EZH2 in Bladder Cancer, a Promising Therapeutic Target

SAH derived potent and selective EZH2 inhibitors

(2015) Pei-Pei Kung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression

(2015) Xianghong Ning et al.   CANCER LETTERS

Abstract 3508: Inhibition of EZH2 overcomes resistance to sunitinib in clear cell renal cell carcinoma models

(2015) Remi M. Adelaiye-Ogala et al.   CANCER RESEARCH

Downregulation of urinary cell-free microRNA-214 as a diagnostic and prognostic biomarker in bladder cancer

(2015) Jinfeng Wang et al.   JOURNAL OF SURGICAL ONCOLOGY

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)

(2015) Xia Jiang et al.   PLoS One

EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity

(2015) John E. Campbell et al.   ACS Medicinal Chemistry Letters

A Polycomb-mir200 loop regulates clinical outcome in bladder cancer

(2015) Mónica Martínez-Fernández et al.   Oncotarget

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression

(2015) Nienke A. de Vries et al.   Cell Reports

Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer

(2015) Mónica Martínez-Fernández et al.   Clinical Epigenetics

Abstract 1697: CPI-169, a novel and potent EZH2 inhibitor, synergizes with CHOPin vivoand achieves complete regression in lymphoma xenograft models

(2015) Vidya Balasubramanian et al.   CANCER RESEARCH

Inhibition of Methyltransferases Accelerates Degradation of cFLIP and Sensitizes B-Cell Lymphoma Cells to TRAIL-Induced Apoptosis

(2015) Frank K. Braun et al.   PLoS One

Myc Enforces Overexpression of EZH2 in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms

(2015) Cheryl M. Koh et al.   Oncotarget

Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo

(2015) Shou-Hung Tang et al.   Oncotarget

Biological determinants of bladder cancer gene expression subtypes

(2015) Mattias Aine et al.   Scientific Reports

High protein expression of EZH2 is related to unfavorable outcome to tamoxifen in metastatic breast cancer

(2014) E. A. Reijm et al.   ANNALS OF ONCOLOGY

Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer

(2014) M. T. W. Teo et al.   ANNALS OF ONCOLOGY

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

(2014) B. Xu et al.   BLOOD

Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

(2014) Woonyoung Choi et al.   CANCER CELL

In Vivo Disruption of an Rb-E2F-Ezh2 Signaling Loop Causes Bladder Cancer

(2014) M. Santos et al.   CANCER RESEARCH

EZH2 Inhibitor Efficacy in Non-Hodgkin’s Lymphoma Does Not Require Suppression of H3K27 Monomethylation

(2014) William D. Bradley et al.   CHEMISTRY & BIOLOGY

Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer

(2014) M. L. Nickerson et al.   CLINICAL CANCER RESEARCH

Histone methylases as novel drug targets: developing inhibitors of EZH2

(2014) Catherine Baugé et al.   Future Medicinal Chemistry

Targeting histone methyltransferase EZH2 as cancer treatment

(2014) Y. Kondo   JOURNAL OF BIOCHEMISTRY

MicroRNA miR-124 Controls the Choice between Neuronal and Astrocyte Differentiation by Fine-tuning Ezh2 Expression

(2014) Wen Hao Neo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment

(2014) Maria Lehmann et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

miR-200c Inhibits invasion, migration and proliferation of bladder cancer cells through down-regulation of BMI-1 and E2F3

(2014) Lei Liu et al.   Journal of Translational Medicine

microRNA-124 inhibits proliferation and induces apoptosis by directly repressing EZH2 in gastric cancer

(2014) Liming Xie et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Polycomb Repressive Complex 2 and H3K27me3 Cooperate with H3K9 Methylation To Maintain Heterochromatin Protein 1  at Chromatin

(2014) J. Boros et al.   MOLECULAR AND CELLULAR BIOLOGY

Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer

(2014) Ming-zhe Ma et al.   Molecular Cancer

EZH2: Not EZHY (Easy) to Deal

(2014) Gauri Deb et al.   MOLECULAR CANCER RESEARCH

Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma

(2014) S. K. Knutson et al.   MOLECULAR CANCER THERAPEUTICS

Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells

(2014) Yan Zhuang et al.   MOLECULAR CARCINOGENESIS

The Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing

(2014) Chiara Mozzetta et al.   MOLECULAR CELL

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

The mechanism of action of BCG therapy for bladder cancer—a current perspective

(2014) Gil Redelman-Sidi et al.   Nature Reviews Urology

MicroRNA-137 Upregulation Increases Bladder Cancer Cell Proliferation and Invasion by Targeting PAQR3

(2014) Youcheng Xiu et al.   PLoS One

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

(2014) J. S. Damrauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high level of circulating HOTAIR is associated with progression and poor prognosis of cervical cancer

(2014) Jing Li et al.   TUMOR BIOLOGY

Polycomb protein EZH2 suppresses apoptosis by silencing the proapoptotic miR-31

(2014) Q Zhang et al.   Cell Death & Disease

Regulation and Role of EZH2 in Cancer

(2014) Hirohito Yamaguchi et al.   Cancer Research and Treatment

UNEXPECTED URINARY SCHISTOSOMA INFECTION IN A BELGIAN TRAVEL GROUP RETURNING FROM MALAWI

(2014) M Oyaert et al.   ACTA CLINICA BELGICA

Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells

(2014) S Hibino et al.   Oncogenesis

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

(2013) Kyle D. Konze et al.   ACS Chemical Biology

EZH2: biology, disease and structure-based drug discovery

(2013) Jin-zhi Tan et al.   ACTA PHARMACOLOGICA SINICA

linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer

(2013) Wang He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity

(2013) J. Yan et al.   BLOOD

Recent advances in the diagnosis and treatment of bladder cancer

(2013) Grace Cheung et al.   BMC Medicine

Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101

(2013) Yongjun Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

EZH2 participates in malignant biological behavior of epithelial ovarian cancer through regulating the expression of BRCA1

(2013) Tao Li et al.   CANCER BIOLOGY & THERAPY

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression

(2013) Ming Luo et al.   CANCER LETTERS

Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition

(2013) Michael Amatangelo et al.   CELL CYCLE

MiR-138 Inhibits Tumor Growth Through Repression of EZH2 in Non-Small Cell Lung Cancer

(2013) Huijun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Identification of EZH2 and EZH1 Small Molecule Inhibitors with Selective Impact on Diffuse Large B Cell Lymphoma Cell Growth

(2013) Shivani Garapaty-Rao et al.   CHEMISTRY & BIOLOGY

Histone Lysine-Specific Methyltransferases and Demethylases in Carcinogenesis: New Targets for Cancer Therapy and Prevention

(2013) Xuejiao Tian et al.   CURRENT CANCER DRUG TARGETS

miR-144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling

(2013) Yuwen Guo et al.   FEBS Journal

c-Myc-mediated epigenetic silencing of MicroRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma

(2013) Lei Wang et al.   HEPATOLOGY

Large Intervening Non-Coding RNA HOTAIR is Associated with Hepatocellular Carcinoma Progression

(2013) YJ Geng et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1

(2013) Xianglai Xu et al.   Journal of Translational Medicine

Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy

(2013) Jeffrey S Ross et al.   MODERN PATHOLOGY

Cdyl, a New Partner of the Inactive X Chromosome and Potential Reader of H3K27me3 and H3K9me2

(2013) M. Escamilla-Del-Arenal et al.   MOLECULAR AND CELLULAR BIOLOGY

PIK3CAgene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors

(2013) Marta Dueñas et al.   MOLECULAR CARCINOGENESIS

Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth

(2013) Tai-Lung Cha et al.   MOLECULAR CARCINOGENESIS

PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation

(2013) Hae-Yun Jung et al.   MOLECULAR CELL

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer

(2013) Woojin Kim et al.   Nature Chemical Biology

Inhibition of GSK 3β Activity Is Associated with Excessive EZH2 Expression and Enhanced Tumour Invasion in Nasopharyngeal Carcinoma

(2013) Renqiang Ma et al.   PLoS One

Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression

(2013) Adrienne Grzenda et al.   Epigenetics & Chromatin

Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression

(2013) Lingjie Li et al.   Cell Reports

EZH2, an epigenetic driver of prostate cancer

(2013) Yeqing Angela Yang et al.   Protein & Cell

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Stat3 Activation in Urothelial Stem Cells Leads to Direct Progression to Invasive Bladder Cancer

(2012) P. L. Ho et al.   CANCER RESEARCH

MYC Acts via the PTEN Tumor Suppressor to Elicit Autoregulation and Genome-Wide Gene Repression by Activation of the Ezh2 Methyltransferase

(2012) M. Kaur et al.   CANCER RESEARCH

Asymmetrically Modified Nucleosomes

(2012) Philipp Voigt et al.   CELL

TP53 Genomic Status Regulates Sensitivity of Gastric Cancer Cells to the Histone Methylation Inhibitor 3-Deazaneplanocin A (DZNep)

(2012) L. L. Cheng et al.   CLINICAL CANCER RESEARCH

A Molecular Taxonomy for Urothelial Carcinoma

(2012) G. Sjodahl et al.   CLINICAL CANCER RESEARCH

G9a, a multipotent regulator of gene expression

(2012) Shilpa Rani Shankar et al.   Epigenetics

Multifocal Carcinoma In Situ of the Upper Tract Is Associated With High Risk of Bladder Cancer Recurrence

(2012) Evanguelos Xylinas et al.   EUROPEAN UROLOGY

Epidemiology and Risk Factors of Urothelial Bladder Cancer

(2012) Maximilian Burger et al.   EUROPEAN UROLOGY

PRC2 directly methylates GATA4 and represses its transcriptional activity

(2012) A. He et al.   GENES & DEVELOPMENT

Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis

(2012) Sandy Leung-Kuen Au et al.   HEPATOLOGY

Non-coding RNAs and EZH2 interactions in cancer: Long and short tales from the transcriptome

(2012) Leonidas Benetatos et al.   INTERNATIONAL JOURNAL OF CANCER

Down-Regulation of the miR-25 and miR-30d Contributes to the Development of Anaplastic Thyroid Carcinoma Targeting the Polycomb Protein EZH2

(2012) Francesco Esposito et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells

(2012) Junko Kikuchi et al.   LUNG CANCER

MicroRNA-98 and microRNA-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma

(2012) Sheng-Dong Huang et al.   Molecular Cancer

EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex

(2012) Ji Min Lee et al.   MOLECULAR CELL

Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer

(2012) Irfan A. Asangani et al.   MOLECULAR CELL

Modular regulatory principles of large non-coding RNAs

(2012) Mitchell Guttman et al.   NATURE

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

Loss of Let-7 Up-Regulates EZH2 in Prostate Cancer Consistent with the Acquisition of Cancer Stem Cell Signatures That Are Attenuated by BR-DIM

(2012) Dejuan Kong et al.   PLoS One

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

Changes in histone deacetylase (HDAC) expression patterns and activity of HDAC inhibitors in urothelial cancers

(2012) Günter Niegisch et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

(2012) Sharad K. Verma et al.   ACS Medicinal Chemistry Letters

Molecular architecture of human polycomb repressive complex 2

(2012) Claudio Ciferri et al.   eLife

Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins

(2012) Gary LeRoy et al.   GENOME BIOLOGY

Long non-coding RNAs in cancer progression

(2012) Keiko Tano et al.   Frontiers in Genetics

Carcinogenesis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2

(2011) Osamu Nakahara et al.   ANNALS OF SURGICAL ONCOLOGY

RAS oncogenic signal upregulates EZH2 in pancreatic cancer

(2011) Satoshi Fujii et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer

(2011) Qi Cao et al.   CANCER CELL

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling

(2011) Chun-Ju Chang et al.   CANCER CELL

Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting GSK-3β

(2011) Masaaki Tsukigi et al.   CANCER LETTERS

Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers

(2011) R. Kogo et al.   CANCER RESEARCH

(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells

(2011) S. R. Choudhury et al.   CARCINOGENESIS

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

Epigenetic aberrations during oncogenesis

(2011) Maria Hatziapostolou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Treatment of Muscle-invasive and Metastatic Bladder Cancer: Update of the EAU Guidelines

(2011) Arnulf Stenzl et al.   EUROPEAN UROLOGY

The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2

(2011) Fang Zheng et al.   GUT

Urinary schistosomiasis in France

(2011) Antoine Douard et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Epigenetic Regulation of Cancer-Associated Genes in Ovarian Cancer

(2011) Mi Jeong Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysine-specific Demethylase 2B (KDM2B)-let-7-Enhancer of Zester Homolog 2 (EZH2) Pathway Regulates Cell Cycle Progression and Senescence in Primary Cells

(2011) Alexandros Tzatsos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin-dependent Kinase 1 (CDK1)-mediated Phosphorylation of Enhancer of Zeste 2 (Ezh2) Regulates Its Stability

(2011) Susan C. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An outbreak of schistosomiasis in travellers returning from endemic areas: the importance of rigorous tracing in peer groups exposed to risk of infection

(2011) O. Blach et al.   JOURNAL OF PUBLIC HEALTH

MicroRNA-101 Exerts Tumor-Suppressive Functions in Non-small Cell Lung Cancer through Directly Targeting Enhancer of Zeste Homolog 2

(2011) Ji-guang Zhang et al.   Journal of Thoracic Oncology

Myc Regulates the Transcription of the PRC2 Gene To Control the Expression of Developmental Genes in Embryonic Stem Cells

(2011) F. Neri et al.   MOLECULAR AND CELLULAR BIOLOGY

Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer

(2011) Francesco Crea et al.   Molecular Cancer

The functional role of long non-coding RNA in human carcinomas

(2011) Ewan A Gibb et al.   Molecular Cancer

FGF-2 Regulates Cell Proliferation, Migration, and Angiogenesis through an NDY1/KDM2B-miR-101-EZH2 Pathway

(2011) Filippos Kottakis et al.   MOLECULAR CELL

Context-Specific Regulation of NF-κB Target Gene Expression by EZH2 in Breast Cancers

(2011) Shuet Theng Lee et al.   MOLECULAR CELL

Epigenetic regulation of microRNAs in cancer: An integrated review of literature

(2011) Tanja Kunej et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

(2011) John R Prensner et al.   NATURE BIOTECHNOLOGY

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

Determinants of Sensitivity to DZNep Induced Apoptosis in Multiple Myeloma Cells

(2011) Zhigang Xie et al.   PLoS One

Structural and Functional Differences in the Long Non-Coding RNA Hotair in Mouse and Human

(2011) Patrick Schorderet et al.   PLoS Genetics

Histone lysine methylation and demethylation pathways in cancer

(2010) Radhika A. Varier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

(2010) T. Roger et al.   BLOOD

Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo

(2010) Sha Hu et al.   CANCER BIOLOGY & THERAPY

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

(2010) Martin Sauvageau et al.   Cell Stem Cell

MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion

(2010) Hui-Ju Wang et al.   EUROPEAN JOURNAL OF CANCER

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA

(2010) S. Kaneko et al.   GENES & DEVELOPMENT

Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer

(2010) Erik D. Wiklund et al.   INTERNATIONAL JOURNAL OF CANCER

RORα Attenuates Wnt/β-Catenin Signaling by PKCα-Dependent Phosphorylation in Colon Cancer

(2010) Ji Min Lee et al.   MOLECULAR CELL

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 INK4B tumor suppressor gene

(2010) Y Kotake et al.   ONCOGENE

FGFR3, HRAS, KRAS, NRAS and PIK3CA Mutations in Bladder Cancer and Their Potential as Biomarkers for Surveillance and Therapy

(2010) Lucie C. Kompier et al.   PLoS One

Molecular Signals of Epigenetic States

(2010) Roberto Bonasio et al.   SCIENCE

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2

(2009) J. M. Friedman et al.   CANCER RESEARCH

Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells

(2009) M. Hussain et al.   CANCER RESEARCH

Spectrum of Phosphatidylinositol 3-Kinase Pathway Gene Alterations in Bladder Cancer

(2009) F. M. Platt et al.   CLINICAL CANCER RESEARCH

The Impact of Lymphadenectomy and Lymph Node Metastasis on the Outcomes of Radical Cystectomy for Bladder Cancer

(2009) Alexander Karl et al.   EUROPEAN UROLOGY

Generation of a Concise Gene Panel for Outcome Prediction in Urinary Bladder Cancer

(2009) Anirban P. Mitra et al.   JOURNAL OF CLINICAL ONCOLOGY

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Mir-214-Dependent Regulation of the Polycomb Protein Ezh2 in Skeletal Muscle and Embryonic Stem Cells

(2009) Aster H. Juan et al.   MOLECULAR CELL

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Protein methyltransferases as a target class for drug discovery

(2009) Robert A. Copeland et al.   NATURE REVIEWS DRUG DISCOVERY

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

(2009) K. S. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation patterns in lung carcinomas

(2009) Gerd P. Pfeifer et al.   SEMINARS IN CANCER BIOLOGY

Histone methyltransferases in cancer

(2009) Mareike Albert et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The present and future burden of urinary bladder cancer in the world

(2009) Martine Ploeg et al.   WORLD JOURNAL OF UROLOGY

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

(2008) S. Sander et al.   BLOOD

DNA methylomes, histone codes and miRNAs: Tying it all together

(2008) Sònia Guil et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Roles of the EZH2 histone methyltransferase in cancer epigenetics

(2008) Jeffrey A. Simon et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

(2008) Yutaka Kondo et al.   NATURE GENETICS

Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1

(2008) M E Gonzalez et al.   ONCOGENE

The Polycomb Repressive Complex 2 Is a Potential Target of SUMO Modifications

(2008) Eva Madi Riising et al.   PLoS One

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

(2008) E. N. Gal-Yam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection: Is it a cause of bladder cancer?

(2008) Hassan Abol-enein   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin

(2008) T. Nagano et al.   SCIENCE

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE

Epigenetic Marking Prepares the HumanHOXACluster for Activation During Differentiation of Pluripotent Cells

(2008) Stuart P. Atkinson et al.   STEM CELLS