Article
Endocrinology & Metabolism
M. E. Baldassarre, A. Di Mauro, F. Cresi, S. Salvatore, S. Aragona, G. Ciprandi
Summary: Cow's milk allergy is common in infancy, but there is no simple diagnostic tool. This study found that a two-month supplementation of the probiotic strain BB-12 significantly reduced symptom severity in artificially fed infants.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Allergy
Antti E. Seppo, Kevin Bu, Madina Jumabaeva, Juilee Thakar, Rakin A. Choudhury, Chloe Yonemitsu, Lars Bode, Camille A. Martina, Maria Allen, Sabrina Tamburini, Enrica Piras, David S. Wallach, R. John Looney, Jose C. Clemente, Kirsi M. Jarvinen
Summary: The study found a higher colonization rate of B. infantis in rural OOM infants at low risk for atopic diseases, similar to rates seen in developing countries. These infants' stool samples had higher levels of lactate and medium- to long/odd-chain fatty acids.
Article
Chemistry, Applied
Katarzyna Pacyga-Prus, Dominika Jakubczyk, Corine Sandstrom, Dagmar Srutkova, Marcelina Joanna Pyclik, Katarzyna Leszczynska, Jaroskaw Ciekot, Agnieszka Razim, Martin Schwarzer, Sabina Gorska
Summary: Bifidobacteria are commonly used probiotics with well-described effects on the immune system. Recently, there is growing interest in biologically active molecules derived from bacteria. We characterized surface antigens of Bifidobacterium adolescentis CCDM 368 and found that Bad368.1 polysaccharide modulates cytokine production, can be transferred between cells, and may have potential in allergic disease modulation.
CARBOHYDRATE POLYMERS
(2023)
Article
Microbiology
Shahriar Sepahvand, Mohammad Darvishi, Maral Mokhtari, Mohammad A. Davarpanah
Summary: In order to control the spread of Acinetobacter baumannii in hospitals, it is crucial to determine the source and transmission of the bacteria. This study used BOX-PCR and enterobacterial repetitive intergenic consensus PCR techniques to analyze samples. The results showed that 13% of the isolates were resistant to colistin, while 87% were sensitive. The strains were divided into different groups using the two PCR methods. Rapid identification and the use of appropriate tools are essential in preventing the further spread of colistin-resistant A. baumannii.
FUTURE MICROBIOLOGY
(2022)
Article
Immunology
Marcelina Joanna Pyclik, Dagmar Srutkova, Agnieszka Razim, Petra Hermanova, Tereza Svabova, Katarzyna Pacyga, Martin Schwarzer, Sabina Gorska
Summary: The study demonstrated that untreated Bifidobacterium strains have allergy-reducing properties, significantly suppressing airway inflammation and decreasing Th2-related cytokines and eosinophils. In contrast, heat-treated Bifidobacterium strains only reduced some inflammation markers while increasing other inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Sahar Sharif, Sam J. Oddie, Paul T. Heath, William McGuire
Summary: This review aims to evaluate the effectiveness of enteral supplementation with prebiotic oligosaccharides on the risk of necrotising enterocolitis, and associated morbidity and mortality, in very preterm or very low birth weight infants.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Microbiology
Hao Chung The, Chau Nguyen Ngoc Minh, Chau Tran Thi Hong, To Nguyen Thi Nguyen, Lindsay J. Pike, Caroline Zellmer, Trung Pham Duc, Tuan-Anh Tran, Tuyen Ha Thanh, Minh Pham Van, Guy E. Thwaites, Maia A. Rabaa, Lindsay J. Hall, Stephen Baker
Summary: Our study assessed the genomic diversity and metabolic profiles of B. pseudocatenulatum in the gut of healthy Vietnamese individuals. The B. pseudocatenulatum populations were distinct and diverse, with variation attributed to carbohydrate-utilizing enzymes. Antimicrobial susceptibility profiling revealed beta-lactam susceptibility but variable resistance to other antibiotics, with genetic factors conferring resistance against certain antibiotics. Our findings provide insight into the potential for rational design of probiotics using B. pseudocatenulatum strains from the Vietnamese population.
MICROBIOLOGY SPECTRUM
(2021)
Article
Cell Biology
Michael J. Barratt, Sharika Nuzhat, Kazi Ahsan, Steven A. Frese, Aleksandr A. Arzamasov, Shafiqul Alam Sarker, M. Munirul Islam, Parag Palit, Md Ridwan Islam, Matthew C. Hibberd, Swetha Nakshatri, Carrie A. Cowardin, Janaki L. Guruge, Alexandra E. Byrne, Siddarth Venkatesh, Vinaik Sundaresan, Bethany Henrick, Rebbeca M. Duar, Ryan D. Mitchell, Giorgio Casaburi, Johann Prambs, Robin Flannery, Mustafa Mahfuz, Dmitry A. Rodionov, Andrei L. Osterman, David Kyle, Tahmeed Ahmed, Jeffrey Gordon
Summary: Disrupted development of the gut microbiota is a contributing cause of childhood malnutrition. An experiment found that giving B. infantis combined with LNT can increase the abundance of B. infantis subspecies in infants with severe acute malnutrition and promote weight gain, but the effect is still much lower than in healthy controls. A B. infantis strain, Bg_2D9, with superior fitness may have potential in treating malnourished infants.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Jiacui Shang, Shuo Yang, Xiangchen Meng
Summary: The composition of the microbiome in the early stages of life plays a crucial role in the health of developing infants, and human milk oligosaccharides (HMO) are important regulators in maintaining a healthy gut microbiota. This study analyzed the gut microbiota of 1-month-old breastfed infants in Jining and Harbin, China, as well as the HMO profiles in maternal breast milk. The results showed significant differences in the abundance of certain HMO between the two groups, and Bifidobacterium was found to be the predominant microbial species in both groups. Correlation analyses suggested that HMO are beneficial for the development of the gut microbiota in young infants, and the abundance of Bifidobacterium indicates their ability to efficiently utilize HMO for maintaining gut microflora homeostasis. Breast milk-derived HMO were found to be critical for shaping the gut microbiota in breastfed infants.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Microbiology
Qiong Jia, Xue Yu, Yanmei Chang, Yanxia You, Zekun Chen, Ying Wang, Bin Liu, Lijun Chen, Defu Ma, Yan Xing, Xiaomei Tong
Summary: Gut microbiota in preterm infants varies depending on gestational age. Alpha diversity of meconium decreases with increasing gestational age. Moderate to late preterm infants have the highest alpha diversity after 1 year. Opportunistic pathogens and probiotics show different colonization patterns in different gestational age groups.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Weiwei Cui, Qize Wen, Dengzhu Lurong, Yonghua Wu, Shenshen Gao, Jun Li, Na Li, Chundi Xu
Summary: Food allergy is a global health issue, affecting a considerable number of children and adults. This study investigates the therapeutic potential of probiotics Bifidobacterium longum CECT7894 on anaphylaxis in a mouse model of ovalbumin-induced food allergy. The findings suggest that B. longum CECT7894 can alleviate allergic symptoms and reduce IgE levels. Transcriptomic and metabolomic analysis reveal alterations in genes and metabolites related to sphingolipid metabolism, indicating that B. longum CECT7894 might suppress food allergy by regulating this pathway.
Article
Genetics & Heredity
Wenwei Lu, Zhangming Pei, Mengning Zang, Yuan-kun Lee, Jianxin Zhao, Wei Chen, Hongchao Wang, Hao Zhang
Summary: The research found that Bifidobacterium bifidum has an open pan-genome and a conserved core genome, with genetic diversity mainly reflected in carbohydrate metabolism and immune/competition-related factors. In addition, a novel CRISPR-Cas system was discovered in B. bifidum through this study.
Review
Nutrition & Dietetics
Minghui Sun, Jing Luo, Hanmei Liu, Yue Xi, Qian Lin
Summary: The mixed strain of Lactobacillus and Bifidobacterium can effectively prevent eczema in infants under three years old, regardless of family history. Factors such as probiotic dosage and timing of intervention also play a role in the preventive effects.
Article
Public, Environmental & Occupational Health
Rihab Lagha, Fethi Ben Abdallah, Asmaa A. H. ALKhammash, Nabil Amor, Mohamed M. Hassan, Imed Mabrouk, Majid Alhomrani, Ahmed Gaber
Summary: 30 clinical isolates of Klebsiella pneumoniae exhibited heterogeneity in antibiotic resistance profiles and high genetic diversity, with most being multidrug-resistant. Genetic variability, as shown by PCR genotyping of porins and efflux pumps, is an important factor to consider in controlling outbreaks of K. pneumoniae. (GTG)5-genotyping showed a significant correlation with antibiotic resistance patterns, suggesting its potential use in predicting antibiotic resistance profiles of K. pneumoniae.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Review
Immunology
Tetsuro Kobayashi, Kazuyo Moro
Summary: This review discusses the phenotypical and functional heterogeneity of skin ILCs reported in recent years, highlighting their roles in tissue-specificity and disease pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
R. Cohen, L. H. Preta, V. Joste, E. Curis, O. Huillard, A. Jouinot, C. Narjoz, A. Thomas-Schoemann, A. Bellesoeur, M. Tiako Meyo, J. Quilichini, D. Desaulle, I. Nicolis, A. Cessot, M. Vidal, F. Goldwasser, J. Alexandre, B. Blanchet
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Letter
Rheumatology
Anne-Priscille Trouvin, Emmanuel Curis, Ioannis Nicolis, Cyrielle Beller, Serge Perrot
Article
Rheumatology
Anne-Priscille Trouvin, Chouki Chenaf, Marie Riquelme, Emmanuel Curis, Ioannis Nicolis, Rose-Marie Javier, Pascale Vergne-Salle, Francoise Laroche, Sophie Pouplin, Nicolas Authier, Serge Perrot
Summary: The study examined opioid prescribing patterns by rheumatologists in France in 2015. Rheumatologists mainly prescribed morphine, less oxycodone and fentanyl, and generally followed national recommendations for short-term, low-dose opioid prescriptions for non-cancer pain.
Article
Gastroenterology & Hepatology
Julie Reygner, Christine Charrueau, Johanne Delannoy, Camille Mayeur, Veronique Robert, Celine Cuinat, Thierry Meylheuc, Aurelie Mauras, Jeremy Augustin, Ioannis Nicolis, Morgane Modoux, Francisca Joly, Anne-Judith Waligora-Dupriet, Muriel Thomas, Nathalie Kapel
Article
Hematology
Mathilde Payen, Ioannis Nicolis, Marie Robin, David Michonneau, Johanne Delannoye, Camille Mayeur, Nathalie Kapel, Beatrice Bercot, Marie-Jose Butel, Jerome Le Goff, Gerard Socie, Clotilde Rousseau
Article
Biotechnology & Applied Microbiology
Nathalie Esber, Aurelie Mauras, Johanne Delannoy, Chantal Labellie, Camille Mayeur, Marie-Aurore Caillaud, Toma Kashima, Landry Souchaud, Ioannis Nicolis, Nathalie Kapel, Anne-Judith Waligora-Dupriet
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Cell Biology
Bernardo Cuffaro, Aka L. W. Assohoun, Denise Boutillier, Lenka Sukenikova, Jeremy Desramaut, Samira Boudebbouze, Sophie Salome-Desnoulez, Jiri Hrdy, Anne-Judith Waligora-Dupriet, Emmanuelle Maguin, Corinne Grangette
Article
Microbiology
Bernardo Cuffaro, Aka L. W. Assohoun, Denise Boutillier, Veronique Peucelle, Jeremy Desramaut, Samira Boudebbouze, Mikael Croyal, Anne-Judith Waligora-Dupriet, Moez Rhimi, Corinne Grangette, Emmanuelle Maguin
Summary: This study evaluated the functional capacities of 21 strains isolated from the gut microbiota of neonates and adults, identifying fifteen strains with beneficial activities for potential management of chronic diseases, particularly obesity and inflammatory bowel diseases.
Article
Pharmacology & Pharmacy
H. Sadou Yaye, E. Caudron, I Sermet-Gaudelus, I Nicolis, P. Prognon, D. Pradeau
Summary: This study aims to develop new formulas with improved physicochemical and microbiological stability for measuring nasal transepithelial potential difference (NPD). By using CHESS software for modeling and experimental validation, new formulas with excellent stability were identified. These new formulas can be used for harmonizing and comparing NPD measurements in different specialized centers.
ANNALES PHARMACEUTIQUES FRANCAISES
(2022)
Article
Endocrinology & Metabolism
Fideline Bonnet-Serrano, Maxime Barat, Anna Vaczlavik, Anne Jouinot, Lucas Bouys, Christelle Laguillier-Morizot, Corinne Zientek, Catherine Simonneau, Etienne Larger, Laurence Guignat, Lionel Groussin, Guillaume Assie, Jean Guibourdenche, Ioannis Nicolis, Marie-Claude Menet, Jerome Bertherat
Summary: In adrenocortical benign tumors, the activity of distal steroidogenesis enzymes, including CYP1161, CYP11B2, and CYP17A1 on glucocorticoids, mineralocorticoids, and androgens pathways respectively, is decreased. This decrease is more pronounced in bilateral tumors and seems to be more related to the nature of the tumor rather than the increase in adrenal volume. The decreased enzymatic activity leads to an explosive response to ACTH, limiting the synthesis of bioactive steroids despite the increase in adrenal mass.
ENDOCRINE CONNECTIONS
(2022)
Article
Biochemistry & Molecular Biology
Martin Souce, Ali Tfayli, Veronique Rosilio, Ioannis Nicolis, Athena Kasselouri
Summary: In this study, the incorporation of two photosensitizing drugs, Temoporfin and Verteporfin, into a model membrane was investigated. The results showed that Temoporfin significantly affected the stretching vibrations of the membrane, while Verteporfin had a smaller impact and mainly remained at the polar interface of the membrane.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Immunology
Emilie Boucher, Caroline Plazy, Mathias L. Richard, Antonia Suau, Irene Mangin, Muriel Cornet, Delphine Aldebert, Bertrand Toussaint, Dalil Hannani
Summary: The gut microbiota plays a crucial role in the host's immune response to cancer, and dietary intervention can improve anti-cancer immunity. In this study, an inulin-enriched diet was found to enhance the anti-tumor response of CD4(+) and CD8(+) αβ T cells and reduce tumor growth in mouse models. The anti-tumor effect of inulin was dependent on the activation of intestinal and tumor-infiltrating (δ) T cells, highlighting their importance in anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Gael Toubon, Marie-Jose Butel, Jean-Christophe Roze, Ioannis Nicolis, Johanne Delannoy, Cecile Zaros, Pierre-Yves Ancel, Julio Aires, Marie-Aline Charles
Summary: Early life gut microbiota-influencing factors are crucial for long-term health, and this study aimed to investigate the associations between 20 early life factors and gut microbiota composition at 3.5 years old. The results showed that gestational age, mode of delivery, and breastfeeding were significantly associated with gut microbiota differences. Having a sibling and attending daycare center were also linked to specific enterotypes. Maternal factors such as country of birth and preconception body mass index influenced the microbiota characteristics of the children.
