The role of disturbed blood flow in the development of pulmonary arterial hypertension: lessons from preclinical animal models

A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects

(2012) Jose Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toward Systems Biology of Pulmonary Hypertension

(2012) Ferhaan Ahmad et al.   CIRCULATION

MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension

(2012) Victoria N. Parikh et al.   CIRCULATION

Sildenafil enhances systolic adaptation, but does not prevent diastolic dysfunction, in the pressure-loaded right ventricle

(2012) Marinus A.J. Borgdorff et al.   EUROPEAN JOURNAL OF HEART FAILURE

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Egr-1 Expression During Neointimal Development in Flow-Associated Pulmonary Hypertension

(2011) Michael G. Dickinson et al.   AMERICAN JOURNAL OF PATHOLOGY

The monocrotaline model of pulmonary hypertension in perspective

(2011) Jose G. Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mast Cell Inhibition Improves Pulmonary Vascular Remodeling in Pulmonary Hypertension

(2011) Beatrijs Bartelds et al.   CHEST

Randomized Clinical Trial of Aspirin and Simvastatin for Pulmonary Arterial Hypertension

(2011) Steven M. Kawut et al.   CIRCULATION

Prolonged overcirculation-induced pulmonary arterial hypertension as a cause of right ventricular failure

(2011) B. Rondelet et al.   EUROPEAN HEART JOURNAL

Differential responses of the right ventricle to abnormal loading conditions in mice: pressure vs. volume load

(2011) Beatrijs Bartelds et al.   EUROPEAN JOURNAL OF HEART FAILURE

Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

(2011) Tero-Pekka Alastalo et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension

(2010) Benoit Rondelet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Shear stress and the endothelial transport barrier

(2010) John M. Tarbell   CARDIOVASCULAR RESEARCH

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era

(2010) Marc Humbert et al.   CIRCULATION

Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension

(2010) M. Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Management of Pulmonary Arterial Hypertension in Children

(2010) M.T.R. Roofthooft et al.   Paediatric Respiratory Reviews

The Effects of Antiangiogenic Compound SU5416 in a Rat Model of Pulmonary Arterial Hypertension

(2010) Seiichiro Sakao et al.   RESPIRATION

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Gene expression profile in flow-associated pulmonary arterial hypertension with neointimal lesions

(2009) Mirjam E. van Albada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Reversible or Irreversible Remodeling in Pulmonary Arterial Hypertension

(2009) Seiichiro Sakao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Right Ventricle Under Pressure

(2009) Harm J. Bogaard et al.   CHEST

Guidelines for the diagnosis and treatment of pulmonary hypertension

(2009) et al.   EUROPEAN RESPIRATORY JOURNAL

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

(2009) Paul M. Hassoun et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updated Clinical Classification of Pulmonary Hypertension

(2009) Gérald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress

(2008) Peter E. Oishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone

(2008) Noriyuki Homma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Cancer Paradigm of Severe Pulmonary Arterial Hypertension

(2008) Pradeep R. Rai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary arterial hypertension in congenital cardiac disease – the need for refinement of the Evian-Venice classification

(2008) Mirjam E. van Albada et al.   CARDIOLOGY IN THE YOUNG

Genetic Ablation of the Bmpr2 Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension

(2008) Kwon-Ho Hong et al.   CIRCULATION

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

Molecular pathogenesis of pulmonary arterial hypertension

(2008) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension

(2008) Liliana Moreno-Vinasco et al.   PHYSIOLOGICAL GENOMICS

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology

(2008) Peter F Davies   Nature clinical practice. Cardiovascular medicine

Effects of erythropoietin on advanced pulmonary vascular remodelling

(2007) M. E. van Albada et al.   EUROPEAN RESPIRATORY JOURNAL