Article
Biochemistry & Molecular Biology
Henry Struwe, Joern Droste, Dipendu Dhar, Mehdi D. Davari, Andreas Kirschning
Summary: A new FPP derivative with a shifted double bond has been discovered, which can be converted by sesquiterpene cyclases to form an unknown germacrene derivative. This finding sheds light on the cyclization mechanism of FPP.
Review
Chemistry, Organic
Hui-Jing Wang, Yang-Yang Zhong, You-Cai Xiao, Fen-Er Chen
Summary: This review summarizes the historical perspective and recent advances in the stereoselective synthesis of beta-nucleosides and their analogues, and introduces three synthetic strategies.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Pharmacology & Pharmacy
Sebastian C. Cosgrove, Gavin J. Miller
Summary: This article discusses the recent advances and challenges in using biocatalytic synthesis to access nucleoside analogues. It focuses on the methodology concepts of using enzymes to access diverse nucleoside analogue space and producing key building blocks, as well as the use of biocatalytic cascades for de novo syntheses of nucleoside analogue drugs. The article also mentions the recent advances in enzymatic nucleoside synthesis technologies, such as immobilization and flow, and highlights the need for tandem approaches across molecular microbiology and chemical synthesis to unlock the potential of next generation nucleoside analogue drug discovery.
EXPERT OPINION ON DRUG DISCOVERY
(2022)
Article
Chemistry, Applied
Yuan-Ting Cho, Avijit K. Adak, Yung-Yu Su, Ting-Wei Chang, Chun-Cheng Lin
Summary: In this study, a chemoenzymatic synthesis of the trisialoganglioside LLG-5 1 was accomplished, exhibiting neuritogenic activity. A photoactivatable lactosyl phytosphingosine was developed to enable solubility in enzymatic reactions. This synthetic strategy may be applicable for the synthesis of other gangliosides.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Harbansh Singla, Sandeep Kumar, Jyotirmoy Maity, Ashok K. Prasad
Summary: A greener chemo-enzymatic methodology has been developed for synthesizing conformationally restricted diastereomeric AZT analogues. The primary hydroxyl group of 3'-azido-3'-deoxy-beta-D-glucofuranosyl pyrimidines was acetylated using Novozyme (R) 435, and then converted to the desired bicyclic AZT analogue.
CARBOHYDRATE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zeshi Li, Luca Unione, Lin Liu, Yifei Lang, Robert P. de Vries, Raoul J. de Groot, Geert-Jan Boons
Summary: O-acetylation of sialic acids plays a role in various coronaviruses and influenza viruses, but different viruses exhibit distinct requirements for O-acetylation, and ester-to-amide perturbation can result in decreased or loss of binding. Molecular modeling studies suggest that binding specificity is governed by the complementarity between acetyl moieties of sialosides and hydrophobic patches of the lectin.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Sandeep Kumar, Jyotirmoy Maity, Banty Kumar, Sumit Kumar, Ashok K. Prasad
Summary: Conformationally restricted diastereomeric homoarabinofuranosylpyrimidines (AZT analogue) were synthesized using chemoenzymatic and chemical routes. The chemoenzymatic method showed superiority in terms of synthetic steps and overall yield.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tuan-Anh M. Nguyen, Trinh-Don Nguyen, Yuen Yee Leung, Matthew McConnachie, Oleg Sannikov, Zhicheng Xia, Thu-Thuy T. Dang
Summary: This study identified two cytochrome P450 monooxygenases in Camptotheca acuminata that can oxidize camptothecin to produce potent anticancer drugs. The discovery sheds new light on camptothecin metabolism and offers greener approaches for synthesizing clinically relevant derivatives.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Chemistry, Organic
Rajendra S. Rohokale, Qingjiang Li, Zhongwu Guo
Summary: The synthetic strategy utilizing a single starting material and stepwise elongation of the glycan, as well as on-site remodeling of the lipid, successfully synthesized GSL compounds with different functionalities and sugar chains.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Multidisciplinary Sciences
Dake Liu, Garret M. Rubin, Dipesh Dhakal, Manyun Chen, Yousong Ding
Summary: Peptidic natural products (PNPs) serve as a valuable source of lead compounds for drug discovery, but their chemical synthesis faces challenges such as the unavailability of constituent amino acids. Advances in biosynthesis and biocatalysis offer a promising alternative for the synthesis of PNPs.
Article
Chemistry, Organic
Hai Yu, Zimin Zheng, Libo Zhang, Xiaohong Yang, Ajit Varki, Xi Chen
Summary: The stable N-acetyl analogues of biologically important 9-O-acetylated b-series gangliosides have been synthesized from a GM3 sphingosine using chemoenzymatic methods. Two chemoenzymatic methods were compared, and the second method was found to be more efficient for synthesizing 9NAc-GD3. Acylation reaction conditions were also improved to obtain target 9-N-acetylated gangliosides in a faster reaction with an easier purification process.
Article
Biochemistry & Molecular Biology
Eva S. Schoenegger, Antony Crisp, Marco Radukic, Jonas Burmester, Thomas Frischmuth, Thomas Carell
Summary: Post-synthetic modification of nucleic acid structures with clickable functionality is a versatile tool that improves the performance and applicability of nucleic acids. This study presents a simple and feasible technology to modify DNA and RNA strands at both ends. This method helps to synthesize highly functionalized oligonucleotides, enhancing their therapeutic and diagnostic applications.
Article
Biochemistry & Molecular Biology
Bing-Mei Su, Yi-Bing Shi, Wei Lin, Lian Xu, Xin-Qi Xu, Juan Lin
Summary: A novel chemo-enzymatic process was developed to produce highly purified DHEA, an important neurosteroid hormone, in the pharmaceutical industry.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Amanda J. Reid, Katelyn M. Erickson, Joseph M. Hazel, Vinita Lukose, Jerry M. Troutman
Summary: Complex poly-and oligosaccharides on bacteria's surface can be used for the development of therapeutics or sensors that are selective for specific glycans. The addition of a chemically functional benzylazide tag to polyisoprenoids enables the chemoenzymatic preparation and immobilization of bacterial glycans. This method has been demonstrated to assemble Campylobacter jejuni N-linked heptasaccharide and immobilize it on magnetic beads, showing potential for the discovery of new glycan-interacting partners.
Article
Chemistry, Organic
Beata Zdun, Tamara Reiter, Wolfgang Kroutil, Pawel Borowiecki
Summary: We developed chemoenzymatic routes using low-cost starting materials and enzyme preparations to synthesize tenofovir. The key step involved stereoselective reduction or kinetic resolution using alcohol dehydrogenase or lipase as biocatalysts. By employing immobilized lipase in a mixture of vinyl acetate and toluene, the desired (R)-ester was obtained with high yield and optical purity. Alternatively, reduction of a ketone using lyophilized E. coli cells containing recombinant alcohol dehydrogenase resulted in excellent conversion and yield of the corresponding (R)-alcohol. The enzymatic strategy could be applied in the synthesis of tenofovir prodrug derivatives.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Melissa Salmon, Caroline Laurendon, Maria Vardakou, Jitender Cheema, Marianne Defernez, Sol Green, Juan A. Faraldos, Paul E. O'Maille
NATURE COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Trinh-Don Nguyen, Juan A. Faraldos, Maria Vardakou, Melissa Salmon, Paul E. O'Maille, Dae-Kyun Ro
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
Mengbin Chen, Wayne K. W. Chou, Naeemah Al-Lami, Juan A. Faraldos, Rudolf K. Allemann, David E. Cane, David W. Christianson
Review
Biochemistry & Molecular Biology
Jitender Cheema, Juan A. Faraldos, Paul E. O'Maille
Article
Biochemistry & Molecular Biology
Jian-Xu Li, Xin Fang, Qin Zhao, Ju-Xin Ruan, Chang-Qing Yang, Ling-Jian Wang, David J. Miller, Juan A. Faraldos, Rudolf K. Allemann, Xiao-Ya Chen, Peng Zhang
BIOCHEMICAL JOURNAL
(2013)
Article
Biochemistry & Molecular Biology
Mengbin Chen, Naeemah Al-lami, Marine Janvier, Edward L. D'Antonio, Juan A. Faraldos, David E. Cane, Rudolf K. Allemann, David W. Christianson
Article
Chemistry, Multidisciplinary
Zulfa Yoosuf-Aly, Juan A. Faraldos, David J. Miller, Rudolf K. Allemann
CHEMICAL COMMUNICATIONS
(2012)
Article
Chemistry, Organic
Juan A. Faraldos, Robert M. Coates, Jose-Luis Giner
JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Chemistry, Multidisciplinary
Juan A. Faraldos, David J. Miller, Veronica Gonzalez, Zulfa Yoosuf-Aly, Oscar Cascon, Amang Li, Rudolf K. Allemann
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Article
Chemistry, Multidisciplinary
Juan A. Faraldos, Veronica Gonzalez, Amang Li, Fanglei Yu, Mustafa Koeksal, David W. Christianson, Rudolf K. Allemann
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Article
Chemistry, Multidisciplinary
Veronica Gonzalez, Sabrina Touchet, Daniel J. Grundy, Juan A. Faraldos, Rudolf K. Allemann
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Article
Multidisciplinary Sciences
Artemis Giannakopoulou, Sebastian Schornack, Tolga O. Bozkurt, Dave Haart, Dae-Kyun Ro, Juan A. Faraldos, Sophien Kamoun, Paul E. O'Maille
Article
Chemistry, Multidisciplinary
Melodi Demiray, Xiaoping Tang, Thomas Wirth, Juan A. Faraldos, Rudolf K. Allemann
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Multidisciplinary Sciences
Maria Vardakou, Melissa Salmon, Juan A. Faraldos, Paul E. O'Maille
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
