A Review of the Pathophysiology and Potential Biomarkers for Peripheral Artery Disease

The relevance of epigenetics to occlusive cerebral and peripheral arterial disease

(2015) Smriti Murali Krishna et al.   CLINICAL SCIENCE

Abnormal myofiber morphology and limb dysfunction in claudication

(2015) Panagiotis Koutakis et al.   JOURNAL OF SURGICAL RESEARCH

Gender and racial differences in endothelial oxidative stress and inflammation in patients with symptomatic peripheral artery disease

(2015) Andrew W. Gardner et al.   JOURNAL OF VASCULAR SURGERY

Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease

(2015) Shaundeep Sen et al.   CLINICAL SCIENCE

Comparative effectiveness of endovascular and surgical revascularization for patients with peripheral artery disease and critical limb ischemia

(2014) W. Schuyler Jones et al.   AMERICAN HEART JOURNAL

Effects of Native and Myeloperoxidase-Modified Apolipoprotein A-I on Reverse Cholesterol Transport and Atherosclerosis in Mice

(2014) Bernd Hewing et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comparison of the Serum Lipidome in Patients With Abdominal Aortic Aneurysm and Peripheral Artery Disease

(2014) J. V. Moxon et al.   Circulation-Cardiovascular Genetics

Residual thrombin generation potential is inversely linked to the occurrence of atherothrombotic events in patients with peripheral arterial disease

(2014) Thomas Gremmel et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Gene therapy for peripheral arterial disease

(2014) Munehisa Shimamura et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity

(2014) V. W. M. Virginio et al.   FREE RADICAL RESEARCH

Thrombosis formation on atherosclerotic lesions and plaque rupture

(2014) L. Badimon et al.   JOURNAL OF INTERNAL MEDICINE

Levels and values of lipoprotein-associated phospholipase A2, galectin-3, RhoA/ROCK, and endothelial progenitor cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and clopidogrel combination therapy

(2014) Jiunn-Jye Sheu et al.   Journal of Translational Medicine

C-reactive protein and brain natriuretic peptide as predictors of adverse events after lower extremity endovascular revascularization

(2014) Patrick A. Stone et al.   JOURNAL OF VASCULAR SURGERY

Walking disability in patients with peripheral artery disease is associated with arterial endothelial function

(2014) S. Marlene Grenon et al.   JOURNAL OF VASCULAR SURGERY

An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease

(2014) Ryosuke Kikuchi et al.   NATURE MEDICINE

Peripheral artery disease is a coronary heart disease risk equivalent among both men and women: results from a nationwide study

(2014) Sumeet Subherwal et al.   European Journal of Preventive Cardiology

Galectin‐3, a Biomarker Linking Oxidative Stress and Inflammation With the Clinical Outcomes of Patients With Atherothrombosis

(2014) Julio Madrigal‐Matute et al.   Journal of the American Heart Association

Association of Lower Extremity Performance With Cardiovascular and All‐Cause Mortality in Patients With Peripheral Artery Disease: A Systematic Review and Meta‐Analysis

(2014) Dylan R. Morris et al.   Journal of the American Heart Association

Impaired Vascular Endothelial Growth Factor A and Inflammation in Patients With Peripheral Artery Disease

(2013) Andrew W. Gardner et al.   ANGIOLOGY

C-Reactive Protein, Fatal and Nonfatal Coronary Artery Disease, Stroke, and Peripheral Artery Disease in the Prospective EPIC-Norfolk Cohort Study

(2013) Diederik F. van Wijk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Elevated Rho-Kinase Activity as a Marker Indicating Atherosclerosis and Inflammation Burden in Polyvascular Disease Patients With Concomitant Coronary and Peripheral Arterial Disease

(2013) Ming Dong et al.   CLINICAL CARDIOLOGY

Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success

(2013) G. Dragneva et al.   Disease Models & Mechanisms

Nitric oxide and reactive oxygen species in limb vascular function: what is the effect of physical activity?

(2013) L. Gliemann et al.   FREE RADICAL RESEARCH

Oxidation-Specific Biomarkers and Risk of Peripheral Artery Disease

(2013) Monica L. Bertoia et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease

(2013) Dustin J Weiss et al.   Journal of Translational Medicine

Living in a medically underserved county is an independent risk factor for major limb amputation

(2013) Katharine L. McGinigle et al.   JOURNAL OF VASCULAR SURGERY

Presentation, treatment, and outcome differences between men and women undergoing revascularization or amputation for lower extremity peripheral arterial disease

(2013) Ruby C. Lo et al.   JOURNAL OF VASCULAR SURGERY

Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis

(2013) F Gerald R Fowkes et al.   LANCET

Barriers to screening and diagnosis of peripheral artery disease by general practitioners

(2013) Kate Jamilla Haigh et al.   VASCULAR MEDICINE

Correlation between plasma lipoprotein-associated phospholipase A2 and peripheral arterial disease

(2013) SHUAI-BING LI et al.   Experimental and Therapeutic Medicine

YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes

(2012) Klaudija Batinic et al.   ATHEROSCLEROSIS

Patients with unrecognized peripheral arterial disease (PAD) assessed by ankle-brachial index (ABI) present a defined profile of proinflammatory markers compared to healthy subjects

(2012) Salvatore Santo Signorelli et al.   CYTOKINE

NOX2 up-regulation is associated with artery dysfunction in patients with peripheral artery disease

(2012) Lorenzo Loffredo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

An integrated biochemical prediction model of all-cause mortality in patients undergoing lower extremity bypass surgery for advanced peripheral artery disease

(2012) Christopher D. Owens et al.   JOURNAL OF VASCULAR SURGERY

Cellular Therapy With Ixmyelocel-T to Treat Critical Limb Ischemia: The Randomized, Double-blind, Placebo-controlled RESTORE-CLI Trial

(2012) Richard J Powell et al.   MOLECULAR THERAPY

Higher serum levels of soluble intracellular cell adhesion molecule-1 and soluble vascular cell adhesion molecule predict peripheral artery disease in haemodialysis patients

(2012) CHI-HUNG CHENG et al.   NEPHROLOGY

Effects of a Novel Pharmacologic Inhibitor of Myeloperoxidase in a Mouse Atherosclerosis Model

(2012) Cuiqing Liu et al.   PLoS One

A validated biomarker panel to identify peripheral artery disease

(2012) William R Hiatt et al.   VASCULAR MEDICINE

Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training

(2012) W Schuyler Jones et al.   VASCULAR MEDICINE

Peripheral artery disease, biomarkers, and darapladib

(2011) Jeffrey S. Berger et al.   AMERICAN HEART JOURNAL

Serum N-Terminal Pro-B-Type Natriuretic Peptide Levels Are Associated With Functional Capacity in Patients With Peripheral Arterial Disease

(2011) Jin Fan et al.   ANGIOLOGY

Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease

(2011) Anna Rull et al.   ATHEROSCLEROSIS

To screen or not to screen for peripheral arterial disease in subjects aged 80 and over in primary health care: a cross-sectional analysis from the BELFRAIL study

(2011) Stein Bergiers et al.   BMC Family Practice

High-Molecular-Weight and Total Adiponectin Levels and Incident Symptomatic Peripheral Artery Disease in Women

(2011) Deborah Y. Ho et al.   CIRCULATION

Emerging Biomarkers in Heart Failure

(2011) R. R. J. van Kimmenade et al.   CLINICAL CHEMISTRY

Plasma myeloperoxidase level and peripheral arterial disease

(2011) Helmuth Haslacher et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Safety of a non-viral plasmid-encoding dual isoforms of hepatocyte growth factor in critical limb ischemia patients: a phase I study

(2011) T D Henry et al.   GENE THERAPY

Local control of skeletal muscle blood flow during exercise: influence of available oxygen

(2011) Darren P. Casey et al.   JOURNAL OF APPLIED PHYSIOLOGY

Number of Endothelial Progenitor Cells in Peripheral Artery Disease as a Marker of Severity and Association with Pentraxin-3, Malondialdehyde-Modified Low-Density Lipoprotein and Membrane Type-1 Matrix Metalloproteinase

(2011) Tetsuji Morishita et al.   Journal of Atherosclerosis and Thrombosis

N-acetylcysteine attenuates leukocytic inflammation and microvascular perfusion failure in critically ischemic random pattern flaps

(2011) A.C. Bächle et al.   MICROVASCULAR RESEARCH

Thrombin and vascular inflammation

(2011) Milan Popović et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Peripheral artery disease. Part 1: clinical evaluation and noninvasive diagnosis

(2011) Joe F. Lau et al.   Nature Reviews Cardiology

Arterial thrombus formation in cardiovascular disease

(2011) Giuseppe Lippi et al.   Nature Reviews Cardiology

β2-microglobulin, a novel biomarker of peripheral arterial disease, independently predicts aortic stiffness in these patients

(2011) Jaak Kals et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Effect of Homocysteine-Lowering B Vitamin Treatment on Angiographic Progression of Coronary Artery Disease: A Western Norway B Vitamin Intervention Trial (WENBIT) Substudy

(2010) Kjetil H. Løland et al.   AMERICAN JOURNAL OF CARDIOLOGY

Safety and Efficacy of Therapeutic Angiogenesis as a Novel Treatment in Patients with Critical Limb Ischemia

(2010) R. Lara-Hernandez et al.   ANNALS OF VASCULAR SURGERY

Peripheral Artery Disease Is Associated With a High CD163/TWEAK Plasma Ratio

(2010) Juan A. Moreno et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombospondin-1 Is a Plasmatic Marker of Peripheral Arterial Disease That Modulates Endothelial Progenitor Cell Angiogenic Properties

(2010) David M. Smadja et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased Serum N-Terminal Pro–B-Type Natriuretic Peptide Levels in Patients With Medial Arterial Calcification and Poorly Compressible Leg Arteries

(2010) Hayan Jouni et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an Ambulatory Elderly Population

(2010) Rosa Maria Guéant-Rodriguez et al.   ATHEROSCLEROSIS

Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease

(2010) Takuro Shinsato et al.   Journal of Cardiology

Prognostic values of C-reactive protein levels on clinical outcome after endovascular therapy in hemodialysis patients with peripheral artery disease

(2010) Hideki Ishii et al.   JOURNAL OF VASCULAR SURGERY

Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous vein

(2010) Christopher D. Owens et al.   JOURNAL OF VASCULAR SURGERY

Treatment of peripheral arterial disease using stem and progenitor cell therapy

(2010) Holger Lawall et al.   JOURNAL OF VASCULAR SURGERY

Stem cell and progenitor cell therapy in peripheral artery disease

(2010) Peter Bramlage et al.   THROMBOSIS AND HAEMOSTASIS

Matrix Metalloproteinase-9 Is Essential for Ischemia-Induced Neovascularization by Modulating Bone Marrow–Derived Endothelial Progenitor Cells

(2009) Po-Hsun Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autologous stem cell therapy for peripheral arterial disease

(2009) Gian Paolo Fadini et al.   ATHEROSCLEROSIS

Human Studies of Angiogenic Gene Therapy

(2009) Rajesh Gupta et al.   CIRCULATION RESEARCH

VEGF: A Surrogate Marker for Peripheral Vascular Disease

(2009) A. Stehr et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Meta-analysis of randomized, controlled clinical trials in angiogenesis: gene and cell therapy in peripheral arterial disease

(2009) Joaquin De Haro et al.   HEART AND VESSELS

Matrix metalloproteinases and peripheral arterial disease

(2009) Chiara Busti et al.   Internal and Emergency Medicine

The Role of Biomarkers and Genetics in Peripheral Arterial Disease

(2009) Mary M. McDermott et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Critical limb ischemia

(2009) Vinit N. Varu et al.   JOURNAL OF VASCULAR SURGERY

Nitric oxide: link between endothelial dysfunction and inflammation in patients with peripheral arterial disease of the lower limbs☆

(2009) Joaquin de Haro Miralles et al.   Interactive Cardiovascular and Thoracic Surgery

Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia

(2008) Satoaki Matoba et al.   AMERICAN HEART JOURNAL

Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study

(2008) Joanne M. Murabito et al.   ATHEROSCLEROSIS

Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation

(2008) Shihuan Kuang et al.   Cell Stem Cell

Vascular Calcification

(2008) Linda L. Demer et al.   CIRCULATION

The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-γ2 gene is associated with plasma levels of soluble RAGE (Receptor for Advanced Glycation Endproducts) and the presence of peripheral arterial disease

(2008) Mariella Catalano et al.   CLINICAL BIOCHEMISTRY

Amino-Terminal Pro-B-Type Natriuretic Peptide as Predictor of Mortality in Patients with Symptomatic Peripheral Arterial Disease: 5-Year Follow-Up Data from the Linz Peripheral Arterial Disease Study

(2008) T. Mueller et al.   CLINICAL CHEMISTRY

Endothelial Progenitor Cells in Patients with Severe Peripheral Arterial Disease

(2008) Pietro Delva et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

Emerging hurdles in stem cell therapy for peripheral vascular disease

(2008) Xabier L. Aranguren et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Plasma Levels of Soluble Tie2 and Vascular Endothelial Growth Factor Distinguish Critical Limb Ischemia From Intermittent Claudication in Patients With Peripheral Arterial Disease

(2008) Clarence M. Findley et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Circulating Blood Markers and Functional Impairment in Peripheral Arterial Disease

(2008) Mary M. McDermott et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Inflammation and oxidative stress are associated differently with endothelial function and arterial stiffness in healthy subjects and in patients with atherosclerosis

(2008) Jaak Kals et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Basic Science Review: The Myopathy of Peripheral Arterial Occlusive Disease: Part 2. Oxidative Stress, Neuropathy, and Shift in Muscle Fiber Type

(2008) Iraklis I. Pipinos et al.   Vascular and Endovascular Surgery

The Myopathy of Peripheral Arterial Occlusive Disease: Part 1. Functional and Histomorphological Changes and Evidence for Mitochondrial Dysfunction

(2008) Iraklis I. Pipinos et al.   Vascular and Endovascular Surgery

A biomarker panel for peripheral arterial disease

(2008) Eric T Fung et al.   VASCULAR MEDICINE

National health care costs of peripheral arterial disease in the Medicare population

(2008) Alan T Hirsch et al.   VASCULAR MEDICINE

Impact of gradual blood flow increase on ischaemia–reperfusion injury in the rat cremaster microcirculation model

(2007) Selahattin Ozmen et al.   Journal of Plastic Reconstructive and Aesthetic Surgery