Article
Chemistry, Analytical
Yingying Chen, Ying He, Jinwen Zhao, Jin Zhang, Ruo Yuan, Shihong Chen
Summary: This study developed a novel hydrophobic localized enrichment strategy using beta-cyclodextrin (beta-CD) to improve the sensitivity of electrochemiluminescence (ECL) detection. The biosensor constructed with TDBA-beta-CD-Pt nanocomposite and PDP PNPs achieved highly sensitive detection of ncovNP. This research provides a promising and sensitive ECL platform for ncovNP detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chen Chen, Jin-Xin Ma, Hui Wang, Hui-Qiao Liu, Shu-Wei Ren, Jun-Tao Cao, Yan-Ming Liu
Summary: A spatially resolved ratiometric electrochemiluminescence immunosensor was developed for myoglobin detection, using resonance energy transfer for signal amplification. The sensor exhibited high selectivity, sensitivity, and accuracy, making it a promising tool for biomarker analysis.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Analytical
Olga A. Goryacheva, Natalia Beloglazova, Irina Yu Goryacheva, Sarah De Saeger
Summary: Semiconductor quantum dots (QDs) are widely used as luminescent labels in food and medical analysis, and in combination with gold nanoparticles (GNs) as energy acceptors in Forster resonance energy transfer (FRET) pairs to develop highly sensitive biosensors. The developed homogeneous FRET-based immunoassay for detecting deoxynivalenol (DON) demonstrates the potential of fast and high-throughput mycotoxin control with a low limit of detection.
Review
Chemistry, Physical
Yemataw Addis Alemu, Enrico Rampazzo, Francesco Paolucci, Luca Prodi, Giovanni Valenti
Summary: Nanomaterials play an important role in enhancing the analytical performance of electrochemiluminescence by modifying the photophysical properties of the excited state through processes like metal-enhanced fluorescence and resonance energy transfer.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2022)
Article
Chemistry, Analytical
Zhanglei Wu, Shanghua Liu, Yueyuan Li, Feng Tang, Zengdian Zhao, Qing Liu, Yueyun Li, Qin Wei
Summary: This study proposed a novel ECL-based biosensor using gold nanoclusters coupled with graphene quantum dots as signal labels, supported on well-ordered Co3O4 nanoarrays as the sensing substrate. The biosensor showed good ECL response for detecting cardiac troponin I, with a satisfactory linear range and ultra-low detection limit. The rational design of this biosensor provides a clue for enhancing the ECL-RET model.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Zihui Liang, Yixin Nie, Xin Zhang, Peilin Wang, Qiang Ma
Summary: A novel multiplex electrochemiluminescence polarization assay was developed to detect breast cancer-related genes BRCA1 and BRCA2 simultaneously. The study revealed the relation between the structure of metal nanomaterials and SPC-ECL, and a high polarization-resolved sensing system was designed to detect multitarget DNA. Polarization-based multiple ECL analysis has broad prospects in related cancer diagnosis and treatment evaluation.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Shuangtian Dong, Dongyang Wang, Xuwen Gao, Li Fu, Jingna Jia, Yuqi Xu, Bin Zhang, Guizheng Zou
Summary: This study proposes a method to achieve chemiluminescence with different wavelengths and intensities by adjusting triggering agents, which shows promising potential for applications in immunoassays and other fields.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiang Hu, Ying Wang, Xiong Zuping, Pei Song, Ai-Jun Wang, Zhaosheng Qian, Pei-Xin Yuan, Tiejun Zhao, Jiu-Ju Feng
Summary: In this study, an aggregation-enhanced PEC photosensitizer PPIX-[BMIm] was prepared by electrostatic bonding, and its PEC performance in a binary solvent of water and DMSO was studied. A label-free PEC cytosensor was built using PPIX-[BMIm], which showed a wide linear range and low limit of detection for detecting leukemia cells.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Hui Sun, Ping Zhou, Bin Su
Summary: Electrochemiluminescence (ECL) is chemiluminescence that is triggered by electrochemical reactions. ECL has become a powerful analytical technique widely used in biosensing and imaging due to its unique excitation mode and low background. Semiconductor quantum dots (QDs), as emerging ECL luminophores, have significant advantages over traditional molecular luminophores in terms of luminescence efficiency and signal modulation ability. Therefore, the development of an efficient ECL system using QDs as luminophores is important for improving the sensitivity and detection flux of ECL biosensors.
Article
Chemistry, Analytical
Ali Firoozbakhtian, Morteza Hosseini, Mahsa Naghavi Sheikholeslami, Foad Salehnia, Guobao Xu, Hodjattallah Rabbani, Ebtesam Sobhanie
Summary: The rapid spread of SARS-CoV-2 has raised the need for efficient and rapid diagnostic tools. In this study, an electrochemiluminescence (ECL)-based detection system was developed and trained using machine learning algorithms to accurately diagnose COVID-19 with over 90% accuracy. The system provides a cost-effective and time-saving alternative to traditional testing methods.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Li Wang, Wei-Jia Zeng, Xia Yang, Ruo Yuan, Wen-Bin Liang, Ying Zhuo
Summary: In this work, luminescent groups rich carbon dots (Lu-CDs) were synthesized by incorporating luminol into the CDs, resulting in a significantly enhanced electrochemiluminescent (ECL) performance. The ECL emission of Lu-CDs showed excellent consistency with its fluorescence emission, unlike other surface state-dominated CDs. Furthermore, Lu-CDs were used to develop an ECL biosensor for tumor cell analysis, demonstrating a wide detection range and low detection limit.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jiajia Wang, Xin Hua, Baokang Jin
Summary: A facile in situ fabrication method for chitosan/polythiophene/CdTe nanocomposite was developed and connected with anti-CEA for electrochemical detection of carcinoembryonic antigen. The resulting nanocomposite showed high selectivity and excellent sensitivity, with a potential application in clinical tumor detection.
Article
Chemistry, Analytical
Hongmin Gao, Ze Zhang, Yingcong Zhang, Hongwei Yu, Shengzhong Rong, Lingqiang Meng, Shizhen Song, Yong Mei, Hongzhi Pan, Dong Chang
Summary: Resonance energy transfer (RET) is a widely used strategy for exploring biological processes and achieving sensitive bioanalysis. A sensitive immunosensor was constructed for detecting cancer antigen 125 (CA125) using RET between graphitic carbon nitride (g-C3N4) and NIR CdTe/CdS QDs, showing excellent analytical performance and stability.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Shenglan Hu, Dongmiao Qin, Shuo Meng, Yusheng Wu, Zhi Luo, Biyang Deng
Summary: An ultrasensitive electrochemiluminescence (ECL) sensor using sulfur quantum dots (SQDs) as the luminophore was developed for the determination of dopamine. The proposed method exhibits excellent specificity, low detection limit, and high sensitivity, making it applicable in the analysis of real samples and the improvement of human health.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Siobhan O'Connor, Lynn Dennany, Emmet O'Reilly
Summary: This review focuses on the innovations and applications of low toxicity semi-conductor quantum dots (SCQDs) utilised as ECL luminophores within biosensors. These materials have the advantages of tunable emission, low toxicity, and good water dispersibility. The review also explores the functionalization and multiplexing potential of these materials.
BIOELECTROCHEMISTRY
(2023)
