Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Summary: Microglial cells have an important role in the brain's immune system. LOX-1 expression was confirmed in microglial cells in the neonatal hypoxic-ischemic encephalopathy model brain. LOX-1 activates cytokines and chemokines through intracellular pathways. This study investigated the role and molecular mechanism of LOX-1 gene transcription in microglial cells under hypoxic and ischemic conditions.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biology
Keiichiro Matoba, Yusuke Takeda, Yosuke Nagai, Kensuke Sekiguchi, Rikako Ukichi, Hiroshi Takahashi, Daisuke Aizawa, Masahiro Ikegami, Toshiaki Tachibana, Daiji Kawanami, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Summary: ROCK2 is activated in diabetic models and patients, but its deletion in podocytes provides protection against kidney injury by rescuing PPAR alpha signaling and fatty acid metabolism. Loss of podocytes is a common feature in diabetic renal injury, and ROCK2 plays a critical role in this process. The findings suggest that ROCK2 could be a potential target for the treatment of diabetic podocytopathy.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Huakang Zhou, Xuanchen Li, Majeed Rana, Jan Frederick Cornelius, Dilaware Khan, Sajjad Muhammad
Summary: Cardiovascular risk factors can induce cellular senescence, leading to vascular tissue inflammation and the development of cardiovascular diseases. Rapalink-1, an mTOR inhibitor, can block ethanol-induced senescence and reduce the expression of pro-inflammatory molecules and MMP-2.
Article
Medicine, Research & Experimental
Jiajun Chen, He Peng, Chaojie Chen, Ying Wang, Tingting Sang, Zheqi Cai, Qian Zhao, Shengjia Chen, Xiaojian Lin, Thomas Eling, Xingya Wang
Summary: NAG-1/GDF15 plays an important role in inhibiting the development and progression of diabetic nephropathy (DN) by targeting the AGE/RAGE-mediated inflammation pathways.
Article
Cell Biology
Anna Kowalczuk, Nabila Bourebaba, Katarzyna Kornicka-Garbowska, Eliza Turlej, Krzysztof Marycz, Lynda Bourebaba
Summary: The study demonstrates that calystegines from Hyoscyamus albus provide cytoprotection to HepG2 cells against insulin/glucose induced insulin resistance and apoptosis by regulating SIRT1/Foxo1/G6PC/mTOR and NF-kappaB/JNK/TLR4 signaling pathways.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Pharmacology & Pharmacy
Priscilla Natalia, Julia Zwirchmayr, Ieva Rudzionyte, Alexandra Pulsinger, Johannes M. Breuss, Pavel Uhrin, Judith M. Rollinger, Rainer de Martin
Summary: Based on scientific research and traditional use, this study investigated the anti-inflammatory potential of red sandalwood in IL-1 stimulated endothelial cells. The results showed that red sandalwood extract can suppress the induction of molecules that mediate leukocyte adhesion to the endothelium, while stimulating the activation of the JNK signaling pathway. Gene expression profiling revealed that red sandalwood extract selectively inhibits certain IL-1 induced genes and stimulates the expression of negative regulatory genes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Zixuan Lin, Chen Chen, Dongqin Yang, Jianqing Ding, Guanghui Wang, Haigang Ren
Summary: DJ-1 plays a crucial role in neuroinflammation by facilitating the interaction between IκBα and p65 in microglia, resulting in the repression of microglial activation and the protection of DA neurons from inflammation-induced injury in Parkinson's disease.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Marwa M. Abu-Serie, Noha H. Habashy
Summary: Relapse and drug resistance in leukemia can be overcome by targeting leukemia-initiating stem/progenitor cells (LICs). This study evaluated the anti-leukemic effect of royal jelly (RJ) components, particularly MRJP2, which showed higher growth inhibitory activity against leukemia cell lines and suppressed oncogenes associated with LICs. Furthermore, MRJP2 demonstrated greater apoptosis-inducing activity and inhibited metastasis markers and LIC survival. These findings suggest that MRJP2 can be a promising therapeutic agent for both myeloid and lymphoid leukemia.
Article
Environmental Sciences
Junyan Yan, Yaxin Tang, Xin Zhong, Huarong Huang, Haonan Wei, Yulei Jin, Yanjiang He, Jinqiao Cao, Lifang Jin, Baowei Hu
Summary: Exposure to carbon blacks (CBs) can activate the RhoA/ROCK pathway in mice lungs, leading to the progression of pulmonary fibrosis. However, treatment with ROCK inhibitor Y-27632 can attenuate this activation and inhibit the development of pulmonary fibrosis.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Kelly A. McCorkell, Nipun Jayachandran, Michelle D. Cully, Jacquelyn Freund-Brown, Tiffany Weinkopff, James Monslow, Yinling Hu, Ellen Pure, Bruce D. Freedman, Jorge Alvarez, Michael P. Cancro, Michael J. May
Summary: Global inactivation of IKK-alpha leads to defective lymph node formation and B cell maturation. IKK-alpha in distinct EC-derived compartments is uniquely required to promote B cell homeostasis and LN development, and LEC-intrinsic IKK-alpha is absolutely essential for LN formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Jia-Ni Yuan, Yu Hong, Zhuo-Lin Ma, Rui-Ping Pang, Qing-Qing Lei, Xiao-Fei Lv, Jia-Guo Zhou, Hui Huang, Ting-Ting Zhang
Summary: miR-302a acts as an effective suppressor of vascular inflammation by inhibiting the NF-kappa B pathway in endothelial cells, indicating its potential as a novel target for relieving vascular inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Yanting Xu, Ziyi Xu, Xiaobin Gu, Yue Xie, Ran He, Jing Xu, Bo Jing, Xuerong Peng, Guangyou Yang
Summary: In this study, two arginine kinases (AKs) in Sarcoptes scabiei were found to play important roles in the host immune response. These AKs promote cell proliferation and inhibit cell apoptosis by activating the NF-κB signaling pathway and increasing the expression of Bcl-2 and Bcl-xl. Additionally, they also alter the immune balance by affecting the secretion of specific cytokines, participating in the allergic inflammation caused by S. scabiei.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bo Jin, Jiong Wang, Yi Chen, Wei Zuo, Bo Hong, Jie Li, Fang Huang, Mengpei Zhang, Yi Wang
Summary: Hyperglycemia-induced chronic inflammation is a crucial risk factor for diabetic cardiomyopathy (DCM). Focal adhesion kinase (FAK) has been found to be involved in inflammatory signaling pathway activation in cardiovascular diseases. In this study, a selective FAK inhibitor, PND-1186 (PND), was used to evaluate the therapeutic potential of FAK targeting in DCM, and it was found that PND treatment could decrease inflammation and improve cardiac function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue, Lihong Fan
Summary: Amygdalin induces apoptosis of lung cancer cells through multiple mechanisms, including altered expression of apoptosis-related proteins, activation of NF kappa B-1 gene, and inhibition of NF kappa B signaling cascade. These findings reveal the potential of amygdalin as a therapeutic agent for lung cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)