Breaking Barriers. New Insights into Airway Epithelial Barrier Function in Health and Disease

Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury

(2013) Rachel L. Zemans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Radical-Containing Ultrafine Particulate Matter Initiates Epithelial-to-Mesenchymal Transitions in Airway Epithelial Cells

(2013) Paul T. Thevenot et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Caveolin-1 Controls Airway Epithelial Barrier Function. Implications for Asthma

(2013) Tillie-Louise Hackett et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1

(2013) L. S. Rodgers et al.   JOURNAL OF CELL SCIENCE

STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines

(2013) M. J. Rosen et al.   JOURNAL OF IMMUNOLOGY

Sustained Protein Kinase D Activation Mediates Respiratory Syncytial Virus-Induced Airway Barrier Disruption

(2013) F. Rezaee et al.   JOURNAL OF VIROLOGY

Crumbs3 Is Essential for Proper Epithelial Development and Viability

(2013) E. L. Whiteman et al.   MOLECULAR AND CELLULAR BIOLOGY

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

(2013) Ana C. Monteiro et al.   MOLECULAR BIOLOGY OF THE CELL

Completion of the entire hepatitis C virus life cycle in genetically humanized mice

(2013) Marcus Dorner et al.   NATURE

Chronic IL9 and IL-13 Exposure Leads to an Altered Differentiation of Ciliated Cells in a Well-Differentiated Paediatric Bronchial Epithelial Cell Model

(2013) Jeremy C. Parker et al.   PLoS One

Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI

(2012) Sowmya P. Lakshmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Human Epidermal Growth Factor Receptor Signaling in Acute Lung Injury

(2012) James H. Finigan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Claudins and alveolar epithelial barrier function in the lung

(2012) James A. Frank   Annals of the New York Academy of Sciences

Claudin Heterogeneity and Control of Lung Tight Junctions

(2012) Michael Koval   Annual Review of Physiology

Scribble is required for normal epithelial cell–cell contacts and lumen morphogenesis in the mammalian lung

(2012) Laura L. Yates et al.   DEVELOPMENTAL BIOLOGY

Barrier responses of human bronchial epithelial cells to grass pollen exposure

(2012) Cornelia Blume et al.   EUROPEAN RESPIRATORY JOURNAL

Skin Barrier Disruption: A Requirement for Allergen Sensitization?

(2012) Anna De Benedetto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genome-wide association study indicates two novel resistance loci for severe malaria

(2012) Christian Timmann et al.   NATURE

Claudin-4 Deficiency Results in Urothelial Hyperplasia and Lethal Hydronephrosis

(2012) Harumi Fujita et al.   PLoS One

Influenza Infects Lung Microvascular Endothelium Leading to Microvascular Leak: Role of Apoptosis and Claudin-5

(2012) Susan M. Armstrong et al.   PLoS One

Dynamic migration of    intraepithelial lymphocytes requires occludin

(2012) K. L. Edelblum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The occludin and ZO-1 complex, defined by small angle X-ray scattering and NMR, has implications for modulating tight junction permeability

(2012) B. R. Tash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

(2011) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction

(2011) Nels Olson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function

(2011) Leslie A. Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis

(2011) Hiromitsu Ohta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Do Cell Junction Protein Mutations Cause an Airway Phenotype in Mice or Humans?

(2011) Eugene H. Chang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Innate Immunity in the Respiratory Epithelium

(2011) Dane Parker et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Intrinsic Phenotypic Differences of Asthmatic Epithelium and Its Inflammatory Responses to Respiratory Syncytial Virus and Air Pollution

(2011) Tillie-Louise Hackett et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

ZO Proteins and Redox-Dependent Processes

(2011) Lorenza González-Mariscal et al.   ANTIOXIDANTS & REDOX SIGNALING

Occludin Protein Family: Oxidative Stress and Reducing Conditions

(2011) Ingolf E. Blasig et al.   ANTIOXIDANTS & REDOX SIGNALING

Evidence of tricellulin expression by immune cells, particularly microglia

(2011) Cibelle Mariano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Paracellular Permeability of Bronchial Epithelium is Controlled by CFTR

(2011) Nelly Weiser et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Claudin as a Target for Drug Development

(2011) A. Takahashi et al.   CURRENT MEDICINAL CHEMISTRY

Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects

(2011) Hiroyuki Fujita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defective epithelial barrier function in asthma

(2011) Chang Xiao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Polyinosinic:polycytidylic acid induces protein kinase D–dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells

(2011) Fariba Rezaee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Protein Suggests a Supramodular Organization of the Membrane-associated Guanylate Kinase (MAGUK) Family Scaffold Protein Core

(2011) Lifeng Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

Rhinovirus-Induced Barrier Dysfunction in Polarized Airway Epithelial Cells Is Mediated by NADPH Oxidase 1

(2011) A. T. Comstock et al.   JOURNAL OF VIROLOGY

Occludin: One Protein, Many Forms

(2011) P. M. Cummins   MOLECULAR AND CELLULAR BIOLOGY

Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia

(2011) Alan S. Fanning et al.   MOLECULAR BIOLOGY OF THE CELL

Multiple Phenotypes in Adult Mice following Inactivation of the Coxsackievirus and Adenovirus Receptor (Car) Gene

(2011) Ahmad Pazirandeh et al.   PLoS One

Planar polarity

(2011) Laura L. Yates et al.   Organogenesis

Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation

(2010) Andrei I. Ivanov et al.   AMERICAN JOURNAL OF PATHOLOGY

Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells

(2010) Michael J. LaFemina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Septin-2 Mediates Airway Epithelial Barrier Function in Physiologic and Pathologic Conditions

(2010) Venkataramana K. Sidhaye et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine

(2010) Atsushi Tamura et al.   GASTROENTEROLOGY

Tight junction defects in patients with atopic dermatitis

(2010) Anna De Benedetto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Insights into Regulated Ligand Binding Sites from the Structure of ZO-1 Src Homology 3-Guanylate Kinase Module

(2010) Ming F. Lye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dual Role of Zonula Occludens (ZO) Proteins

(2010) H. Bauer et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

Occludin is required for cytokine-induced regulation of tight junction barriers

(2010) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice

(2010) Whitney G. Smalley-Freed et al.   JOURNAL OF CLINICAL INVESTIGATION

Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers

(2010) Pierre LeSimple et al.   JOURNAL OF PHYSIOLOGY-LONDON

Isoform-Specific Regulation and Localization of the Coxsackie and Adenovirus Receptor in Human Airway Epithelia

(2010) Katherine J. D. A. Excoffon et al.   PLoS One

MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function

(2010) D. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Claudin-2–deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules

(2010) Shigeaki Muto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductance

(2010) Juan C. CARABALLO et al.   RESPIROLOGY

The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial    T Cell Activation

(2010) D. A. Witherden et al.   SCIENCE

The Molecular Interaction of CAR and JAML Recruits the Central Cell Signal Transducer PI3K

(2010) P. Verdino et al.   SCIENCE

β-Catenin Is Not Necessary for Maintenance or Repair of the Bronchiolar Epithelium

(2009) Anna C. Zemke et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Azithromycin Maintains Airway Epithelial Integrity duringPseudomonas aeruginosaInfection

(2009) Skarphedinn Halldorsson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tight Junctions

(2009) Jörg-Dieter Schulzke et al.   Annals of the New York Academy of Sciences

Zonula Occludens-1 and -2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions

(2009) Alan S. Fanning et al.   Annals of the New York Academy of Sciences

Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro

(2009) Tsuyoshi Ohkuni et al.   Medical Molecular Morphology

Zona Occludens-2 Is Critical for Blood–Testis Barrier Integrity and Male Fertility

(2009) Jianliang Xu et al.   MOLECULAR BIOLOGY OF THE CELL

ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton

(2009) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

(2009) Alexander Ploss et al.   NATURE

Diesel exhaust particles modulate the tight junction protein occludin in lung cells in vitro

(2009) Andrea D Lehmann et al.   Particle and Fibre Toxicology

Junctional Music that the Nucleus Hears: Cell-Cell Contact Signaling and the Modulation of Gene Activity

(2009) P. D. McCrea et al.   Cold Spring Harbor Perspectives in Biology

LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells

(2008) Yael Grumbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Rhinovirus Disrupts the Barrier Function of Polarized Airway Epithelial Cells

(2008) Umadevi Sajjan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular components of the adherens junction

(2008) Carien M. Niessen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation

(2008) W.I. de Boer et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node

(2008) Friederike Pfeiffer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effects of Ambient Air Particulate Exposure on Blood–Gas Barrier Permeability and Lung Function

(2008) Elvira Vaclavik Bräuner et al.   INHALATION TOXICOLOGY

Phosphorylation of Tyr-398 and Tyr-402 in Occludin Prevents Its Interaction with ZO-1 and Destabilizes Its Assembly at the Tight Junctions

(2008) Bertha C. Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Epidermal Growth Factor Receptor (EGFR) by a Novel Metalloprotease Pathway

(2008) David A. Bergin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state

(2008) Le Shen et al.   JOURNAL OF CELL BIOLOGY

Claudin-1, −2, −3, −4, −5, and −7 in Usual Interstitial Pneumonia and Sarcoidosis

(2008) Riitta Kaarteenaho-Wiik et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Reovirus Preferentially Infects the Basolateral Surface and Is Released from the Apical Surface of Polarized Human Respiratory Epithelial Cells

(2008) Katherine J. D. A. Excoffon et al.   JOURNAL OF INFECTIOUS DISEASES

Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection

(2008) S. Liu et al.   JOURNAL OF VIROLOGY

Early Embryonic Lethality of Mice Lacking ZO-2, but Not ZO-3, Reveals Critical and Nonredundant Roles for Individual Zonula Occludens Proteins in Mammalian Development

(2008) J. Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells

(2008) Tatsuya Katsuno et al.   MOLECULAR BIOLOGY OF THE CELL

Zona Occludens-2 Inhibits Cyclin D1 Expression and Cell Proliferation and Exhibits Changes in Localization along the Cell Cycle

(2008) Rocio Tapia et al.   MOLECULAR BIOLOGY OF THE CELL

Shear stress regulates aquaporin-5 and airway epithelial barrier function

(2008) V. K. Sidhaye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-functionalized multi-walled carbon nanotubes alter the paracellular permeability of human airway epithelial cells

(2008) Bianca Maria Rotoli et al.   TOXICOLOGY LETTERS

Polarity complex proteins

(2007) Emeline Assémat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure and function of claudins

(2007) Gerd Krause et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Megaintestine in Claudin-15–Deficient Mice

(2007) Atsushi Tamura et al.   GASTROENTEROLOGY