Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ2

Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes

(2011) Hong Zhou et al.   ACTA PHARMACOLOGICA SINICA

PKCβ inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfuntion in rats with streptozotocin-induced diabetes

(2011) Yanan Liu et al.   CLINICAL SCIENCE

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein Kinase C II-Mediated Phosphorylation of Endothelial Nitric Oxide Synthase Threonine 495 Mediates the Endothelial Dysfunction Induced by FK506 (Tacrolimus)

(2011) V. L. Chiasson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Protein kinase C βII and δ/θ play critical roles in bone morphogenic protein-4-stimulated osteoblastic differentiation of MC3T3-E1 cells

(2010) Ki Ho Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases

(2010) Ming Dong et al.   DRUG DISCOVERY TODAY

Role of Calcium-independent Phospholipase A2β in High Glucose-induced Activation of RhoA, Rho Kinase, and CPI-17 in Cultured Vascular Smooth Muscle Cells and Vascular Smooth Muscle Hypercontractility in Diabetic Animals

(2010) Zhongwen Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart

(2010) Toru Okazaki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Oxidative Stress Stimulates Apoptosis and Activates NF-κB in Osteoblastic Cells via a PKCβ/p66shcSignaling Cascade: Counter Regulation by Estrogens or Androgens

(2010) Maria Almeida et al.   MOLECULAR ENDOCRINOLOGY

Inhibition of Protein Kinase C–β by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy

(2009) Kim A. Connelly et al.   Circulation-Heart Failure

Selective Inhibition of Protein Kinase C  2 Attenuates Inducible Nitric Oxide Synthase-Mediated Cardiovascular Abnormalities in Streptozotocin-Induced Diabetic Rats

(2009) P. R. Nagareddy et al.   DIABETES

Hypothesis: the “metabolic memory”, the new challenge of diabetes

(2009) Antonio Ceriello   DIABETES RESEARCH AND CLINICAL PRACTICE

Ruboxistaurin: PKC-β inhibition for complications of diabetes

(2009) Ronald P Danis et al.   EXPERT OPINION ON PHARMACOTHERAPY

Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCβ2/Rac1-dependent signaling

(2009) Li-Hua Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms

(2009) L Massip et al.   ONCOGENE

IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction

(2008) Jun Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats

(2008) Hesham Soliman et al.   CARDIOVASCULAR RESEARCH

High glucose increases phosphocofilin via phosphorylation of LIM kinase due to Rho/Rho kinase activation in cultured pig proximal tubular epithelial cells

(2008) Fukashi Ishibashi   DIABETES RESEARCH AND CLINICAL PRACTICE

Glucose-Dependent Enhancement of Diabetic Bladder Contraction Is Associated with a Rho Kinase-Regulated Protein Kinase C Pathway

(2008) K. Nobe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Upregulation of Endothelial and Inducible Nitric Oxide Synthase Expression by Reactive Oxygen Species

(2007) J. Zhen et al.   AMERICAN JOURNAL OF HYPERTENSION

High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase-mediated NF-κB activation in bovine aortic endothelial cells

(2007) Hitoshi Iwasaki et al.   ATHEROSCLEROSIS