Article
Biotechnology & Applied Microbiology
Bingren Tian, Dan Xu, Wanrong Li, Jie Wang, Jianhua Cheng, Yumei Liu
Summary: This study aimed to investigate the regulatory and shaping effects of HBA/HP-beta-CD on the proteome of L. monocytogenes. The results showed that HBA/HP-beta-CD exhibited significant antibacterial activity against L. monocytogenes, and the changes in the proteome were mainly associated with carbohydrate metabolism, protein synthesis, cell wall composition, and cell division.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Immunology
Tom Houben, Tulasi Yadati, Robbin de Kruijf, Marion J. J. Gijbels, Joost J. F. P. Luiken, Marc van Zandvoort, Dimitris Kapsokalyvas, Dieter Luetjohann, Marit Westerterp, Jogchum Plat, David Leake, Ronit Shiri-Sverdlov
Summary: 2-hydroxypropyl-beta-cyclodextrin is considered a novel pharmacological compound with the potential to decrease cellular cholesterol levels, but recent studies have shown that its use may lead to inflammatory responses, which are dependent on exposure time.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Kelvin C. M. Lee, Jochen Guck, Keisuke Goda, Kevin K. Tsia
Summary: The biophysical properties of cells provide crucial information about their identities, homeostatic state, and disease pathogenesis, which can now be accessed through advances in biophysical cytometry. To fully unleash the potential of biophysical cytometry, further research and standardization are needed in exploring cellular biophysical content and protocols. Overcoming these barriers will not only lead to a better mechanistic understanding of biological systems, but also help identify new cost-effective disease biomarkers.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
Anna Ryschich, Yan Dong, Michael Schaefer, Eduard Ryschich, Svetlana Karakhanova
Summary: This study developed and characterized a novel antibody clone, DWH24, which can visualize and quantify dead cells. Unlike conventional markers, DWH24 binding is independent of calcium and protein, making it a versatile tool for cell death analysis.
METHODS AND APPLICATIONS IN FLUORESCENCE
(2023)
Article
Pharmacology & Pharmacy
Hamid Saeed Shah, Sumera Zaib, Imtiaz Khan, Mahmoud A. Sliem, Osama Alharbi, Mohammed Al-Ghorbani, Zobia Jawad, Kiran Shahzadi, Sajjad Awan
Summary: This study demonstrates the potential therapeutic effects of beta-cyclodextrin based nanosponges for the treatment of breast cancer. These nanosponges show high cytotoxicity and induce DNA damage, leading to a reduction in tumor weight and increased survival rates.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Elsi Haddad, Marielle Pages, Frederic Violleau, Olivier Marsan, Marie-Helene Manero, Romain Richard, Jean-Philippe Torre
Summary: Ozonized (2-Hydroxypropyl)-beta-cyclodextrins were synthesized and characterized, and their oxidizing power was studied. The stability of their oxidative properties over time was evaluated, and their antimicrobial efficiency against Escherichia coli and Streptococcus uberis was confirmed.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Mechanical
Sebastian Sachs, Manuel Ratz, Patrick Maeder, Jorg Koenig, Christian Cierpka
Summary: The astigmatism particle tracking velocimetry is extended by a deterministic algorithm and a deep neural network (DNN) to include size classification of particles of multimodal size distribution. By extracting particle images from the experimentally acquired images and placing them on a synthetic background, semi-synthetic images with consistent ground truth are generated. The present contribution paves the way for quantitative evaluation of microfluidic separation and mixing processes.
EXPERIMENTS IN FLUIDS
(2023)
Article
Polymer Science
Nutsarun Wangsawangrung, Chasuda Choipang, Sonthaya Chaiarwut, Pongpol Ekabutr, Orawan Suwantong, Piyachat Chuysinuan, Supanna Techasakul, Pitt Supaphol
Summary: This study developed a polyvinyl alcohol hydrogel loaded with quercetin/cyclodextrin inclusion complex, which demonstrated enhanced stability and solubility. The hydrogel showed biocompatibility with cells and exhibited higher antioxidant activity compared to free quercetin. It can be considered as a delivery system for wound-healing applications.
Article
Chemistry, Physical
Marian Novac, Adina Magdalena Musuc, Emma Adriana Ozon, Iulian Sarbu, Mirela Adriana Mitu, Adriana Rusu, Simona Petrescu, Irina Atkinson, Daniela Gheorghe, Dumitru Lupuliasa
Summary: The study focused on the development of new orally dispersible tablets containing amlodipine inclusion complexes in cyclodextrins to improve drug solubility. Solid inclusion complexes were obtained through different methods, with lyophilization proving to be the most effective. Formulations based on silicified microcrystalline cellulose showed good flowability and compressibility, making them ideal for manufacturing orally dispersible tablets.
Article
Food Science & Technology
Niloufar Sharif, Mohammad-Taghi Golmakani, Mohammad Mahdi Hajjari, Elham Aghaee, Jahan Bakhsh Ghasemi
Summary: The electrospinning process was used to fabricate hydroxypropyl-beta-cyclodextrin fibers mat incorporating cuminaldehyde, with the inclusion complex formation between the two components confirmed by computational molecular docking. Various analytical techniques were employed to confirm the suitability and stability of the fibers, showing promising antibacterial activity against Escherichia coli and Staphylococcus aureus.
FOOD PACKAGING AND SHELF LIFE
(2021)
Article
Biochemistry & Molecular Biology
Vasiliki Palli, Georgios Leonis, Nikoletta Zoupanou, Nikitas Georgiou, Maria Chountoulesi, Nikolaos Naziris, Demeter Tzeli, Costas Demetzos, Georgia Valsami, Konstantinos D. Marousis, Georgios A. Spyroulias, Thomas Mavromoustakos
Summary: In this study, the molecular interactions between losartan potassium salt and 2-hydroxypropyl-beta-cyclodextrin were investigated using experimental methods including Differential Scanning Calorimetry, Nuclear Magnetic Resonance, and Molecular Dynamics. The results demonstrated the complexation of losartan potassium salt with 2-hydroxypropyl-beta-cyclodextrin, suggesting the potential for further biological experiments.
Article
Engineering, Chemical
Nan Li, Zhi Wang, Jixiao Wang
Summary: Carbonic anhydrase (CA)-inspired membranes were developed by incorporating hydroxypropyl-beta-cyclodextrins (H beta-CDs) into polyamide networks. The hydrophobic inner cavities of H beta-CDs mimic the hydrophobic pockets of CA enzymes. The introduction of H beta-CDs enhances the transport of CO2 molecules and polar components, making these membranes suitable for CO2 separation.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Anna Stasilowicz, Natalia Rosiak, Ewa Tykarska, Maciej Kozak, Jacek Jenczyk, Piotr Szulc, Joanna Kobus-Cisowska, Kornelia Lewandowska, Anita Plazinska, Wojciech Plazinski, Judyta Cielecka-Piontek
Summary: Research shows that combining piperine with HP-β-CD significantly increases its bioavailability, permeability, and maintains its biological activity, including antioxidant potential and enzyme inhibition beneficial for inflammation and neurodegenerative changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Emma Adriana Ozon, Marian Novac, Daniela Gheorghe, Adina Magdalena Musuc, Mirela Adriana Mitu, Iulian Sarbu, Valentina Anuta, Adriana Rusu, Simona Petrescu, Irina Atkinson, Dumitru Lupuliasa
Summary: The novelty of this study lies in the development of new orodispersible tablets containing nifedipine as the active ingredient. The study successfully prepared inclusion complexes of nifedipine with two derivatives of beta-cyclodextrin and analyzed their physicochemical properties. Orodispersible tablets containing the inclusion complexes were also successfully manufactured.
Article
Neurosciences
Danielle A. Becktel, Jacob C. Zbesko, Jennifer B. Frye, Amanda G. Chung, Megan Hayes, Kylie Calderon, Jeffrey W. Grover, Anna Li, Frankie G. Garcia, Marco A. Tavera-Garcia, Rick G. Schnellmann, Hsin-Jung Joyce Wu, Thuy-Vi V. Nguyen, Kristian P. Doyle
Summary: This study suggests that systemic treatment with HP beta CD after stroke can attenuate chronic inflammation, prevent neurodegeneration, and improve cognitive function.
JOURNAL OF NEUROSCIENCE
(2022)