Review
Endocrinology & Metabolism
Rui Ding, Shicong Zhu, Xiaoyan Zhao, Rensong Yue
Summary: This meta-analysis evaluated the relationship between circulating levels of VEGFs and diabetic peripheral neuropathy (DPN). The results showed that VEGF levels were significantly increased in DPN patients compared to diabetic patients without DPN and healthy individuals. However, there was no evidence to support the correlation between VEGF levels and the risk of DPN.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Haoting Zhan, Haolong Li, Chenxi Liu, Linlin Cheng, Songxin Yan, Yongzhe Li
Summary: Circulating VEGF levels are associated with autoimmune diseases and may predict disease manifestations and activity in patients, indicating potential therapeutic implications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xin Guo, Junchao Liu, Rong Zhang, Yi Jin, Xin Wang, Bo Li, Zhiyou Peng, Xing Zhang, Jiefeng Shen, Xinwu Lu, Xiaobing Liu, Guang Liu
Summary: In this study, glutaraldehyde-crosslinked polyethyleneimine (GAPEI) nanoparticles were developed as an efficient gene carrier for peripheral arterial diseases (PAD) therapy. The results showed that GAPEI exhibited higher transfection efficiency and lower cytotoxicity compared to the commercial carrier PEI25kDa. GAPEI-PTGIS nanoparticles effectively promoted the secretion of prostacyclin (PGI2), enhanced cell migration and tube formation ability, potentially through VEGF, TGF-beta 1, and FGF2 pathways.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Review
Medicine, General & Internal
Tingwei Ding, Lei Sheng, Haiyu Zhu, Hongyi Guan, Ying Wang, Haoze Guo, Yunpeng Bi, Bailin Song
Summary: This study conducted a meta-analysis on the clinical efficacy and safety of external treatment of traditional Chinese medicine (TCM) for diabetic peripheral vascular diseases. The results showed that TCM external treatment can improve vascular diameter, blood flow, and diabetes-related symptoms. This provides new methods for the clinical treatment of diabetic peripheral vascular disease.
Review
Obstetrics & Gynecology
E. G. Mulder, S. de Haas, Z. Mohseni, N. Schartmann, F. Abo Hasson, F. Alsadah, S. M. J. van Kuijk, J. van Drongelen, M. E. A. Spaanderman, C. Ghossein-Doha
Summary: During normotensive pregnancy, cardiac output gradually increases to its peak in early third trimester, while vascular resistance decreases until early third trimester before slightly increasing at term. In hypertensive pregnancies, initial increase in cardiac output is higher and vascular resistance remains stable throughout gestation compared to reference values. Monitoring haemodynamic changes in pregnancy can help identify women at risk for hypertensive complications.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Janina Krug, Magdalena L. Bochenek, Rajinikanth Gogiraju, Dagmar Laubert-Reh, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild, Christine Espinola-Klein, Katrin Schaefer
Summary: This study found that circulating sEPCR levels may serve as biomarkers of endothelial dysfunction, including angiogenesis, in individuals older than 35 years, and progressive loss of endothelial protein C receptors might be involved in the development and progression of PAD.
Review
Surgery
Max M. Lokhorst, Folkert Jolink, Sophie E. R. Horbach, Phyllis I. Spuls, Chantal M. A. M. van der Horst
Summary: Surgical treatment of vascular malformations appears to be effective and safe in many cases. However, it seems that surgery is performed predominantly in small lesions, and subtotal resection has a higher risk of recurrence than total resection.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Medicine, General & Internal
Florian Simon, Mansur Duran, Waseem Garabet, Hubert Schelzig, Michael Jacobs, Alexander Gombert
Summary: A decade ago, gene therapy was seen as a potential treatment for chronic limb-threatening ischemia, but its safety and clinical feasibility are still in question. Gene therapy can be achieved through transduction and transfection methods, but there are risks involved, such as increased neo-vascularization in undesired tissue, malignant transformation and inflammation, and arterial thrombosis. Clinical trials of gene therapy in vascular occlusive disease have shown mixed results, leaving the role of gene therapy unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Physiology
Faith K. Pizzey, Emily C. Smith, Stefanie L. Ruediger, Shelley E. Keating, Christopher D. Askew, Jeff S. Coombes, Tom G. Bailey
Summary: The review systematically analyzed current evidence on the effects of heat therapy on blood pressure and vascular function.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Clinical Neurology
James C. Mamaril-Davis, Adrian W. Gelb, Paul S. Larson
Summary: A systematic review and meta-analysis found that patients in the sham surgery control group of clinical trials for Parkinson's disease have a low risk of procedure-related adverse events and fewer complications compared to patients in the experimental groups.
MOVEMENT DISORDERS
(2023)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Dermatology
Tai-Li Chen, Ling-Ling Lee, Huei-Kai Huang, Jen-Hung Wang, Li-Yu Chen, Hou-Ren Tsai, Ching-Hui Loh, Ching-Chi Chi
Summary: This systematic review and meta-analysis revealed an increased risk of incident VTE and PVD among patients with psoriatic disease. Typical presentations of VTE or PVD should not be overlooked in patients with psoriasis. Risk factors such as obesity, physical inactivity, smoking, and varicose veins should be identified and treated in patients with psoriasis, and caution should be exercised in prescribing hormone-related therapies.
Article
Engineering, Biomedical
Shuaishuai Bian, Xiuli Zheng, Weimin Liu, Zekun Gao, Yingpeng Wan, Jihao Li, Haohui Ren, Wenjun Zhang, Chun-Sing Lee, Pengfei Wang
Summary: This study developed a pH-responsive nanoplatform for real-time monitoring of tumor vascular disruption, long-term tracking of tumor progression, and combined anti-vascular/photothermal therapy.
Review
Cardiac & Cardiovascular Systems
Madhu V. Singh, Ayotunde O. Dokun
Summary: Peripheral artery disease (PAD), caused by occlusion of peripheral arteries in the lower extremities, is a major cardiovascular disease worldwide. The coexistence of PAD and diabetes increases the risk of critical limb threatening ischemia (CLTI) with poor prognosis and high mortality. The molecular mechanism of how diabetes worsens PAD is not yet fully understood, and effective therapeutic interventions are still lacking. This review highlights the importance of understanding the molecular components that can be targeted for therapeutic purposes in PAD and diabetes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Silvia Bleda, Joaquin De Haro, Francisco Acin
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Letter
Cardiac & Cardiovascular Systems
Silvia Bleda, Joaquin de Haro, Francisco Acin
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Surgery
A. R. Naylor, J. B. Ricco, G. J. de Borst, S. Debus, J. de Haro, A. Halliday, G. Hamilton, J. Kakisis, S. Kakkos, S. Lepidi, H. S. Markus, D. J. McCabe, J. Roy, H. Sillesen, J. C. van den Berg, F. Vermassen, P. Kolh, N. Chakfe, R. J. Hinchliffe, I. Koncar, J. S. Lindholt, M. Vega de Ceniga, F. Verzini, J. Archie, S. Bellmunt, A. Chaudhuri, M. Koelemay, A. K. Lindahl, F. Padberg, M. Venermo
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2018)
Letter
Cardiac & Cardiovascular Systems
Silvia Bleda, Joaquin de Haro
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Pharmacology & Pharmacy
Joaquin de Haro, Javier Rodriguez-Padilla, Silvia Bleda, Cristina Canibano, Ignacio Michel, Francisco Acin
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2018)
Article
Cardiac & Cardiovascular Systems
Joaquin De Haro, Silvia Bleda, Carmen Gonzalez-Hidalgo, Ignacio Michel, Francisco Acin
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2019)
Letter
Cardiac & Cardiovascular Systems
Silvia Bleda, Joaquin De Haro
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Surgery
Joaquin De Haro, Silvia Bleda, Ilsem Veronica Laime, Blanca Carballido, Jhenifer Uyaguari, Francisco Acin
ANNALS OF VASCULAR SURGERY
(2019)
Letter
Surgery
Andres Reyes Valdivia, Enrique San Norberto, Rosa Moreno, Luis Miguel Salmeron Febres, Manuel Miralles, Isaac Martinez Lopez, Amer Zanabili, Jose Antonio Gonzalez Fajardo
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
E. M. San Norberto, J. De Haro, R. Pena, L. Riera, D. Fernandez-Caballero, A. Sesma, P. Rodriguez-Cabeza, M. Ballesteros, E. Gomez-Jabalera, G. T. Taneva, C. Aparicio, N. Moradillo, I Soguero, A. M. Badrenas, R. Lara, A. Torres, V. A. Sala, C. Vaquero
Summary: Vascular procedures in patients with COVID-19 infection during the 2020 pandemic showed a poor 30-day survival rate, with factors such as age, preoperative indicators, and postoperative complications identified as main predictors of mortality.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Peripheral Vascular Disease
Julio Gonzalez-Hernandez, Cesar Varela, Ignacio Michel, Ilsem Laime, Jhenifer Uyaguari, Jose R. March
Summary: The study found that high preoperative NLR values are associated with severe and deep infected ulcers, predicting primary patency loss, higher major adverse limb events, and worse amputation-free survival rates on long-term follow-up after infrainguinal surgical revascularization.
INTERNATIONAL ANGIOLOGY
(2021)
Article
Peripheral Vascular Disease
Silvia Bleda, Joaquin de Haro, Isabel Sanchez, Ilsem Laime, Francisco Acin
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2020)
Article
Cardiac & Cardiovascular Systems
Carmen Gonzalez-Hidalgo, Joaquin De Haro, Silvia Bleda, Cristina Canibano, Ignacio Michel, Francisco Acin
THERAPEUTIC ADVANCES IN CARDIOVASCULAR DISEASE
(2018)
Article
Cardiac & Cardiovascular Systems
Joaquin De Haro, Ignacio Michel, Silvia Bleda, Cristina Canibano, Francisco Acin
AMERICAN JOURNAL OF CARDIOLOGY
(2017)
Letter
Peripheral Vascular Disease
Enrique M. San Norberto, Joaquin de Haro