Article
Endocrinology & Metabolism
Zhongli Chen, A. S. Elise van der Sman, Stefan Groeneweg, Linda Johanna de Rooij, W. Edward Visser, Robin P. Peeters, Marcel E. Meima
Summary: Using pharmacological inhibitors, this study identified that MCT10 and LATs play a major role in T3 uptake in BeWo cells. T4 uptake appears to be independent of known TH transporters, suggesting the presence of alternative transporter(s) that are currently unknown.
Article
Endocrinology & Metabolism
Zhongli Chen, Robin P. Peeters, Selmar Leeuwenburgh, Michelle Broekhuizen, Rugina I. Neuman, Emilie Hitzerd, Lunbo Tan, Rutchanna M. S. Jongejan, Yolanda B. de Rijke, Irwin K. M. Reiss, A. H. Jan Danser, W. Edward Visser, Marcel E. Meima
Summary: Fetal development relies heavily on thyroid hormone. The transfer of thyroid hormone from mother to fetus is essential for fetal hormone availability, particularly in the early stages of pregnancy. However, the mechanisms of TH transfer across the placenta are not well understood. This study investigated the transport processes of TH across human placentas using an ex vivo perfusion system.
Article
Environmental Sciences
Xuan Li, Tao Yu, Muxin Zhai, Yongyuan Wu, Baojing Zhao, Cancan Duan, Huiru Cheng, Han Li, Zhaolian Wei, Yuanyuan Yang, Zhen Yu
Summary: This study found that cadmium exposure reduces placental angiogenesis in preeclampsia by decreasing the expression of PLGF and VEGF and increasing the expression of sFlt1. Cadmium exposure also decreases the expression of thyroid hormone receptor alpha and Dio2. These results suggest that cadmium exposure impairs placental angiogenesis in preeclampsia by disturbing thyroid hormone receptor signaling.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Biochemistry & Molecular Biology
Charles Megier, Gregoire Dumery, Dominique Luton
Summary: Thyroid hormones and iodine are crucial for regulating various physiological functions, such as metabolic rate, protein synthesis, and fetal development. Imbalances in thyroid and iodine metabolism can have negative effects, especially during pregnancy. The placenta, as the interface between the mother and fetus, plays a vital role in regulating thyroid and iodine metabolism. This review provides an update on the current understanding of thyroid and iodine metabolism in both normal and pathological pregnancies, highlighting their importance for maternal and fetal health.
Article
Environmental Sciences
Xinwen Dong, Weidong Wu, Sanqiao Yao, Haibin Li, Zhichun Li, Li Zhang, Jing Jiang, Jie Xu, Fengquan Zhang
Summary: PM2.5 exposure induced pathological changes in the thyroid and liver of rats, decreased TH levels, and led to oxidative stress responses. Activation of the HPT axis and altered hepatic transthyretin levels appear to crucially contribute to PM2.5-induced thyroid dysfunction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud
Summary: Depression is common during pregnancy and many women are prescribed antidepressants. These drugs may disrupt serotonin homeostasis in the placenta or fetus, potentially leading to adverse effects of antidepressant use during pregnancy.
Article
Agriculture, Dairy & Animal Science
C. B. Steinhauser, K. Askelson, K. C. Hobbs, F. W. Bazer, M. C. Satterfield
Summary: Maternal nutrient restriction during pregnancy can affect fetal growth and thyroid hormone levels, leading to lower thyroid hormone concentrations in NR SGA fetuses. Changes in thyroid hormone-associated proteins in placentomes of ewes having SGA fetuses suggest adaptations to and potential effects of nutritional restrictions.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Harleen Kaur, Beverly S. Muhlhausler, Claire T. Roberts, Kathryn L. Gatford
Summary: The growth hormone (GH)-insulin-like growth factor (IGF) axis undergoes significant changes during pregnancy, with increased secretion of GH and IGFs leading to maternal metabolic adaptations, enhanced placental function, and fetal growth. Exogenous GH or IGF treatment in animal models of normal and compromised pregnancy also promotes similar effects, suggesting alternative approaches to enhance maternal GH abundance during pregnancy for better maternal and fetal outcomes.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Theresa Porst, Joerg Johannes, Hans Gluschke, Richard Koehler, Sebastian Mehl, Peter Kuehnen, Kostja Renko, Waldemar B. Minich, Susanna Wiegand, Lutz Schomburg
Summary: The study found that MCT8-aAb and MCT10-aAb are prevalent in thyroid disease and obesity, with the highest prevalence of MCT8-aAb in thyroid patients. Serum with positive MCT8-aAb can impact T4 uptake in cell culture.
Review
Obstetrics & Gynecology
Sreenithi Santhakumar, Eunice S. Edison
Summary: This review summarizes the mechanisms and regulatory factors involved in maternal-fetal iron transport and placental iron regulation. Animal and human studies are discussed, and the role of placental iron regulation in thalassemia and hemochromatosis pregnancies is reviewed.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Medical Laboratory Technology
K. Aaron Geno, Robert D. Nerenz
Summary: Thyroid hormones play important roles in regulating basal metabolic rate, reproductive function, and fetal development. Dysfunction of maternal thyroid has been associated with increased risks of complications during pregnancy. Assessing thyroid function during pregnancy is challenging due to physiological changes.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Article
Environmental Sciences
Liqin Hu, Hong Mei, Xiaonan Cai, Xijiang Hu, Zhengrong Duan, Jiuying Liu, Yafei Tan, Pan Yang, Han Xiao, Aifen Zhou
Summary: Thyroid hormones are crucial for fetal growth and neurodevelopment. The potential of paraben exposure to disrupt the endocrine system has caused concerns. However, the impact of maternal paraben exposure on newborn thyroid hormone levels is still largely unknown.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Endocrinology & Metabolism
Xi Yang, Chen Zhang, Catherine Williamson, Yindi Liu, Yulai Zhou, Chunxiao Liu, Lei Chen, Yong Zhang, Tim Korevaar, Weibin Wu, Jianxia Fan
Summary: The study showed that higher thyroid hormone levels during early or late pregnancy were associated with higher bile acid concentrations and a higher risk of gestational hypercholanemia. Hyperthyroidism during pregnancy could be a novel risk factor for hypercholanemia.
Article
Medicine, General & Internal
Yew Wen Yap, Emeka Onyekwelu, Uazman Alam
Summary: Pregnancy is accompanied by metabolic changes related to the thyroid gland, making it crucial to understand and manage thyroid disorders in pregnant patients. This review focuses on the physiology and management of hyperthyroidism, hypothyroidism, and thyroid nodules during pregnancy.
Article
Environmental Sciences
Emily S. Barrett, Matthew Corsetti, Drew Day, Sally W. Thurston, Christine T. Loftus, Catherine J. Karr, Kurunthachalam Kannan, Kaja Z. LeWinn, Alicia K. Smith, Roger Smith, Frances A. Tylavsky, Nicole R. Bush, Sheela Sathyanarayana
Summary: Phthalates may disrupt the endocrine pathways in pregnant women, impacting pregnancy outcomes and fetal development. This study found associations between phthalate mixtures and changes in plasma pCRH levels, with differing effects observed among women with gestational diabetes and gestational hypertension.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
James Lee, Mathieu Paul Rodero, Jatin Patel, Davide Moi, Roberta Mazzieri, Kiarash Khosrotehrani
Article
Dermatology
Jatin Patel, Betoul Baz, Ho Yi Wong, James S. Lee, Kiarash Khosrotehrani
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Cell Biology
Kelly A. Landers, Huika Li, Robin H. Mortimer, Donald S. A. McLeod, Michael C. d'Emden, Kerry Richard
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Article
Cell & Tissue Engineering
Abbas Shafiee, Jatin Patel, Dietmar W. Hutmacher, Nicholas M. Fisk, Kiarash Khosrotehrani
Article
Multidisciplinary Sciences
Prudence Donovan, Jatin Patel, James Dight, Ho Yi Wong, Seen-Ling Sim, Valentine Murigneux, Mathias Francois, Kiarash Khosrotehrani
NATURE COMMUNICATIONS
(2019)
Article
Cell & Tissue Engineering
Seen-Ling Sim, Josue Alexis, Edwige Roy, Abbas Shafiee, Kiarash Khosrotehrani, Jatin Patel
STEM CELLS TRANSLATIONAL MEDICINE
(2019)
Article
Cell Biology
Samuel W. Lukowski, Jatin Patel, Stacey B. Andersen, Seen-Ling Sim, Ho Yi Wong, Joshua Tay, Ingrid Winkler, Joseph E. Powell, Kiarash Khosrotehrani
Article
Biology
Jeroen Overman, Frank Fontaine, Jill Wylie-Sears, Mehdi Moustaqil, Lan Huang, Marie Meurer, Ivy Kim Chiang, Emmanuelle Lesieur, Jatin Patel, Johannes Zuegg, Eddy Pasquier, Emma Sierecki, Yann Gambin, Mohamed Hamdan, Kiarash Khosrotehrani, Gregor Andelfinger, Joyce Bischoff, Mathias Francois
Letter
Dermatology
Laurancia Vina Stefia, James Lee, Jatin Patel, Silmara Rodrigues de Sousa, Julien Legrand, Mathieu Rodero, Sriti Burman, Richard Linedale, Mark Morrison, Kiarash Khosrotehrani
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Jilai Zhao, Jatin Patel, Simranpreet Kaur, Seen-Ling Sim, Ho Yi Wong, Cassandra Styke, Isabella Hogan, Sam Kahler, Hamish Hamilton, Racheal Wadlow, James Dight, Ghazaleh Hashemi, Laura Sormani, Edwige Roy, Mervin C. Yoder, Mathias Francois, Kiarash Khosrotehrani
Summary: The regulation of endothelial to mesenchymal transition in endovascular progenitors involves the expression of Sox9 and Rbpj, with blocking Sox9 affecting the transition and scarring size in skin wounds, while changes in Rbpj have the opposite effect.
NATURE COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Kirat K. Chand, Jatin Patel, S. T. Bjorkman, Seen-Ling Sim, Stephanie M. Miller, Elliot Teo, Lara Jones, Jane Sun, Paul B. Colditz, Kiarash Khosrotehrani, Julie A. Wixey
Summary: The study found that a dose of combined MSC-ECFC on the first day of life for FGR newborn piglets improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation, and improved adverse neuronal and white matter changes in the FGR newborn piglet brain. These effects were not observed with MSCs alone, indicating that cECFC treatment may act as a neuroprotectant for the FGR brain.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Haolu Wang, Leslie J. Burke, Jatin Patel, Brian Wc Tse, Kim R. Bridle, Victoria C. Cogger, Xinxing Li, Xin Liu, Haotian Yang, Darrell H. G. Crawford, Michael S. Roberts, Wenchao Gao, Xiaowen Liang
Article
Biochemistry & Molecular Biology
Kelly A. Landers, Michael C. d'Emden, Kerry Richard
Article
Physiology
Jennifer E. Outhwaite, Jatin Patel, David G. Simmons
FRONTIERS IN PHYSIOLOGY
(2019)