostatin A scaffold

(2011) Andrey P. Antonchick et al.   TETRAHEDRON

Bioactivity-Guided Navigation of Chemical Space

(2010) Robin S. Bon et al.   ACCOUNTS OF CHEMICAL RESEARCH

A 1,536-Well Ultra-High-Throughput siRNA Screen to Identify Regulators of the Wnt/β-Catenin Pathway

(2010) Namjin Chung et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Modulators of the hedgehog signaling pathway

(2010) Philipp Heretsch et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics

(2010) Stefan Peukert et al.   ChemMedChem

New developments in the discovery of small molecule Hedgehog pathway antagonists

(2010) Martin R Tremblay et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metal complexes versus organocatalysts in asymmetric 1,3-dipolar cycloadditions

(2010) Carmen Nájera et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

The Ras Pathway Modulator Melophlin A Targets Dynamins

(2009) Tanja Knoth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Natural Product Inspired Compound Collections

(2009) Kamal Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway

(2009) Anita Büttner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Naturally Occurring Iridoids, Secoiridoids and Their Bioactivity. An Updated Review, Part 3

(2009) Biswanath Dinda et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Small molecules for stem cells

(2009) Andrei Kochegarov   EXPERT OPINION ON THERAPEUTIC PATENTS

In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction

(2009) F. Osakada et al.   JOURNAL OF CELL SCIENCE

Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents

(2009) Neeraj Mahindroo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-molecule modulators of the Sonic Hedgehog signaling pathway

(2009) Benjamin Z. Stanton et al.   Molecular BioSystems

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Asymmetric Synthesis of Natural Product Inspired Tricyclic Benzopyrones by an Organocatalyzed Annulation Reaction

(2008) Herbert Waldmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effect of Wnt signaling pathway on wound healing

(2008) D.L. Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biology-inspired synthesis of compound libraries

(2008) M. Kaiser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Enantioselective Copper-Catalyzed 1,3-Dipolar Cycloadditions

(2008) Levi M. Stanley et al.   CHEMICAL REVIEWS

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural products in drug discovery

(2008) A HARVEY   DRUG DISCOVERY TODAY

Biological and Pharmacological Activities of Iridoids: Recent Developments

(2008) Rosa Tundis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Drug development from marine natural products

(2008) Tadeusz F. Molinski et al.   NATURE REVIEWS DRUG DISCOVERY

Directed Differentiation of Ventral Spinal Progenitors and Motor Neurons from Human Embryonic Stem Cells by Small Molecules

(2008) Xue-Jun Li et al.   STEM CELLS

β-Catenin in the race to fracture repair: in it to Wnt

(2008) David Silkstone et al.   Nature clinical practice. Rheumatology