β-Secretase Inhibitor Potency Is Decreased by Aberrant β-Cleavage Location of the “Swedish Mutant” Amyloid Precursor Protein

Reduction of SorLA/LR11, a Sorting Protein Limiting β-Amyloid Production, in Alzheimer Disease Cerebrospinal Fluid

(2009) Qiu-Lan Ma et al.   ARCHIVES OF NEUROLOGY

Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1

(2009) Shawn J. Stachel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Upregulation of BACE1 and β-Amyloid Protein Mediated by Chronic Cerebral Hypoperfusion Contributes to Cognitive Impairment and Pathogenesis of Alzheimer’s Disease

(2009) Cai Zhiyou et al.   NEUROCHEMICAL RESEARCH

Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by α- and γ-secretase

(2008) Keita Takahashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid   Reduction by  -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice

(2008) J. E. Meredith et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

First Demonstration of Cerebrospinal Fluid and Plasma A  Lowering with Oral Administration of a  -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

(2008) S. Sankaranarayanan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

(2008) Maria-Paz Marzolo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY