Article
Peripheral Vascular Disease
Jordyn M. Thomas, Yeong H. Ling, Brooke Huuskes, Maria Jelinic, Prerna Sharma, Narbada Saini, Dorota M. Ferens, Henry Diep, Shalini M. Krishnan, Barbara K. Kemp-Harper, Paul M. O'Connor, Eicke Latz, Thiruma V. Arumugam, Tomasz J. Guzik, Michael J. Hickey, Ashley Mansell, Christopher G. Sobey, Antony Vinh, Grant R. Drummond
Summary: IL-18 is elevated in hypertensive patients, and its production by tubular epithelial cells contributes to elevated blood pressure, renal inflammation, and fibrosis in a low-renin hypertension mouse model. This suggests IL-18 as a promising therapeutic target for hypertension and kidney disease.
Article
Biochemistry & Molecular Biology
Sam Detry, Julie Andries, Yehudi Bloch, Cem Gabay, Danielle M. Clancy, Savvas N. Savvides
Summary: In this study, the sequestration mechanism of human IL-18 mediated by IL-18BP was elucidated based on the crystal structure of the IL-18:IL-18BP complex. The detailed structural analysis revealed the interaction landscape and ultra-high affinity of IL-18BP towards IL-18. The study also discovered a novel tetramer assembly, which effectively restrains IL-18 activity. These findings provide insights for structuredriven therapeutic strategies and further functional interrogation of IL-18.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Kenta Fujimura, Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Yoshiko Mizushina, Chintogtokh Baatarjav, Takayoshi Matsumura, Kinya Otsu, Norihiko Takeda, Hiroaki Mizukami, Kazuomi Kario, Masafumi Takahashi
Summary: Sepsis is a life-threatening syndrome, and its associated mortality is increased when cardiac dysfunction and damage (septic cardiomyopathy [SCM]) occur. The NLRP3 inflammasome plays a critical role in the pathophysiology of SCM, with the activation of IL-1 beta and IL-18 contributing to the development of SCM.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Cell Biology
Junjun Luan, Jingqi Fu, Congcong Jiao, Xiangnan Hao, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Guangyu Zhou, Hongyu Li, Wei Yang, Peter S. T. Yuen, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Summary: This study investigated the role of interleukin-18 (IL-18) in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The results showed that IL-18 deficiency can attenuate renal tubular damage, necroptosis, cell transdifferentiation, and fibrosis, and this renoprotective effect may be mediated by reducing the switch from M1 to profibrotic M2 macrophages.
CELL DEATH & DISEASE
(2022)
Review
Pharmacology & Pharmacy
Jordyn M. Thomas, Brooke M. Huuskes, Christopher G. Sobey, Grant R. Drummond, Antony Vinh
Summary: Chronic kidney disease (CKD) is an inflammatory condition, and the inflammasome and pro-inflammatory cytokine IL-18 play important roles in its development. Regulating the signaling pathways of the inflammasome and IL-18 may serve as potential targets for CKD treatment.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Kaveh Abdi, Karen Laky, Mehrnoosh Abshari, Elizabeth M. Hill, Larry Lantz, Nevil J. Singh, Eric O. Long
Summary: It has been found that NK cells produce IFN-gamma before the production of IL-12 by DCs in the early stage of immune response. Toll-like Receptor 4 (TLR4) on DCs and soluble factors produced by LPS-activated DCs play important roles in IFN-gamma production by NK cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Matthew J. Camiolo, Xiuxia Zhou, Qi Wei, Humberto E. Trejo Bittar, Naftali Kaminski, Anuradha Ray, Sally E. Wenzel
Summary: Asthma is a common disease with highly variable natural history and patient morbidity. Previous studies have linked gene expression changes in severe asthma to specific clinical and physiological characteristics. Using bronchial epithelial cell gene expression data, a transcriptional signature was identified for participants with exacerbation-prone asthma and impaired lung function. This approach identified a set of 31 genes that classified patients accurately and highlighted IL-18 signaling in severe asthma pathogenesis.
Article
Immunology
Bennet Frost, Maria Schmidt, Benjamin Klein, Henry Loeffler-Wirth, Knuth Krohn, Timo Reidenbach, Hans Binder, Antonia Stubenvoll, Jan C. Simon, Anja Saalbach, Manfred Kunz
Summary: This study used single-cell transcriptomic analyses to identify immune cell and nonimmune cell populations involved in psoriasis. Different immune-activated cell types and abnormal expression of IL-14, IL-18, and IL-32 were found in psoriatic skin. These findings provide insights into the role of IL-14, IL-18, and IL-32 in psoriasis pathogenesis.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Microbiology
Toshihiko Suzuki, Kotchakorn Boonyaleka, Tokuju Okano, Tamako Iida, Mitsunori Yoshida, Hanako Fukano, Yoshihiko Hoshino, Yoichiro Iwakura, Anthony S. Ablordey, Hiroshi Ashida
Summary: Buruli ulcer is an emerging chronic infectious skin disease caused by Mycobacterium ulcerans. The exotoxin mycolactone produced by the bacterium inhibits the translocation of newly synthesized proteins and has been shown to suppress the secretion of IL-1 beta and TNF-alpha. However, mycolactone induces the secretion of IL-1 beta through inflammasome activation. IL-18, on the other hand, is exclusively induced by bacterial infection and controls the progression of Buruli ulcer by controlling accumulation of neutrophils in the infected skin lesions.
Article
Immunology
Attila Szabo, Kevin S. O'Connell, Thor Ueland, Mashhood A. Sheikh, Ingrid Agartz, Dimitrios Andreou, Pal Aukrust, Birgitte Boye, Erlend Boen, Ole Kristian Drange, Torbjorn Elvsashagen, John Abel Engh, Sigrun Hope, Margrethe Collier Hoegh, Inge Joa, Erik Johnsen, Rune Andreas Kroken, Trine Vik Lagerberg, Tove Lekva, Ulrik Fredrik Malt, Ingrid Melle, Gunnar Morken, Terje Naerland, Vidar Martin Steen, Kjetil Sorensen, Kirsten Wedervang-Resell, Melissa Auten Weibell, Lars T. Westlye, Nils Eiel Steen, Ole Andreassen, Srdjan Djurovic
Summary: Patients with severe mental illnesses often have dysregulated immune responses, and dyslipidemia linked to systemic inflammasome activation plays a crucial role, yet specific immune mechanisms remain unknown in these disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Cell Biology
Nourin Shakeeb, Prashanth Varkey, Aimy Hynse, Amita Ajit
Summary: This study investigates the expression of inflammatory genes in saliva of COVID-19 patients and compares it with blood samples. The results show that IL-6, TNF-alpha, and IL-10 can be detected in both saliva and blood, and their expression levels are similar. Therefore, saliva may be used as an alternative specimen for monitoring inflammation in COVID-19 patients.
Article
Biochemistry & Molecular Biology
Guangming Su, Wei Yang, Shengjiao Wang, Chunhui Geng, Xiuru Guan
Summary: Ferroptosis is associated with atherosclerosis, and activation of SIRT1 can inhibit ferroptosis and IL-1(3 and IL-18 levels in foam cells, providing a novel therapeutic target for AS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pediatrics
Jianrong Shi, Lin He, Huiwen Zheng, Wei Li, Shuangshuang Huang, Yunling Li, Ran Tao
Summary: This study investigated the association of IL-4 and IL-18 gene polymorphisms with the susceptibility and severity of atopic dermatitis (AD) in Chinese children. The results showed that IL-4 rs2243283 G allele, CG genotype, and CG+GG genotype were significantly decreased in AD patients, while IL-18 rs7106524 A allele, AA genotype, and AG+AA genotype were significantly increased in severe AD patients.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biology
Tania Lebratti, Ying Shiang Lim, Adjoa Cofie, Prabhakar Andhey, Xiaoping Jiang, Jason Scott, Maria Rita Fabbrizi, Ayse Naz Ozanturk, Christine Pham, Regina Clemens, Maxim Artyomov, Mary Dinauer, Haina Shin
Summary: The study reveals that sustained type I interferon signaling drives pathogenic neutrophil responses and identifies IL-18 as a novel component of disease during genital HSV-2 infection. Therapeutic interventions targeting IFN signaling and IL-18 may have potential in treating HSV-2 genital disease.
Article
Allergy
Aurora Holgado, Zhuangzhuang Liu, Aigerim Aidarova, Christina Mueller, Mira Haegman, Yasmine Driege, Marja Kreike, Charlotte L. Scott, Inna S. Afonina, Rudi Beyaert
Summary: IL-33 plays a crucial role in allergic diseases, and A20 is involved in regulating IL-33 signaling. In the absence of A20 in macrophages, IL-33-induced lung immune responses are altered, with reduced type 2 immune response and increased production of IFN-gamma. This study reveals a novel role for A20 in regulating IL-33-induced STAT1 signaling in macrophages.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Reproductive Biology
Yan Chen, Xiaoliang Li, Huijuan Liao, Xiaotong Leung, Jiabei He, Xiang Wang, Fuping Li, Huanxun Yue, Wenming Xu
BIOLOGY OF REPRODUCTION
(2019)
Article
Medicine, Research & Experimental
Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin He
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2019)
Article
Neurosciences
Juan Cheng, Haojuan Wu, Huawei Liu, Hua Li, Hua Zhu, Yongmei Zhou, Hongxia Li, Wenming Xu, Jiang Xie
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Developmental Biology
Xiang Fang, Ling-Long Huang, Jian Xu, Cai-Qi Ma, Zhi-Heng Chen, Zhan Zhang, Cai-Hua Liao, Shu-Xin Zheng, Peng Huang, Wen-Ming Xu, Na Li, Ling Sun
DEVELOPMENTAL BIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Jiabei He, Sixian Wu, Xiaoliang Li, Li Tang, Hanxiao Chen, Lang Qin, Jiang Xie, Tao Lu, Wenming Xu
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2020)
Article
Cell Biology
Li Tang, Ming Yang, Lang Qin, Xiaoliang Li, Guolin He, Xinghui Liu, WenMing Xu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Review
Pharmacology & Pharmacy
Daolai Zhang, Yanfei Wang, Hui Lin, Yujing Sun, Mingwei Wang, Yingli Jia, Xiao Yu, Hui Jiang, Wenming Xu, Jin-Peng Sun, Zhigang Xu
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Review
Oncology
Yaoyao Zhang, Rui Gao, Hanxiao Chen, Wenming Xu, Yihong Yang, Xun Zeng, Xiaochi Sun, Sirui Zhang, Xiao Hu, Lang Qin
EUROPEAN JOURNAL OF CANCER
(2020)
Review
Medicine, General & Internal
Wei Zhang, Jing Chen, Guoqian He, Wenming Xu, Guolin He
Article
Oncology
Guo-Qian He, Yan Chen, Hui-Juan Liao, Wen-Ming Xu, Wei Zhang, Guo-Lin He
MOLECULAR MEDICINE REPORTS
(2020)
Article
Multidisciplinary Sciences
Yike Yin, Shiyu Cao, Huancheng Fu, Xueying Fan, Jingfei Xiong, Qiuyue Huang, Yu Liu, Kun Xie, Tie-Gang Meng, Yuliang Liu, Dan Tang, Tingting Yang, Biao Dong, Shiqian Qi, Ling Nie, Huiyuan Zhan, Hongbo Hu, Wenming Xu, Fuping Li, Lunzhi Dai, Qing-Yuan Sun, Zhonghan Li
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biotechnology & Applied Microbiology
Yang Ye, Sushi Jiang, Chao Zhang, Yanxiang Cheng, Huan Zhong, Tao Du, Wenming Xu, Ricardo Azziz, Huidong Zhang, Xiaomiao Zhao
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Oncology
Yi Lai, Hanxiao Chen, Ze Du, Shu Zhou, Wenming Xu, Tao Li
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Obstetrics & Gynecology
Sushi Jiang, Fengyi He, Rui Gao, Chaogang Chen, Xiaozhu Zhong, Xiaojia Li, Shen Lin, Wenming Xu, Lang Qin, Xiaomiao Zhao
Summary: This study aimed to investigate the role of neutrophil and neutrophil-to-lymphocyte ratio (NLR) as predictive risk markers for recurrent pregnancy loss (RPL) through a retrospective case-control study and a meta-analysis. The findings suggest that high neutrophil and NLR levels could be potential risk factors for RPL, and further large-scale studies are needed to confirm these associations.
REPRODUCTIVE SCIENCES
(2021)
Article
Developmental Biology
Minzhi Jia, Xiaoliang Li, Chuan Jiang, Ke Wang, Tao Zuo, Guolin He, Lang Qin, Wenming Xu
REPRODUCTION FERTILITY AND DEVELOPMENT
(2020)
