A20 is a master switch of IL-33 signaling in macrophages and determines IL-33–induced lung immunity

Biologics for allergic and immunologic diseases

(2022) Hideaki Morita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The basic immunology of asthma

(2021) Hamida Hammad et al.   CELL

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

(2021) Maria Faas et al.   IMMUNITY

IL-33, an Alarmin of the IL-1 Family Involved in Allergic and Non Allergic Inflammation: Focus on the Mechanisms of Regulation of Its Activity

(2021) Corinne Cayrol   Cells

Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice

(2020) Heleen Vroman et al.   ALLERGY

Treatment options in type-2 low asthma

(2020) Timothy SC Hinks et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting IFN/STAT1 Pathway as a Promising Strategy to Overcome Radioresistance

(2020) Shuya Liu et al.   OncoTargets and Therapy

IL-33trap is a novel IL-33 neutralizing biologic that inhibits allergic airway inflammation

(2019) Aurora Holgado et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL33 attenuates ventricular remodeling after myocardial infarction through inducing alternatively activated macrophages ethical standards statement

(2019) Jing Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TNF-α–induced protein 3 is a key player in childhood asthma development and environment-mediated protection

(2019) Johanna Krusche et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity

(2019) Arne Martens et al.   Cold Spring Harbor Perspectives in Biology

Pulmonary IL‐33 orchestrates innate immune cells to mediate RSV‐evoked airway hyperreactivity and eosinophilia

(2019) Yi‐Hsiu Wu et al.   ALLERGY

Dichotomous function of IL-33 in health and disease: From biology to clinical implications

(2018) Harald Braun et al.   BIOCHEMICAL PHARMACOLOGY

The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity

(2018) Maude Liegeois et al.   CELLULAR IMMUNOLOGY

TNF-α–induced protein 3 levels in lung dendritic cells instruct T H 2 or T H 17 cell differentiation in eosinophilic or neutrophilic asthma

(2018) Heleen Vroman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Therapeutic Strategies for Targeting IL-33/ST2 Signalling for the Treatment of Inflammatory Diseases

(2018) Wei-Yu Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The E3 ligase VHL controls alveolar macrophage function via metabolic–epigenetic regulation

(2018) Wen Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages

(2017) Catherine Sabatel et al.   IMMUNITY

Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms

(2017) M Yamaguchi et al.   Mucosal Immunology

A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis

(2016) Katelijne De Wilde et al.   ANNALS OF THE RHEUMATIC DISEASES

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

Exogenous IL-33 Restores Dendritic Cell Activation and Maturation in Established Cancer

(2016) Donye Dominguez et al.   JOURNAL OF IMMUNOLOGY

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

(2016) Michelle M. Stein et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk

(2015) D. Kaur et al.   ALLERGY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

(2015) Claudia U Duerr et al.   NATURE IMMUNOLOGY

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

(2015) M. J. Schuijs et al.   SCIENCE

Blockade of IL-33/ST2 ameliorates airway inflammation in a murine model of allergic asthma

(2014) Hea Yon Lee et al.   EXPERIMENTAL LUNG RESEARCH

CREB, ATF, and AP-1 Transcription Factors Regulate IFN-  Secretion by Human T Cells in Response to Mycobacterial Antigen

(2014) B. Samten et al.   JOURNAL OF IMMUNOLOGY

A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo

(2014) Klaus Heger et al.   PLOS BIOLOGY

Induced sputum levels of IL-33 and soluble ST2 in young asthmatic children

(2013) Agnes Hamzaoui et al.   JOURNAL OF ASTHMA

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

(2013) Klaus Bønnelykke et al.   NATURE GENETICS

Adenovirus-mediated delivery of soluble ST2 attenuates ovalbumin-induced allergic asthma in mice

(2012) H. Yin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

(2012) Kelly Verhelst et al.   EMBO JOURNAL

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases

(2012) Xingnan Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization

(2012) Derek K. Chu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The composition and signaling of the IL-35 receptor are unconventional

(2012) Lauren W Collison et al.   NATURE IMMUNOLOGY

The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

(2011) Mirjam Kool et al.   IMMUNITY

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

(2011) Mourad Matmati et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

(2011) Carole Ober et al.   NATURE GENETICS

Increased IL-33 expression by epithelial cells in bronchial asthma

(2010) David Préfontaine et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY