Article
Immunology
Daichi Murakami, Masamitsu Kono, Denisa Nanushaj, Fumie Kaneko, Tonia Zangari, Yasuteru Muragaki, Jeffrey N. Weiser, Muneki Hotomi
Summary: This study revealed that cigarette smoke exposure significantly promotes pneumococcal transmission in an infant mouse model by enhancing bacterial shedding from the colonized host and increasing susceptibility to colonization in new hosts. Local inflammation and mucosal changes were identified as important underlying mechanisms for transmission promotion by smoke exposure, attributable to the constituents of cigarette smoke rather than smoke itself. These findings provide the first experimental evidence of the impact of environmental factors on pneumococcal transmission and pathogenesis mechanisms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Flavia Rayssa Braga Martins, Maycon Douglas de Oliveira, Jessica Amanda Marques Souza, Celso Martins Queiroz-Junior, Francisco Pereira Lobo, Mauro Martins Teixeira, Nathalia Luisa Malacco, Frederico Marianetti Soriani
Summary: This study aimed to investigate the inflammatory mechanisms involved in pneumococcal pneumonia associated with chronic ethanol exposure. The results showed that alcohol-fed mice produced higher levels of nitric oxide and CXCL1 during pneumonia, exhibited reduced leukocyte infiltration and less severe lung inflammation, but no changes in survival after infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Analytical
Tim Axelrod, Evgeni Eltzov, Merav Lerman, Dorin Harpaz, Robert S. Marks
Summary: This study demonstrates that cigarette filters can reduce the harmful effects of cigarette smoke, but they cannot completely eliminate the impact on the human body. Smoking also affects quorum sensing and increases the risk of pulmonary infections.
Article
Environmental Sciences
Lilan Wang, Yao Wang, Jianwen Chen, Xue-Min Yang, Xing-Tao Jiang, Peiqing Liu, Min Li
Summary: This study compared the effects of cigarette smoke condensate (CSC) to electronic cigarette smoke condensate (ECSC) on human lung epithelial cells (BEAS-2B) at equivalent nicotine levels. The results showed that compared to CSC, ECSC did not significantly impact cell effects and gene expression profile at equimolar nicotine concentrations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Physiology
Marta Schiliro, Elizabeth R. Vogel, Lucia Paolini, Christina M. Pabelick
Summary: The detrimental effects of tobacco exposure on children's health are well known, and the prevalence of secondhand or direct cigarette smoke exposure in the pediatric population has not significantly decreased over time. Additionally, the rapid increase in e-cigarette use among adolescents has raised public health concerns.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Microbiology
Tomoko Sumitomo, Masanobu Nakata, Satoshi Nagase, Yuki Takahara, Mariko Honda-Ogawa, Yasushi Mori, Yukako Akamatsu, Masaya Yamaguchi, Shigefumi Okamoto, Shigetada Kawabata
Summary: Influenza A virus infection increases susceptibility to secondary bacterial pneumonia, with GP96 on infected cell surfaces mediating interactions with Streptococcus pneumoniae, leading to increased bacterial adherence and translocation. Inhibition of GP96 enhances pneumococcal clearance and reduces lung pathology in infected mice, suggesting a potential therapeutic target for inhibiting bacterial colonization in an IAV-infected respiratory tract.
Article
Endocrinology & Metabolism
Seung Hoon Kim, Minah Park, Gyu Ri Kim, Hye Jin Joo, Sung-In Jang
Summary: Mixed use of electronic and conventional cigarettes and exposure to secondhand smoke increase the risk of prediabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Microbiology
Nicolas Garin, Christophe Marti, Aicha Skali Lami, Virginie Prendki
Summary: Atypical pathogens, including Legionella spp., Chlamydia pneumoniae and psittaci, Mycoplasma pneumoniae, and Coxiella burnetii, are a group of intracellular bacteria that can cause community-acquired pneumonia. The prevalence of these pathogens varies, but they should be considered in the empiric antibiotic treatment of severe pneumonia cases.
Article
Toxicology
Ashley E. Russell, Zhaohao Liao, Mercedes Tkach, Patrick M. Tarwater, Matias Ostrowski, Clotilde Thery, Kenneth W. Witwer
Summary: Cigarette smoking has negative effects on immune system functioning and inflammation. This study investigates the role of cigarette smoke extract (CSE) on dendritic cell-derived extracellular vesicles (EVs) and their ability to activate and differentiate T-cells. The findings suggest that CSE can influence T-cell phenotypes towards Th1 and Th17.
TOXICOLOGY LETTERS
(2022)
Article
Critical Care Medicine
Farzad Moazed, Carolyn Hendrickson, Alejandra Jauregui, Jeffrey Gotts, Amanda Conroy, Kevin Delucchi, Hanjing Zhuo, Mikhaela Arambulo, Kathryn Vessel, Serena Ke, Thomas Deiss, Amy Ni, Aleksandra Leligdowicz, Jason Abbott, Mitchell J. Cohen, Pratik Sinha, Antonio Gomez, Kirsten Kangelaris, Lucy Kornblith, Michael Matthay, Neal Benowitz, Kathleen Liu, Carolyn S. Calfee
Summary: Cigarette smoke exposure is associated with an increased risk of developing ARDS in both pulmonary and nonpulmonary sepsis patients. Among ARDS patients, those with exposure to cigarette smoke have lower systemic inflammation levels, and active smokers also have lower severity of illness compared to non-smokers, indicating that smoking contributes to biological heterogeneity in ARDS.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Xiao-Yue Chen, Yi-Ying Chen, Willie Lin, Chien-Han Chen, Yu-Chieh Wen, Ta-Chih Hsiao, Hsiu-Chu Chou, Kian Fan Chung, Hsiao-Chi Chuang
Summary: The study demonstrates that human umbilical cord-derived mesenchymal stem cells have potential in reducing inflammation and emphysema severity in cigarette smoke-induced emphysematous mice. The effects include decreasing inflammatory cells, regulating cytokine levels, and improving lung fibroblast cell viability.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Eleftheria Letsiou, Luiz Gustavo Teixeira Alves, Matthias Felten, Timothy J. Mitchell, Holger C. Mueller-Redetzky, Steven M. Dudek, Martin Witzenrath
Summary: This study explores the effects of pneumolysin (PLY) on neutrophils and platelets. It found that PLY induces the release of neutrophil extracellular traps (NETs), neutrophil extracellular vesicles (nEVs), and platelet extracellular vesicles (pl-EVs), and these interactions play a significant role in modulating platelet functions during pneumococcal infections.
Article
Physiology
Michal Mastalerz, Elisabeth Dick, Ashesh Chakraborty, Elisabeth Hennen, Andrea C. Schamberger, Andreas Schroppel, Michael Lindner, Rudolf Hatz, Jurgen Behr, Anne Hilgendorff, Otmar Schmid, Claudia A. Staab-Weijnitz
Summary: This study investigated the effects of different cigarette smoke extract (CSE) exposure protocols on human bronchial epithelial cells and compared them with whole cigarette smoke (wCS) exposure. The results showed that different exposure protocols had differing effects on gene expression, with chronic CSE exposure, acute submerged CSE exposure, and wCS exposure of differentiated phBECs resulting in significant upregulation of smoke-induced genes. These findings provide guidance for the design of in vitro cigarette smoke exposure models in lung research.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Joao Paulo Miguel, Andressa da Cunha Dias, Nathalia Rodrigues Bettini, Samuel Antonio Biajo Amancio de Sousa, Marilia Pereira Lima Durao, Lucas Vaz de Castro Oliveira, Fernanda Monedeiro, Leandra Naira Zambelli Ramalho, Luiz Guilherme S. Branco, Joao Paulo Jacob Sabino, Marina de Toledo Durand
Summary: Chronic exposure to cigarette smoke of 1 or 2 cigarettes/day can lead to systemic changes and autonomic cardiocirculatory dysfunction in rats, especially with exposure to 2 cigarettes/day.
Article
Medicine, General & Internal
Neus Altet, Irene Latorre, Maria Angeles Jimenez-Fuentes, Antoni Soriano-Arandes, Raquel Villar-Hernandez, Celia Mila, Pablo Rodriguez-Fernandez, Beatriz Muriel-Moreno, Patricia Comella-del-Barrio, Pere Godoy, Joan-Pau Millet, Maria Luiza de Souza-Galvao, Carlos A. Jimenez-Ruiz, Jose Dominguez
Summary: This study found that exposure to second-hand smoke (SHS) is associated with an increased risk of tuberculosis (TB) and latent TB infection (LTBI) in children. Furthermore, smoking also affects the accuracy of Interferon-Gamma Release Assays (IGRAs) and cytokine immune responses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Applied
Michela Terlizzi, Chiara Colarusso, Umberto Di Maio, Aldo Pinto, Rosalinda Sorrentino
Summary: The study showed that NAXX has strong and long-lasting bacteriostatic activity, which is related to its antioxidant properties. It is identified as an innovative medicinal plant-derived strategy for managing oxidative stress- and microbial-based diseases.
NATURAL PRODUCT RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jargalsaikhan Dagvadorj, Karolina Mikulska-Ruminska, Gantsetseg Tumurkhuu, Rojo A. Ratsimandresy, Jessica Carriere, Allen M. Andres, Stefanie Marek-Iannucci, Yang Song, Shuang Chen, Malcolm Lane, Andrea Dorfleutner, Roberta A. Gottlieb, Christian Stehlik, Suzanne Cassel, Fayyaz S. Sutterwala, Ivet Bahar, Timothy R. Crother, Moshe Arditi
Summary: The balance between NLRP3 inflammasome activation and mitophagy is crucial for cellular homeostasis, with IL-1 alpha playing a key role in regulating this balance. IL-1 alpha deficiency can lead to altered cellular functions and health by affecting mitochondrial damage and NLRP3 inflammasome activation. The interaction between IL-1 alpha and mitochondrial cardiolipin disrupts mitophagy and enhances NLRP3 inflammasome activation, highlighting the importance of this regulatory mechanism in cellular health.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
Rebecca A. Porritt, David Zemmour, Masanori Abe, Youngho Lee, Meena Narayanan, Thacyana T. Carvalho, Angela C. Gomez, Daisy Martinon, Chintda Santiskulvong, Michael C. Fishbein, Shuang Chen, Timothy R. Crother, Kenichi Shimada, Moshe Arditi, Magali Noval Rivas
Summary: This study reveals the cellular landscape of inflamed vascular tissues in a murine model of KD vasculitis, showing that monocytes, macrophages, and dendritic cells are main sources of IL-1 beta, while fibroblasts and vascular smooth muscle cells express high levels of IL-1 receptor.
CIRCULATION RESEARCH
(2021)
Article
Immunology
Hongxu Xian, Yuan Liu, Alexandra Rundberg Nilsson, Raphaella Gatchalian, Timothy R. Crother, Warren G. Tourtellotte, Yi Zhang, German R. Aleman-Muench, Gavin Lewis, Weixuan Chen, Sarah Kang, Melissa Luevanos, Dorit Trudler, Stuart A. Lipton, Pejman Soroosh, John Teijaro, Juan Carlos de la Torre, Moshe Arditi, Michael Karin, Elsa Sanchez-Lopez
Summary: The study found that metformin can attenuate COVID-19-induced ARDS by inhibiting NLRP3 inflammasome activation, IL-1 beta and IL-6 secretion, and by blocking ATP and mtDNA synthesis.
Article
Medicine, Research & Experimental
Stefanie Marek-Iannucci, Asli B. Ozdemir, Debbie Moreira, Angela C. Gomez, Malcolm Lane, Rebecca A. Porritt, Youngho Lee, Kenichi Shimada, Masanori Abe, Aleksandr Stotland, David Zemmour, Sarah Parker, Elsa Sanchez-Lopez, Jennifer Van Eyk, Roberta A. Gottlieb, Michael C. Fishbein, Michael Karin, Timothy R. Crother, Magali Noval Rivas, Moshe Arditi
Summary: Kawasaki disease is a leading cause of acquired heart disease in children, with impaired autophagy/mitophagy and ROS contributing to cardiovascular lesions. Enhancing autophagic flux can reduce lesions, while autophagy blockade increases inflammation, demonstrating the potential of targeting this pathway in treatment.
Article
Immunology
Chiara Colarusso, Michela Terlizzi, Anna Falanga, Georgious Stathopoulos, Luigi De Lucia, Phillip M. Hansbro, Aldo Pinto, Rosalinda Sorrentino
Summary: This study demonstrates that AIM2 is involved in lung carcinogenesis and is associated with an immunosuppressive microenvironment. Upregulation of AIM2 is correlated with an inflammasome profile in non-smoker and smoker LUAD patients, while the correlation is weaker in former smokers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Asli E. Atici, Timothy R. Crother, Magali Noval Rivas
Summary: Cardiovascular diseases are a leading cause of death worldwide, and optimal mitochondrial function is crucial for the cardiovascular system. Mitochondrial quality control ensures the clearance of dysfunctional mitochondria and preserves mitochondrial homeostasis, playing a role in cell survival and adaptation to environmental stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Meeting Abstract
Immunology
Prasant K. Jena, Daiko Wakita, Angela C. Gomez, Thacyana T. Carvalho, Meena Narayanan, Youngho Lee, Patrice D. Cani, Willem M. de Vos, Suzanne Devkota, David M. Underhill, Shuang Chen, Kenichi Shimada, Timothy R. Crother, Moshe Arditi, Magali Noval Rivas
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Rebecca A. Porritt, David Zemmour, Masanori Abe, Shuang Chen, Timothy R. Crother, Kenichi Shimada, Moshe Arditi, Magali Noval Rivas
JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Stefanie Marek-Iannucci, Angela Gomez, Debbie Moreira, Malcolm Lane, Rebecca Porritt, Youngho Lee, Kenichi Shimada, Timothy R. Crother, Magali Noval Rivas, Moshe Arditi
Meeting Abstract
Hematology
Shuang Chen, Janet Markman, Kenichi Shimada, Timothy R. Crother, Malcolm Lane, Magali Noval Rivas, Prediman K. Shah, Moshe Arditi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Meeting Abstract
Rheumatology
Gantsetseg Tumurkhuu, Shuang Chen, Erica Montano, Malcolm Lane, Michifumi Yamashita, Janet Markman, Luz Blanco, Mariana Kaplan, Kenichi Shimada, Timothy Crother, Mariko Ishimori, Daniel J. Wallace, Caroline Jefferies, Moshe Arditi
ARTHRITIS & RHEUMATOLOGY
(2020)
Meeting Abstract
Immunology
Stefanie Marek-Iannucci, Angela C. Gomez, Debbie Moreira, Malcolm Lane, Rebecca Porritt, Youngho Lee, Kenichi Shimada, Timothy R. Crother, Magali Noval Rivas, Moshe Arditi
JOURNAL OF IMMUNOLOGY
(2020)
Meeting Abstract
Immunology
Kenichi Shimada, Nobuyuki Nosaka, Daisy Martinon, Timothy R. Crother, Moshe Arditi
JOURNAL OF IMMUNOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Shuang Chen, Janet L. Markman, Kenichi Shimada, Timothy R. Crother, Malcolm Lane, Amanda Abolhesn, Prediman K. Shah, Moshe Arditi
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2020)