Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences

Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells

(2012) B. R. Desroches et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Bridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology

(2012) Annamaria Carusi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Computational approaches to understand cardiac electrophysiology and arrhythmias

(2012) Byron N. Roberts et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Myofibroblast-Myocyte Coupling Through Adherens Junctions Slows Cardiac Electrical Propagation

(2012) Susan Thompson et al.   BIOPHYSICAL JOURNAL

Critical Factors for Cardiac Reprogramming

(2012) Deepak Srivastava et al.   CIRCULATION RESEARCH

Importance of Myocyte-Nonmyocyte Interactions in Cardiac Development and Disease

(2012) Ying Tian et al.   CIRCULATION RESEARCH

Simultaneous Voltage and Calcium Mapping of Genetically Purified Human Induced Pluripotent Stem Cell–Derived Cardiac Myocyte Monolayers

(2012) Peter Lee et al.   CIRCULATION RESEARCH

An Image-Based Model of Atrial Muscular Architecture

(2012) Jichao Zhao et al.   Circulation-Arrhythmia and Electrophysiology

Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction

(2012) M. Touvron et al.   Disease Models & Mechanisms

Modulation of Spiral-Wave Dynamics and Spontaneous Activity in a Fibroblast/Myocyte Heterocellular Tissue–-A Computational Study

(2012) A. Greisas et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Computational modeling of the human atrial anatomy and electrophysiology

(2012) Olaf Dössel et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Matricellular Proteins in Cardiac Adaptation and Disease

(2012) Nikolaos G. Frangogiannis   PHYSIOLOGICAL REVIEWS

Electromechanical models of the ventricles

(2011) Natalia A. Trayanova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses

(2011) Peng Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Myofibroblasts cause heterogeneous Cx43 reduction and are unlikely to be coupled to myocytes in the healing canine infarct

(2011) Jennifer R. Baum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Three-Dimensional Modeling and Quantitative Analysis of Gap Junction Distributions in Cardiac Tissue

(2011) Daniel P. Lackey et al.   ANNALS OF BIOMEDICAL ENGINEERING

Long-distance electrical coupling via tunneling nanotubes

(2011) Xiang Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Susceptibility to Arrhythmia in the Infarcted Heart Depends on Myofibroblast Density

(2011) Kathleen S. McDowell et al.   BIOPHYSICAL JOURNAL

Myocyte-fibroblast electrical coupling: the basis of a stable relationship?

(2011) E. L. Ongstad et al.   CARDIOVASCULAR RESEARCH

Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential

(2011) Saïd F. Askar et al.   CARDIOVASCULAR RESEARCH

Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor

(2011) Ji Zhang et al.   CARDIOVASCULAR RESEARCH

Arrhythmogenic consequences of myofibroblast–myocyte coupling

(2011) Thao P. Nguyen et al.   CARDIOVASCULAR RESEARCH

Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes

(2011) Kangmin He et al.   CARDIOVASCULAR RESEARCH

Organotypic slice culture from human adult ventricular myocardium

(2011) Matthias Brandenburger et al.   CARDIOVASCULAR RESEARCH

Pannexin channels are not gap junction hemichannels

(2011) Gina E. Sosinsky et al.   Channels

Mechanical Coupling Between Myofibroblasts and Cardiomyocytes Slows Electric Conduction in Fibrotic Cell Monolayers

(2011) Susan A. Thompson et al.   CIRCULATION

Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism

(2011) Federica Accornero et al.   CIRCULATION RESEARCH

Whole-Heart Modeling

(2011) Natalia A. Trayanova   CIRCULATION RESEARCH

Neonatal Mouse–Derived Engineered Cardiac Tissue

(2011) W.J. de Lange et al.   CIRCULATION RESEARCH

Derivation of Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling

(2011) Kamileh Narsinh et al.   CIRCULATION RESEARCH

Fibroblast–myocyte connections in the heart

(2011) Peter Kohl et al.   HEART RHYTHM

Cardiac Fibroblasts in Cell Culture Systems: Myofibroblasts All Along?

(2011) Stephan Rohr   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The Cardiac Fibroblast: Functional and Electrophysiological Considerations in Healthy and Diseased Hearts

(2011) Carolina Vasquez et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Biomarkers of Myocardial Fibrosis

(2011) Sanne de Jong et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Communication Signals Between Cardiac Fibroblasts and Cardiac Myocytes

(2011) Filomena G Ottaviano et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Fibroblasts and Myofibroblasts: What Are We Talking About?

(2011) Jennifer Baum et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Adult mouse epicardium modulates myocardial injury by secreting paracrine factors

(2011) Bin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Adult human heart slices are a multicellular system suitable for electrophysiological and pharmacological studies

(2011) Patrizia Camelliti et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

S100B-RAGE dependent VEGF secretion by cardiac myocytes induces myofibroblast proliferation

(2011) James N. Tsoporis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function

(2011) Megan L. McCain et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Laser-guided cell micropatterning system

(2011) Russell K. Pirlo et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

The dynamics of fibroblast-myocyte-capillary interactions in the heart

(2010) Stephanie L.K. Bowers et al.   Annals of the New York Academy of Sciences

Engineering systems for the generation of patterned co-cultures for controlling cell–cell interactions

(2010) Hirokazu Kaji et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication

(2010) Yan Zhang et al.   CARDIOVASCULAR PATHOLOGY

Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation

(2010) L. Yue et al.   CARDIOVASCULAR RESEARCH

Tachycardia of atrial myocytes induces collagen expression in atrial fibroblasts through transforming growth factor  1

(2010) C.-T. Tsai et al.   CARDIOVASCULAR RESEARCH

Cell Communications in the Heart

(2010) Daniela Tirziu et al.   CIRCULATION

Intramyocardial Fibroblast Myocyte Communication

(2010) Rahul Kakkar et al.   CIRCULATION RESEARCH

Enhanced Fibroblast–Myocyte Interactions in Response to Cardiac Injury

(2010) Carolina Vasquez et al.   CIRCULATION RESEARCH

Fibrosis and Cardiac Arrhythmias

(2010) Sanne de Jong et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis

(2010) Pyoung Oh Yoon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels

(2010) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organotypic heart slices for cell transplantation and physiological studies

(2010) Walter Habeler et al.   Organogenesis

Cardiac alternans induced by fibroblast-myocyte coupling: mechanistic insights from computational models

(2009) Yuanfang Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Model of Electrical Conduction in Cardiac Tissue Including Fibroblasts

(2009) Frank B. Sachse et al.   ANNALS OF BIOMEDICAL ENGINEERING

A Method to Replicate the Microstructure of Heart Tissue In Vitro Using DTMRI-Based Cell Micropatterning

(2009) Nima Badie et al.   ANNALS OF BIOMEDICAL ENGINEERING

Pannexins, distant relatives of the connexin family with specific cellular functions?

(2009) Catheleyne D'hondt et al.   BIOESSAYS

Electrotonic Coupling between Human Atrial Myocytes and Fibroblasts Alters Myocyte Excitability and Repolarization

(2009) Mary M. Maleckar et al.   BIOPHYSICAL JOURNAL

Novel Micropatterned Cardiac Cell Cultures with Realistic Ventricular Microstructure

(2009) Nima Badie et al.   BIOPHYSICAL JOURNAL

Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes

(2009) Dawn M. Pedrotty et al.   CARDIOVASCULAR RESEARCH

Cardiac Fibroblast

(2009) Colby A. Souders et al.   CIRCULATION RESEARCH

Interleukin-33 Prevents Apoptosis and Improves Survival After Experimental Myocardial Infarction Through ST2 Signaling

(2009) Kenjiro Seki et al.   Circulation-Heart Failure

Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling

(2009) Masaki Ieda et al.   DEVELOPMENTAL CELL

Cx43 contributes to TGF-β signaling to regulate differentiation of cardiac fibroblasts into myofibroblasts

(2009) Yuko Asazuma-Nakamura et al.   EXPERIMENTAL CELL RESEARCH

Myofibroblasts in diseased hearts: New players in cardiac arrhythmias?

(2009) Stephan Rohr   HEART RHYTHM

Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study

(2009) Yuanfang Xie et al.   HEART RHYTHM

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

(2009) Norifumi Takeda et al.   JOURNAL OF CLINICAL INVESTIGATION

The extracellular matrix: At the center of it all

(2009) Stephanie L.K. Bowers et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac connexins and impulse propagation

(2009) John A. Jansen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Generation of histo-anatomically representative models of the individual heart: tools and application

(2009) G. Plank et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Characterization of Multiple Ion Channels in Cultured Human Cardiac Fibroblasts

(2009) Gui-Rong Li et al.   PLoS One

Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium

(2009) Mary M. Maleckar et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Challenges in Cardiac Tissue Engineering

(2009) Gordana Vunjak-Novakovic et al.   TISSUE ENGINEERING PART B-REVIEWS

Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay

(2008) Dawn M. Pedrotty et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model

(2008) Vincent Jacquemet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Basal and IGF-I-dependent regulation of potassium channels by MAP kinases and PI3-kinase during eccentric cardiac hypertrophy

(2008) Leyla Y. Teos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Electrotonic Myofibroblast-to-Myocyte Coupling Increases Propensity to Reentrant Arrhythmias in Two-Dimensional Cardiac Monolayers

(2008) Sharon Zlochiver et al.   BIOPHYSICAL JOURNAL

Connexin43 Expression Levels Influence Intercellular Coupling and Cell Proliferation of Native Murine Cardiac Fibroblasts

(2008) Yan Zhang et al.   CELL COMMUNICATION AND ADHESION

Differential Behaviors of Atrial Versus Ventricular Fibroblasts

(2008) Brett Burstein et al.   CIRCULATION

Myofibrillar Architecture in Engineered Cardiac Myocytes

(2008) Kevin Kit Parker et al.   CIRCULATION RESEARCH

Intercellular transfer mediated by tunneling nanotubes

(2008) Hans-Hermann Gerdes et al.   CURRENT OPINION IN CELL BIOLOGY

P2Y6 receptor-Gα12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis

(2008) Motohiro Nishida et al.   EMBO JOURNAL

Electrophysiological effects of angiotensin II. Part I: signal transduction and basic electrophysiological mechanisms

(2008) A. Goette et al.   EUROPACE

Diacylglycerol kinase ζ inhibits Gαq-induced atrial remodeling in transgenic mice

(2008) Masamichi Hirose et al.   HEART RHYTHM

Myofibroblast communication is controlled by intercellular mechanical coupling

(2008) L. Follonier et al.   JOURNAL OF CELL SCIENCE

Cell-to-cell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture

(2008) E. Y. Plotnikov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Membrane nanotubes: dynamic long-distance connections between animal cells

(2008) Daniel M. Davis et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY