Thrombin and vascular inflammation

Mature Dendritic Cells Express Functional Thrombin Receptors Triggering Chemotaxis and CCL18/Pulmonary and Activation-Regulated Chemokine Induction

(2014) X. Li et al.   JOURNAL OF IMMUNOLOGY

Insulin, Thrombin, ERK1/2 Kinase and Vascular Smooth Muscle Cells Proliferation

(2011) Esma R. Isenovic et al.   CURRENT PHARMACEUTICAL DESIGN

Relation of Platelet Count to Bleeding and Vascular Complications in Patients Undergoing Coronary Angiography

(2010) Param Vidwan et al.   AMERICAN JOURNAL OF CARDIOLOGY

Involvement of ERK1/2 Kinase in Insulin-and Thrombin-Stimulated Vascular Smooth Muscle Cell Proliferation

(2010) Esma R. Isenović et al.   ANGIOLOGY

Activation of Protease-Activated Receptors 3 and 4 Accelerates Tissue Factor–Induced Thrombin Generation on the Surface of Vascular Smooth Muscle Cells

(2010) Param Vidwan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Functionally Active P2Y12 ADP Receptors by Thrombin in Human Smooth Muscle Cells and the Presence of P2Y12 in Carotid Artery Lesions

(2010) Bernhard H. Rauch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High Glucose Enhances Thrombin Responses via Protease-Activated Receptor-4 in Human Vascular Smooth Muscle Cells

(2010) Seema Dangwal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombin promotes proinflammatory phenotype in human vascular smooth muscle cell

(2010) Sung-Woon Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation

(2010) Chin-Chung Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Thrombin induces platelet activation in the absence of functional protease activated receptors 1 and 4 and glycoprotein Ib-IX-V

(2010) Paolo Lova et al.   CELLULAR SIGNALLING

NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis

(2010) Aleksandr E. Vendrov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma Kallikrein Promotes Epidermal Growth Factor Receptor Transactivation and Signaling in Vascular Smooth Muscle through Direct Activation of Protease-activated Receptors

(2010) Rany T. Abdallah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism of Melanoma-Associated Thrombin Activity and von Willebrand Factor Release from Endothelial Cells

(2010) Nina Kerk et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Signaling by members of the TGF-β family in vascular morphogenesis and disease

(2010) Evangelia Pardali et al.   TRENDS IN CELL BIOLOGY

Impaired Fibrinolysis in the Antiphospholipid Syndrome

(2010) Katie A. Krone et al.   Current Rheumatology Reports

Protease-activated receptors in cardiovascular health and diseases

(2009) Rahman Shah   AMERICAN HEART JOURNAL

Thrombin Induces EGF Receptor Expression and Cell Proliferation via a PKC(δ)/c-Src-Dependent Pathway in Vascular Smooth Muscle Cells

(2009) Hsi-Lung Hsieh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombin regulates matrix metalloproteinase-9 expression in human monocytes

(2009) Chi-Jen Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT

(2009) A. C. Rosenkranz et al.   CARDIOVASCULAR RESEARCH

Thrombin Stimulates Smooth Muscle Cell Differentiation From Peripheral Blood Mononuclear Cells via Protease-Activated Receptor-1, RhoA, and Myocardin

(2009) Kenneth Martin et al.   CIRCULATION RESEARCH

B-Type Natriuretic Peptide: Endogenous Regulator of Myocardial Structure, Biomarker and Therapeutic Target

(2009) Rebecca Ritchie et al.   CURRENT MOLECULAR MEDICINE

Platelet functions beyond hemostasis

(2009) S. S. SMYTH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

Platelet Chemokines in Vascular Disease

(2008) Christian A. Gleissner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Restoration of Plasma von Willebrand Factor Deficiency Is Sufficient to Correct Thrombus Formation After Gene Therapy for Severe von Willebrand Disease

(2008) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protease-activated receptors as targets for antiplatelet therapy

(2008) Justin R. Hamilton   BLOOD REVIEWS

The protease-activated receptor-3 (PAR-3) can signal autonomously to induce interleukin-8 release

(2008) E. Ostrowska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fibrinolysis: The Key to New Pathogenetic Mechanisms

(2008) Esther Zorio et al.   CURRENT MEDICINAL CHEMISTRY

Primary and secondary capture of platelets onto inflamed femoral artery endothelium is dependent on P-selectin and PSGL-1

(2008) Oscar Ö. Braun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The FGF system has a key role in regulating vascular integrity

(2008) Masahiro Murakami et al.   JOURNAL OF CLINICAL INVESTIGATION

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1–dependent leukocyte recruitment in vivo

(2008) Daxin Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice

(2008) Aya Takaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration

(2008) Milan Popovic et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity

(2008) Samuel Chackalamannil et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thrombin-Stimulated Proliferation of Cultured Human Synovial Fibroblasts Through Proteolytic Activation of Proteinase-Activated Receptor-1

(2008) Ikue Furuhashi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Basic and Translational Research on Proteinase-Activated Receptors: Antagonism of the Proteinase-Activated Receptor 1 for Thrombin, a Novel Approach to Antiplatelet Therapy for Atherothrombotic Disease

(2008) Madhu Chintala et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Role of the Endothelium in the Vascular Effects of the Thrombin Receptor (Protease-Activated Receptor Type 1) in Humans

(2008) Ingibjörg J. Guðmundsdóttir et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Transcriptional Inhibition of Protease-Activated Receptor-1 Expression by Prostacyclin in Human Vascular Smooth Muscle Cells

(2007) Robert Pape et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase β in human endothelial cells

(2007) E Ritchie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2 −/− Mice

(2007) Noah Saederup et al.   CIRCULATION

Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system

(2007) Alvin H. Schmaier   INTERNATIONAL IMMUNOPHARMACOLOGY