Roles of Ubiquitination and SUMOylation on Prostate Cancer: Mechanisms and Clinical Implications

Ubiquitin-specific protease 7 accelerates p14ARFdegradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression

(2015) Jia-Bin Cai et al.   HEPATOLOGY

Switching and withdrawing hormonal agents for castration-resistant prostate cancer

(2015) David Lorente et al.   Nature Reviews Urology

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

(2015) Wenfu Lu et al.   Oncotarget

SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

(2015) Jiateng Zhong et al.   Oncotarget

SCFβ-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

(2015) Jia Liu et al.   Oncotarget

The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth

(2015) Yuh-Shyan Tsai et al.   Oncotarget

SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade

(2015) Rivki Cashman et al.   Oncotarget

Ubiquitination of p53 is Involved in Troglitazone Induced Apoptosis in Cervical Cancer Cells

(2014) Hui-Min Chen et al.   Asian Pacific Journal of Cancer Prevention

SUMOylation proteins in breast cancer

(2014) Alaa T. Alshareeda et al.   BREAST CANCER RESEARCH AND TREATMENT

Mouse models of prostate cancer: picking the best model for the question

(2014) Magdalena M. Grabowska et al.   CANCER AND METASTASIS REVIEWS

Regulation of Epithelial-Mesenchymal Transition through SUMOylation of Transcription Factors

(2014) M. V. Bogachek et al.   CANCER RESEARCH

NF- B Gene Signature Predicts Prostate Cancer Progression

(2014) R. Jin et al.   CANCER RESEARCH

SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway

(2014) Jianmin Gu et al.   CARDIOVASCULAR RESEARCH

Skp2: A dream target in the coming age of cancer therapy

(2014) Chia-Hsin Chan et al.   CELL CYCLE

Important Role of SUMOylation of Spliceosome Factors in Prostate Cancer Cells

(2014) Donghua Wen et al.   JOURNAL OF PROTEOME RESEARCH

FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype

(2014) David J DeGraff et al.   LABORATORY INVESTIGATION

Ubiquitination involved enzymes and cancer

(2014) Mei-juan Zhou et al.   MEDICAL ONCOLOGY

Crosstalk Between Nuclear MET and SOX9/β-Catenin Correlates with Castration-Resistant Prostate Cancer

(2014) Yingqiu Xie et al.   MOLECULAR ENDOCRINOLOGY

Nuclear Mobility and Activity of FOXA1 with Androgen Receptor Are Regulated by SUMOylation

(2014) Päivi Sutinen et al.   MOLECULAR ENDOCRINOLOGY

NFI Transcription Factors Interact with FOXA1 to Regulate Prostate-Specific Gene Expression

(2014) Magdalena M. Grabowska et al.   MOLECULAR ENDOCRINOLOGY

Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis

(2014) Yingqiu Xie et al.   Molecular Oncology

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner

(2014) Päivi Sutinen et al.   NUCLEIC ACIDS RESEARCH

The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway

(2014) Y Sun et al.   ONCOGENE

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation

(2014) M P Licciardello et al.   ONCOGENE

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth

(2014) H.-E. Hsia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

(2014) J.-P. P. Theurillat et al.   SCIENCE

SUMO-specific protease 1 modulates cadmium-augmented transcriptional activity of androgen receptor (AR) by reversing AR SUMOylation

(2014) Ruiqin Wu et al.   TOXICOLOGY LETTERS

Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program

(2014) Hong-Jian Jin et al.   Nature Communications

The Role of Ubiquitination and Sumoylation in Diabetic Nephropathy

(2014) Chenlin Gao et al.   Biomed Research International

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity

(2013) Jianfei Qi et al.   CANCER CELL

Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis

(2013) R. Li et al.   CANCER RESEARCH

RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation

(2013) James T Lee et al.   CELL RESEARCH

SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase

(2013) Murilo TD Bueno et al.   Epigenetics

Posttranslational Modification of the Androgen Receptor in Prostate Cancer

(2013) Travis Van der Steen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies

(2013) Melanie Theodore Malloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIASxα Ligase Enhances SUMO1 Modification of PTEN Protein as a SUMO E3 Ligase

(2013) Weibin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies

(2013) Lindsey N. Micel et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond

(2013) Ziyou Cui et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis

(2013) Lina Sun et al.   JNCI-Journal of the National Cancer Institute

ARF Represses Androgen Receptor Transactivation in Prostate Cancer

(2013) Wenfu Lu et al.   MOLECULAR ENDOCRINOLOGY

Mutation in E1, the Ubiquitin Activating Enzyme, Reduces Drosophila Lifespan and Results in Motor Impairment

(2013) Hsiu-Yu Liu et al.   PLoS One

Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer

(2013) Bo Li et al.   PROSTATE

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Cycles of Ubiquitination and Deubiquitination Critically Regulate Growth Factor-Mediated Activation of Akt Signaling

(2013) W.-L. Yang et al.   Science Signaling

PML, SUMOylation, and Senescence

(2013) Lisa Ivanschitz et al.   Frontiers in Oncology

Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin

(2012) Brigitte Gerard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Ubiquitin-dependent Regulation of Phospho-AKT Dynamics by the Ubiquitin E3 Ligase, NEDD4-1, in the Insulin-like Growth Factor-1 Response

(2012) Chuan-Dong Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation

(2012) Syed Feroj Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the androgen receptor by post-translational modifications

(2012) Kelly Coffey et al.   JOURNAL OF ENDOCRINOLOGY

Dynamic SUMOylation Is Linked to the Activity Cycles of Androgen Receptor in the Cell Nucleus

(2012) M. Rytinki et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer

(2012) Ioannis A. Voutsadakis   MOLECULAR BIOLOGY REPORTS

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

(2012) Bertrand Boisson et al.   NATURE IMMUNOLOGY

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SUMO-specific protease 1 promotes prostate cancer progression and metastasis

(2012) Q Wang et al.   ONCOGENE

SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2

(2012) Yongyan Wu et al.   PLoS One

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

Ubiquitination and the Ubiquitin–Proteasome System as regulators of transcription and transcription factorsin epithelial mesenchymal transition of cancer

(2012) Ioannis A. Voutsadakis   TUMOR BIOLOGY

Prognostic impact of SUMO-specific protease 1 (SENP1) in prostate cancer patients undergoing radical prostatectomy

(2012) Tao Li et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

(2012) Jian Huang et al.   Nature Communications

CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

(2012) Jae Hyang Lim et al.   Nature Communications

Regulation of FOXO protein stability via ubiquitination and proteasome degradation

(2011) Haojie Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Defective sumoylation pathway directs congenital heart disease

(2011) Jun Wang et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

U-box-type ubiquitin E4 ligase, UFD2a attenuates cisplatin mediated degradation of ΔNp63α

(2011) Aditi Chatterjee et al.   CELL CYCLE

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

(2011) Biswajyoti Sahu et al.   EMBO JOURNAL

SUMOylation and de-SUMOylation in response to DNA damage

(2011) Hong Dou et al.   FEBS LETTERS

The mouse small ubiquitin-like modifier-2 (SUMO-2) inhibits interleukin-12 (IL-12) production in mature dendritic cells by blocking the translocation of the p65 subunit of NFκB into the nucleus

(2011) Eun Mi Kim et al.   MOLECULAR IMMUNOLOGY

Expression of Arf Tumor Suppressor in Spermatogonia Facilitates Meiotic Progression in Male Germ Cells

(2011) Michelle L. Churchman et al.   PLoS Genetics

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

(2010) G. W. Xu et al.   BLOOD

Regulation of Akt signaling activation by ubiquitination

(2010) Wei-Lei Yang et al.   CELL CYCLE

Molecular Pathways in the Progression of Hormone-Independent and Metastatic Prostate Cancer

(2010) B. Wegiel et al.   CURRENT CANCER DRUG TARGETS

Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues

(2010) Stergios J. Moschos et al.   HUMAN PATHOLOGY

SENP1 Induces Prostatic Intraepithelial Neoplasia through Multiple Mechanisms

(2010) Tasneem Bawa-Khalfe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

(2010) Delin Chen et al.   NATURE

Post-translational modification by SUMO

(2010) Zara Hannoun et al.   TOXICOLOGY

Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6-Induced Ubiquitination

(2009) Kexin Xu et al.   CANCER CELL

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

(2009) Isao Fukuda et al.   CHEMISTRY & BIOLOGY

Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner

(2009) S Zhu et al.   ONCOGENE

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Differential p53-Independent Outcomes of p19Arf Loss in Oncogenesis

(2009) Z. Chen et al.   Science Signaling

Sumoylation and human disease pathogenesis

(2009) Kevin D. Sarge et al.   TRENDS IN BIOCHEMICAL SCIENCES

PTEN regulation by Akt–EGR1–ARF–PTEN axis

(2008) Jianxiu Yu et al.   EMBO JOURNAL

Histone Deacetylase 7 Promotes PML Sumoylation and Is Essential for PML Nuclear Body Formation

(2008) C. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

SUMO-Specific Protease 1 (SENP1) Reverses the Hormone-Augmented SUMOylation of Androgen Receptor and Modulates Gene Responses in Prostate Cancer Cells

(2008) Sanna Kaikkonen et al.   MOLECULAR ENDOCRINOLOGY

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

(2008) Hongwu Zheng et al.   NATURE