Article
Polymer Science
Jiahao Shi, Zhengnan Lu, Yan Pan, Yang Sheng, Yixin Sun, Linhong Deng, Mark Bradley, Le Zhou, Rong Zhang
Summary: In this study, water-soluble derivatives of PpIX were synthesized, overcoming the poor solubility of PpIX and achieving high levels of antibacterial killing and cytotoxicity. This has significant implications for the application of photodynamic therapy in antibacterial and anticancer treatment.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Mengqing Jiang, Yihua Yin, Weiquan Cai, Jingli Zhang, Lihong Fan, Yue Dai, Ting Zhou, Jinsheng Liu
Summary: A new strategy combining photodynamic insecticide action and stimulus-responsive polymer micelles has been developed to improve photostability, enhance utilization rate, and reduce pest resistance. The strategy involves the preparation of PBA-modified mPEG conjugate followed by self-assembly to obtain polymeric nanoparticles, which show stability in water but can change structure in response to UV light and/or esterase stimulation. The nanoparticles effectively inhibit the photodegradation of PpIX and exhibit higher phototoxicity to insect cells compared to free PpIX. UV light and/or esterase stimulus can trigger PpIX release, resulting in high photodynamic activity.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Beata Joanna Mossakowska, Somayeh Shahmoradi Ghahe, Dominik Cysewski, Anna Fabisiewicz, Barbara Tudek, Janusz Aleksander Siedlecki
Summary: Photodynamic therapy (PDT) is a valuable treatment method for vulvar intraepithelial neoplasia (VIN) as it allows for minimal tissue destruction and treatment of multifocal disease. However, resistance to PDT in vulvar cancer may be due to alterations in the heme synthesis pathway and increased activity of the DNA repair protein APE1. Inhibition of APE1 activity may enhance the efficacy of PDT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mariana C. S. Vallejo, Nuno M. M. Moura, Ana T. P. C. Gomes, Ana S. M. Joaquinito, Maria Amparo F. Faustino, Adelaide Almeida, Idalina Goncalves, Vanda Vaz Serra, Maria Graca P. M. S. Neves
Summary: Microorganisms in skin wounds can cause infections, but photodynamic therapy using porphyrinoids as photosensitizers can effectively eradicate them and promote wound healing. Porphyrinoids have the ability to generate reactive oxygen species, which not only prevent infections but also promote cell proliferation and regulate inflammation factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
D. C. K. Codognato, F. S. Pena, E. R. Dos Reis, A. P. Ramos, I. E. Borissevitch
Summary: The interaction between synthetic protoporphyrin IX and protoporphyrin IX extracted from Harderian glands of ssp Rattus novergicus albinus rats with bovine serum albumin was studied. The aggregation and binding properties of protoporphyrin IX were found to be influenced by pH. Protoporphyrin IX has potential applications as a fluorescence probe and photosensitizer.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Brittany P. Rickard, Xianming Tan, Suzanne E. Fenton, Imran Rizvi
Summary: This study demonstrates for the first time that photodynamic priming (PDP) can overcome PFAS-induced platinum resistance in ovarian cancer cells. PDP modulates mitochondrial membrane potential, reducing it and re-sensitizing ovarian cancer cells to platinum-based chemotherapy.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Andrey V. Kustov, Mikhail A. Krestyaninov, Sergey O. Kruchin, Olga V. Shukhto, Tatyana V. Kustova, Dmitry V. Belykh, Irina S. Khudyaeva, Mikhail O. Koifman, Pavel B. Razgovorov, Dmitry B. Berezin
Summary: The study showed that cationic chlorophyll photosensitizers interact with non-ionic surfactant Tween 80 to form stable molecular complexes, with the PS molecules located at the periphery of surfactant micelles. Additionally, the interaction strength between PS and surfactant increases with the charge of the macrocyclic cation.
MENDELEEV COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Zuping Xiong, Wenqi Gong, Pengfei Xu, Mengyi Jiang, Xuting Cai, Yuqing Zhu, Xinni Ping, Hui Feng, Huili Ma, Zhaosheng Qian
Summary: This study re-examined the classic heavy-atom effect from a completely fresh perspective and proposed a universal heavy-atom-induced fluorescence enhancement principle suited for most AIEgens.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Shixuan An, Yanfei Lin, Jianbo Wang, Tianqing Ye, Yanyun Mao, Jian Zhang, Longhua Guo, Lei Li, Zhaosheng Qian, Haiying Liu
Summary: In this study, a novel near-infrared fluorescent probe was designed and developed for the detection and fluorescence imaging of cysteine/homocysteine. The probe exhibited rapid response and high sensitivity, with a detection limit of 46 nM for cysteine. Additionally, the probe could be employed for imaging and detection in living cells and in vivo.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Organic
Yuqing Zhu, Yangbing Chen, Zuping Xiong, Mengyi Jiang, Hui Feng, Zhaosheng Qian
Summary: In this study, photoresponsive functions such as photochromism were successfully incorporated into aggregation-induced emission (AIE) molecules through a simple and low-cost strategy. A series of C3-symmetric molecules with aggregation-induced emission and base-gated photochromism were synthesized, showing excellent photophysical characteristics in solid-state. The base-gated photochromism of these molecules, constructed by low-cost benzene rings, can detect toxic organic bases, attributed to the multicyano-sensitized benzene rings of these AIE luminogens.
Article
Chemistry, Analytical
Ke-Yi Shen, Jiale Zhan, Luan Shen, Zuping Xiong, Hao-Tian Zhu, Ai-Jun Wang, Pei-Xin Yuan, Jiu-Ju Feng
Summary: In this study, HOFs were formed by self-assembly of TATB and linked with ILu via amide bond to improve the ECL efficiency. The ILu-HOFs NH2-ITO showed a 23.4-fold increase in ECL efficiency compared to ILu alone. A sandwich ECL biosensor was then constructed for the detection of ICP, achieving a broad linear range and low LOD, and successfully detecting ICP in environmental samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ziteng Zhang, Jianyu Zhang, Zuping Xiong, Bo Chu, Chengjian Zhang, Jing Zhi Sun, Haoke Zhang, Xing-Hong Zhang, Ben Zhong Tang
Summary: This work presents the design and synthesis of six phenolic resins with clusteroluminescence (CL) property. By increasing the number of through-space interactions (TSIs) units and introducing electron-donating/-withdrawing groups, these non-conjugated polymers achieve near-infrared (NIR) emission with high absolute quantum yield. Through experiments and theoretical analysis, the crucial roles of through-space locally excited state and through-space charge transfer state in achieving CL from non-conjugated polymers are revealed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Zuping Xiong, Jianyu Zhang, Lei Wang, Yuan Xie, Yipu Wang, Zujin Zhao, Haoke Zhang, Jing Zhi Sun, Feihe Huang, Ben Zhong Tang
Summary: Nonconjugated clusteroluminogens (CLgens), such as proteins and polystyrene, have become increasingly important in photophysics due to their advantages over traditional conjugated dyes in biological applications. However, their weak visible emissions in the aggregate state have hindered their development. This study proposes a strategy to construct a higher-level intramolecular through-space interaction (TSI) in multi-aryl-substituted alkanes, resulting in efficient clusteroluminescence (CL) with high luminescence quantum yield and long emission wavelength.
Article
Biophysics
Xiang Hu, Xiajunpeng Wu, Zuping Xiong, Xin-Tao Wang, Ai-Jun Wang, Pei-Xin Yuan, Tiejun Zhao, Jiu-Ju Feng
Summary: In this study, the PEC responses were enhanced by about 4.3-fold through in situ electrostatic assembly of [BIm][BF4] on TP-NH2-ITO. Furthermore, [BIm](+)-TP-NH2-ITO exhibited a much larger photocurrent in a water/DMSO binary solvent with a water fraction of 90%, showing a 6.7-fold increase compared to pure DMSO. The PEC detection strategy based on the in situ assembly of [BIm](+)--TP-NH2-ITO and the competitive reaction between magnetic bead linked dsDNA and HCT-116 cells achieved single-cell bioanalysis and early diagnosis of tumors.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Xinni Ping, Jiale Zhan, Yuqing Zhu, Yuzhen Wu, Caiyi Hu, Junjun Pan, Chuangye Yao, Jiaqi Zuo, Hui Feng, Zhaosheng Qian
Summary: Here we report the efficient photoactivation of bright solid-state fluorescence based on controllable intermolecular [2+2] photodimerization reaction of BTO derivatives, providing a simple and effective way to construct smart photoresponsive solid-state fluorescent materials.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Materials Science, Multidisciplinary
Xinni Ping, Junjun Pan, Xin Peng, Chuangye Yao, Tian Li, Hui Feng, Zhaosheng Qian
Summary: The development of light responsive fluorescent materials with nondestructive and high-contrast signaling properties has attracted much attention. Recent advances in intermolecular [2+2] photocycloaddition reactions have led to the construction of a new class of light responsive fluorescent materials with enhanced solid-state fluorescence. This review summarizes the recent advances in structural design, controlled molecular aggregation, and distinct photoactivation mechanisms of these smart materials, and discusses the challenges and opportunities for future development.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Physical
Yuqing Zhu, Xinni Ping, Xiangting Wang, Xuting Cai, Jiaqi Zuo, Zhaosheng Qian, Hui Feng
Summary: This study proposes a molecular design strategy to achieve fluoride-regulated colorimetric and fluorometric switches based on B-F dynamic covalent reactions. By introducing borate units into AIE-active molecular skeletons, a group of fluoride-responsive smart molecules were designed with sharp color and fluorescence changes. These molecules show high sensitivity and selectivity for fluoride ions in solution and on solid matrices, making them ideal for diverse practical applications.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Chemistry, Analytical
Shu-Shu Song, Jiale Zhan, Hao-Tian Zhu, Jing-Yi Bao, Ai-Jun Wang, Pei-Xin Yuan, Jiu-Ju Feng
Summary: This study investigates the use of palladium nanospheres-embedded metal-organic frameworks to enhance the electrochemiluminescence efficiency of organic emitters in aqueous solutions, leading to the development of a highly efficient electrochemiluminescence sensor.
Review
Materials Science, Multidisciplinary
Yuzhen Wu, Yuqing Zhu, Chuangye Yao, Jiale Zhan, Penglei Wu, Zhengdong Han, Jiaqi Zuo, Hui Feng, Zhaosheng Qian
Summary: Photochromic materials are widely used due to their excellent properties, and molecular materials that use fluorescence as a readout signal exhibit superior sensitivity and accuracy. Integrating photoluminescence into photochromic molecules is an increasing trend, achieving dual-channel signal response and improving sensitivity.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
